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http://dx.doi.org/10.5352/JLS.2016.26.11.1225

Antimicrobial and Antioxidant Effects of Functional Healthy Drinks from Some Medicinal Herbs and Coffee Mixture  

Kim, In Hae (Department of Pharmaceutical Engineering, College of Medical & Life Science, Silla University)
Kim, JinKyun (The Gil Wondu Coffee)
Lee, Jae Hwa (Department of Pharmaceutical Engineering, College of Medical & Life Science, Silla University)
Publication Information
Journal of Life Science / v.26, no.11, 2016 , pp. 1225-1231 More about this Journal
Abstract
In this study, our investigated the antioxidant activities and compared other bioassay including anti-microbial, antifungal activities and total polyphenol contents of functional healthy drinks from some medicinal herbs and coffee mixture. The kind of medicinal herbs, chaga mushroom (Inonatus obliqurs), moringa (Moringa Oleifera), gravila (Anona muricata), mulberry (Morus alba), Dioscoreaceae (Dioscorea quinquelaba), Berberidaceae (Epimedii Herba), Asteraceae (Artemisia capillaries) and siberian ginseng (Acanthopanax senticous,). The functional healthy drinks, named C1, C2, C3, C4, C5, C6 and C7 were summered in Table 1. The in vitro antimicrobial activity was examined against Gram positive bacteria, Gram negative bacteria and a fungus. The functional healthy drinks were broad spectrum of anti-microbial activity without antifungal activity against Candida albicans KCTC7965. In particularly, the C7 showed strong activity against Methicillin Resistant Staphylococcus aureus CCARM3089, CCARM 3115 and CCARM3561. And, the C7 showed 88% of free radical scavenging effect on 0.5 mg/ml using 1,1-diphenyl-2-picrylhydrazyl (DPPH) method. Functional healthy drink C7 was mulberry extracts from Morus alba, chaga mushroom from Inonatus obliqurs and moringa from Moringa olifera in additionally coffee extracts. Its results confirm that the potential use of mulberry extracts as a good source of antibacterial compounds or as a health promoting food and health drinks.
Keywords
Antifungal activity; antimicrobial activity; functional healthy drinks; Methicillin Resistant Staphylococcus aureus; total polyphenol contents;
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1 Baek, G. H., Jeong H. S., Kim, H., Yoon, T. J., Suh, H. J. and Yu, K. W. 2012. Pharmacological activity of chaga mushroom on extraction conduction and immunostimulating polysaccharide. J. Kor. Soc. Food Sci. Nutr. 42, 1378-1384.
2 Shin, J. Y., Kim, H., Kim, D. G., Baek, G. H., Jeong, H. S. and Yu, K. W. 2013. Pharmacological activities of coffee roasted from fermented green coffee bean with fungal mycelia in solid-state culture. J. Kor. Soc. Food Sci. Nutr. 42, 487-496.   DOI
3 Shon, M. Y., Seo, J. K., Kim, H. J. and Sung, N. J. 2001. Chemical compositions and physiological activities of doraji (Platycodon grandiflorum). J. Kor. Soc. Food Sci. Nutr. 30, 717-720.
4 Blois, M. S. 1958. Antioxidant determination by the use of a stable free radical. Nature 181, 1199-1200.   DOI
5 Bohn, B., Nebe, C. T. and Birr, C. 1987. Flow-cytemeteric studies with Eleutheroacoccus senticosus extract as an immunomodulatory agent. Arzneimittel-Forschung 37, 1193-1197.
6 Cho, H. J. and Chang, Y. C. 2014. Extract of moringa root inhibits PMA-induced invasion of breast cancer cells. J. Life Sci. 24, 8-13.   DOI
7 Choi, W., Choi, J. Y. and Yon, H. S. 2013. A study on purchasing characteristics on health functional beverage according to food-related lifestyle. J. Hotel Resort 12, 179-196.
8 Taha, N. R., Amin, H. A. and Sultan, A. A. 2015. The protective effect on Moringa oleifera leaves against cyclophosphamide- induced urinary bladder toxicty in rats. Tissue Cell 47, 94-105.   DOI
9 Voya, J., Belinky, P. A. and Aviram, M. 1997. Antioxidant constituents from licorice roots: Isolation, structure elucidation and antioxidative capacity toward LDL oxidation. Free Radic. Biol. Med. 23, 241-251.
10 Wei, C. C., Yu, C. W., Yen, P. L., Lin, H. Y., Chang, S. T., Hsu, F. L. and Liao, V. H. 2014. Antioxidant activity, delayed aging, and reduced amyloid-${\beta}$ toxicity of methanol extracts of tea seed pomace from Camellia tenuifolia. J. Agric. Food. Chem. 62, 10701-10707.   DOI
11 Chu, Y. F., Brown, P. H., Lyle, B. J., Chen, Y., Black, R. M., William, C. E., Lin, Y. C., Hsu, C. W. and Cheng, I. H. 2009. Roasted coffees high in lipophilic antioxidant and chlorogenic acid lactones are more neuroprotective than green coffees. J. Agric. Food Chem. 57, 9801-9808.   DOI
12 Fujikawa, T., Yanaguchi, A., Mortia, I., Takeda, H. and Nishibe, S. 1996. Protective effects of Acanthpanax senticosus harms from hokkaido and its components on gastric ulcer in restrained cold water stressed rats. Biol. Pharm. Bull. 19, 1227-1230.   DOI
13 Gibson, B. W., Tang, D., Mandrell, R., Kelly, M. and Spindel, E. R. 1991. Bombinin-like peptides with antimicrobial activity from skin secretions of asian toad, Bombina orientalis. J. Biol. Chem. 266, 23103-23111.
14 Ha, B. J., Kim, H. J., Lee, S. H., Ha, J. M., Lee, S. H., Lee, J. H., Lee, D. G., Park, E. K. and Nam, C. S. 2005. The hepatoprotective effects of Epimedii herba through the antioxidation. J. Life Sci. 15, 572-577.   DOI
15 Havsteen, B. 1983. Flavonids, a class of natural products of high pharmacological potency. Biochem. Pharmacol. 32, 1141-1145.   DOI
16 Kim, H. B., Kim, S. Y., Ryu, K. S., Lee, W. C. and Moon, J. Y. 2001. Effect of methanol extract from mulberry fruit on the lipid metabolism and liver function in cholesterol-induced hyperlipidemia rat. Kor. J. Seric. Sci. 43, 104-108.
17 Huang, N. L. 2002. A mysterious medicinal fungus in russia: Innotus obliquus. Chinse J. Edible Mushroom 21, 7-8.
18 Jaramillo, M. C., Arango, G. J., Gonzalez, M. C., Robledo, S. M. and Velez, I. D. 2000. Cytotoxicity and antileishmanial activity of Annona muricata precarp. Fitoterpia 71, 183-186.   DOI
19 Ju, H. K., Chung, H. W., Hong, S. S., Park J. H., Lee, J. M. and Kwon, S. W. 2010. Effect of steam treatment of soluble phenolic content and antioxidant activity of the chaga mushroom (Innotus obliquus). Food Chem. 119, 619-325.   DOI
20 Jung, M. J., Yin, Y., Heo, S. I. and Wang. M. H. 2008. Antioxidant and anticancer activities of extract from Artemisia capillaries. Kor. J. Pharmacogn. 39, 194-198.
21 Kim, I. H., Lee, D. G., Lee, S. H., Ha, J. M., Ha B. J., Kim, S. G. and Lee, J. H. 2007. Antibacterial activity of Ulva lactuca against methicillin-resistant Staphylococcus aureus (MRSA). Biotechnol. Bioprocess. Eng. 12, 579-582.   DOI
22 Kim, K. W., Jung, S. H., Hwang, Y. J. and Park, J. K. 2015. Effect of medium molecular weight chitosan on antioxidant activity of Moringa oleifera. J. Chinin. Chitosan 20, 27-33.   DOI
23 Lee, H. J. and Chang, Y. C. 2012. Suppression of TNF-${\alpha}$- induced inflammation by extract from different parts of moringa in HaCaT cells. J. Life Sci. 22, 1254-1260.   DOI
24 Kitagaki, H. and Tsugama, M. 1999. 1-1-diphenyl-2-picrylhydrazyl radical (DPPH) scavenging ability of sake during storage. J. Biosci. Bioeng. 87, 328-332.   DOI
25 Klimek, J., Marsik, F., Bartlett, M., Weir, B., Shea, P. and Quintiliani, R. 1976. Clinical, epidemiological and bacteriologic observations of an outbreak of methicillin resistant Staphylococcus aureus at a large community hospital. Am. J. Med. 61, 340-345.   DOI
26 Kwon, Y. R. and Youn, K. S. 2014. Antioxidant activity and physiological properties (Morings oliefera Lam) leaves extracts with different solvents. Kor. J. Food Preserv. 21, 831-837.   DOI
27 Lee, J. H., Yang, J. E. and Chung, L. N. 2012. Sensory characteristic and drivers of liking for functional beverages. Kor. J. Food Cookery Sci. 28, 741-751.   DOI
28 Lim, S. Y., Leem, J. Y., Lee, C. S., Jang, Y. J., Park, J. W. and Yoon, S. 2007. Antioxidant and cell proliferation effect of Acanthopanax senticosus extract in human osteoblast-like MG-63 cell line. Kor. J. Food Sci. Technol. 39, 694-700.
29 Lee, J. W., Ji, Y. J., Yu, M. H., Im, H. G., Hwangbo, M. H. and Lee, I. S. 2005. Antimicrobial effect of extract of Glycyrrhiza uralensis on methicillin resistant Staphylococcus aureus. Kor. J. Food Sci. Technol. 37, 456-464.
30 Lehrer, R. I., Rosenmen, M., Harwig, S., Jackson, R. and Eisenhauer, P. 1991. Ultrasenstive assays for endogenous antimicrobial polypeptides. J. Immuno. Methods 137, 167-173.   DOI
31 Park, Y. K., Lee, H. B., Jeon, E. J., Jung, H. S. and Kang, M. H. 2004. Chaga mushroom extract inhibition oxidative DNA damage in human lymphocytes as assessed by comet assay. Biofactors 21, 109-112.   DOI
32 Lim, Y. G., Shin, J. Y., Kim, H., Baek, G. H., Yu, K. W., Jeong, H. S. and Lee, J. S. 2014. Anti-adipogenic effect of fermented coffee with Monascus ruber mycelium by slid state culture of green coffee beans. J. Kor. Soc. Food Sci. Nutr. 43, 624-629.   DOI
33 Park, S. H. and Chung, Y. C. 2012. Anti-fibrotic effects by moringa root extract in rat kidney fibroblast. J. Life Sci. 22, 1371-1377.   DOI
34 Park, S. W., Jung, Y. S. and Ko, K. C. 1997. Quantitative analysis of anthocyanins among mulberry cultivars and their pharmacological screening. J. Kor. Soc. Hort. Sci. 38, 722-724.
35 Santos, A. F. and Sant'Ana, A. E. G. 2001. Molluscicidal properties of some species of Annona. Phytomedicine 8, 115-120.   DOI
36 Shingleton, V. L., Orthofer, R. and Lamuela-Raventos, R. M. 1999. Analysis of total phenols and other oxidation substrates and antioxidants by means of folin-ciocalteu reagents. Methods Enzymol. 299, 152-178.