A Novel Single Nucleotide Polymorphism of the Leptin Receptor Gene Associated with Backfat Thickness in Duroc Pigs
![]() |
Lee, Kyung-Tai
(Animal Genomics and Bioinformatics Division, National Institute of Animal Science, Rural Development Administration)
Lee, Hae-Young (Animal Genomics and Bioinformatics Division, National Institute of Animal Science, Rural Development Administration) Choi, Bong-Hwan (Animal Genomics and Bioinformatics Division, National Institute of Animal Science, Rural Development Administration) Kim, Jong-Joo (School of Biotechnology, Yeungnam University) Kim, Tae-Hun (Animal Genomics and Bioinformatics Division, National Institute of Animal Science, Rural Development Administration) |
1 | Gerbens, F., de Koning, D. J., Harders, F. L., Meuwissen, T. H., Janss, L. L., Groenen, M. A., Veerkamp, J. H., Van Arendonk, J. A. and te Pas, M. F. 2000. The effect of adipocyte and heart fatty acid-binding protein genes on intramuscular fat and backfat content in Meishan crossbred pigs. J. Anim. Sci. 78, 552-559. DOI |
2 | de Koning, D. J., Rattink, A. P., Harlizius, B., van Arendonk, J. A., Brascamp, E. W. and Groenen, M. A. 2000. Genome-wide scan for body composition in pigs reveals important role of imprinting. Proc. Natl. Acad. Sci. USA 97, 7947-7950. DOI |
3 | Friedman, J. M. and Halaas J. L. 1998. Leptin and the regulation of body weight in mammals. Nature 395, 763-770. DOI |
4 | Friedman, J. M. 2002. The function of leptin in nutrition, weight, and physiology. Nutr. Rev. 60, 85-87. DOI |
5 | Arnyasi, M., Grindflek, E., Javor, A. and Lien, S. 2006. Investigation of two candidate genes for meat quality traits in a quantitative trait locus region on SSC6: the porcine short heterodimer partner and heart fatty acid binding protein genes. J. Anim. Breed. Genet. 123, 198-203. DOI |
6 | Mackowski, M., Szymoniak, K., Szydlowski, M., Kamyczek, M., Eckert, R., Rozycki, M. and Switonski, M. 2005. Missense mutations in exon 4 of the porcine LEPR gene encoding extracellular domain and their association with fatness traits. Anim. Genet. 36, 135-137. DOI |
7 | Malek, M., Dekkers, J. C., Lee, H. K., Baas, T. J., Prusa, K., Huff-Lonergan, E. and Rothschild, M. F. 2001. A molecular genome scan analysis to identify chromosomal regions influencing economic traits in the pig. II. Meat and muscle composition. Mamm. Genome 12, 637-645. DOI |
8 | Miller, S. G., De Vos, P., Guerre-Millo, M., Wong, K., Hermann, T., Staels, B., Briggs, M. R. and Auwerx, J. 1996. The adipocyte specific transcription factor C/ EBPalpha modulates human ob gene expression. Proc. Natl. Acad. Sci. USA 93, 5507-5511. DOI |
9 | Chen, C. C., Chang, T. and Su, H. Y. 2004. Characterization of porcine leptin receptor polymorphisms and their association with reproduction and production traits. Anim. Biotechnol. 15, 89-102. DOI |
10 | Gong, D. W., Bi, S., Pratley, R. E. and Weintraub, B. D. 1996. Genomic structure and promoter analysis of the human obese gene. J. Biol. Chem. 271, 3971-3974. DOI |
11 | Ovilo, C., Oliver, A., Noguera, J. L., Clop, A., Barragan, C., Varona, L., Rodriguez, C., Toro, M., Sanchez, A., Perez-Enciso, M. and Silio, L. 2002. Test for positional candidate genes for body composition on pig chromosome 6. Genet. Sel. Evol. 34, 465-479. DOI |
12 | Ovilo, C., Clop, A., Noguera, J. L., Oliver, M. A., Barragan, C., Rodriguez, C., Silio, L., Toro, M. A., Coll, A., Folch, J. M., Sanchez, A., Babot, D. and Varona, L. 2002. Quantitative trait locus mapping for meat quality traits in an Iberian xLandrace F2 pig population. J. Anim. Sci. 80, 2801-2808. DOI |
13 | Ovilo, C., Fernandez, A., Noguera, J. L., Barragan, C., Leton, R., Rodriguez, C., Mercade, A., Alves, E., Folch, J. M., Varona, L. and Toro, M. 2005. Fine mapping of porcine chromosome6 QTL and LEPR effects on body composition in multiple generations of an Iberian by Landrace intercross. Genet. Res. 85, 57-67. DOI |
14 | Kim, J. J., Rothschild, M. F., Beever, J., Rodriguez-Zas, S. and Dekkers, J. C. M. 2005. Joint analysis of two breed cross populations in pigs to improve detection and characterization of quantitative trait loci. J. Anim. Sci. 83, 1229-1240. DOI |
15 | Grindflek, E., Szyda, J., Liu, Z. and Lien, S. 2001. Detection of quantitative trait loci for meat quality in a commercial slaughter pig cross. Mamm. Genome 12, 299-304. DOI |
16 | Jacob, M. and Gallinaro, H. 1989. The 5’ splice site: phylogenetic evolution and variable geometry of association with U1RNA. Nucleic Acids Res. 11, 2159-2180. |
17 | Jeon, J. T., Park, E. W., Jeon, H. J., Kim, T. H., Lee, K. T. and Cheong, I. C. 2003. A large-insert porcine library with seven fold genome coverage: a tool for positional cloning of candidate genes for major quantitative traits. Mol. Cells 16, 113-116. |
18 | Muñoz, G., Ovilo, C., Silió, L., Tomás, A., Noguera, J. L. and Rodríguez, M. C. 2009. Single- and joint-population analyses of two experimental pig crosses to confirm quantitative trait loci on Sus scrofa chromosome 6 and leptin receptor effects on fatness and growth traits. J. Anim. Sci. 87, 459-468. |
19 | Uemoto, Y., Kikuchi, T., Nakano, H., Sato, S., Shibata, T., Kadowaki, H., Katoh, K., Kobayashi, E. and Suzuki, K. 2012. Effects of porcine leptin receptor gene polymorphisms on backfat thickness, fat area ratios by image analysis, and serum leptin concentrations in a Duroc purebred population. Anim. Sci. J. 83, 375-385. DOI |
20 | Uleberg, E., Wideroe, I. S., Grindflek, E., Szyda, J., Lien, S. and Meuwissen, T. H. 2005. Fine mapping of a QTL for intramuscular fat on porcine chromosome 6 using combined linkage and linkage disequilibrium mapping. J. Anim. Breed Genet. 122, 1-6. |
21 | Sampath, H. and Ntambi, J. M. 2005. Polyunsaturated fatty acid regulation of genes of lipid metabolism. Annu. Rev. Nutr. 25, 317-340. DOI |
22 | Muñoz, G., Alcázar, E., Fernández, A., Barragán, C., Carrasco, A., de Pedro, E., Silió, L., Sánchez, J. L. and Rodríguez, M. C. 2010. Effects of porcine MC4R and LEPR polymorphisms, gender and Duroc sire line on economic traits in Duroc × Iberian crossbred pigs. Meat Sci. 88, 169-173. |
23 | Ovilo, C., Pérez-Enciso, M., Barragán, C., Clop, A., Rodríquez, C., Oliver, M. A., Toro, M. A. and Noruera, J. L. 2000. A QTL for intramuscular fat and backfat thickness is located on porcine chromosome 6. Mamm. Genome 11, 344-346. DOI |
24 | Qian, H., Hausman, G. J., Compton, M. M., Azain, M. J., Hartzell, D. L. and Baile, C. A. 1998. Leptin regulation of peroxisome proliferator-activated receptor-gamma, tumor necrosis factor, and uncoupling protein-2 expression in adipose tissues. Biochem. Biophys. Res. Commun. 246, 660-667. DOI |
25 | Tartaglia, L. A., Dembski, M., Weng, X., Deng, N., Culpepper, J., Devos, R., Richards, G. J., Campfield, L. A., Clark, F. T., Deeds, J., Muir, C., Sanker, S., Moriarty, A., Moore, K. J., Smutko, J. S., Mays, G. G., Wool, E. A., Monroe, C. A. and Tepper, R. I. 1995. Identification and expression cloning of a leptin receptor, OB-R. Cell 83, 1263-1271. DOI |
![]() |