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http://dx.doi.org/10.5352/JLS.2016.26.8.970

The Suppression of Inflammatory Cytokines Induced by Propionibacterium acnes Using Bacteriocin Isolated from Lactobacillus plantarum K-1 BR  

Jeong, Jin Woong (Research Institute for Biological Sciences, Biorhythm Co., LTD)
Jung, Yong Hyun (Research Institute for Biological Sciences, Biorhythm Co., LTD)
Lee, Jong Sung (Bio-Center, Chungbuk Technopark)
Yoon, Seung Won (Bio-Center, Chungbuk Technopark)
Lee, Seung Yeon (Bio-Center, Chungbuk Technopark)
Lee, Hong Chan (Department of Renewable Energy Resources, Jungwon University)
Yoon, Young Geol (Department of Biomedical Science, Jungwon University)
Publication Information
Journal of Life Science / v.26, no.8, 2016 , pp. 970-975 More about this Journal
Abstract
Acne vulgaris is a common chronic skin disorder that affects millions of people. The pathogenesis of acne has been known to be closely associated with the bacterium Propionibacterium acnes. Here we investigated the anti-acne activity of Lactobacillus plantarum K-1 BR by observing the expressions of proinflammatory cytokines, TNF-α, IFN-γ and IL-8, of human keratinocytes. When we applied heat-killed P. acnes to HaCaT cells, the inflammatory cytokines were induced by two- to four-fold compared to the normal control. When the bacteriocin, purified from L. plantarum K-1 BR, was pretreated to the HaCaT cells, the expression levels of TNF-α and IFN-γ stimulated by P. acnes significantly decreased to 25% and 30% of the induced levels, respectively. The IL-8 levels also significantly decreased with the concentration dependent manner of the bacteriocin. These results suggest that the bacteriocin from L. plantarum K-1 BR could reduce the expression levels of inflammatory cytokines and thus may relieve inflammations caused by acne.
Keywords
Anti-acne; bacteriocin; inflammatory cytokines; Lactobacillus plantarum K-1 BR; Propionibacterium acnes;
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