1 |
Zapata-Benavides, P., Mendez-Vazquez, J. L., GonzalezRocha, T. R., Zamora-Avila, D. E., Franco-Molina, M. A., Garza-Garza, R. and Rodriguez-Padilla, C. 2009. Expression of prostate apoptosis response (Par-4) is associated with progesterone receptor in breast cancer. Arch. Med. Res. 40, 595-599.
DOI
|
2 |
Zhao, Y., Burikhanov, R., Qiu, S., Lele, S. M., Jennings, C. D., Bondada, S., Spear, B. and Rangnekar, V. M. 2007. Cancer resistance in transgenic mice expressing the SAC module of Par-4. Cancer Res. 67, 9276-9285.
DOI
|
3 |
Zhao, Y. and Rangnekar, V. M. 2008. Apoptosis and tumor resistance conferred by Par-4. Cancer Biol. Ther. 7, 1867-1874.
DOI
|
4 |
Schneider, B. G., Rha, S. Y., Chung, H. C., Bravo, J. C., Mera, R., Torres, J. C., Plaisance, K. T. Jr., Schlegel, R., McBride, C. M., Reveles, X. T. and Leach, R. J. 2003. Regions of allelic imbalance in the distal portion of chromosome 12q in gastric cancer. Mol. Pathol. 56, 141-149.
DOI
|
5 |
Schwarze, S. and Rangnekar, V. M. 2010. Targeting plasma membrane GRP78 for cancer growth inhibition. Cancer Biol. Ther. 9, 153-155.
DOI
|
6 |
Sells, S. F., Wood, D. P. Jr., Joshi-Barve, S. S., Muthukumar, S., Jacob, R. J., Crist, S. A., Humphreys, S. and Rangnekar, V. M. 1994. Commonality of the gene programs induced by effectors of apoptosis in androgen-dependent and -independent prostate cells. Cell Growth Differ. 5, 457-466.
|
7 |
Srinivasan, S., Ranga, R. S., Burikhanov, R., Han, S. S. and Chendil, D. 2007. Par-4-dependent apoptosis by the dietary compound withaferin A in prostate cancer cells. Cancer Res. 67, 246-253.
DOI
|
8 |
Szegezdi, E., Logue, S. E., Gorman, A. M. and Samali, A. 2006. Mediators of endoplasmic reticulum stress-induced apoptosis. EMBO Rep. 7, 880-885.
DOI
|
9 |
Thayyullathil, F., Pallichankandy, S., Rahman, A., Kizhakkayil, J., Chathoth, S., Patel, M. and Galadari, S. 2013. Caspase-3 mediated release of SAC domain containing fragment from Par-4 is necessary for the sphingosine-induced apoptosis in Jurkat cells. J. Mol. Signal. 8, 2.
DOI
|
10 |
Thayyullathil, F., Rahman, A., Pallichankandy, S., Patel, M. and Galadari, S. 2014. ROS-dependent prostate apoptosis response-4 (Par-4) up-regulation and ceramide generation are the prime signaling events associated with curcumin-induced autophagic cell death in human malignant glioma. FEBS Open Bio. 4, 763-776.
DOI
|
11 |
Nalca, A., Qiu, S. G., El-Guendy, N., Krishnan, S. and Rangnekar, V. M. 1999. Oncogenic Ras sensitizes cells to apoptosis by Par-4. J. Biol. Chem. 274, 29976-29983.
DOI
|
12 |
Notaro, A., Sabella, S., Pellerito, O., Di Fiore, R., De Blasio, A., Vento, R., Calvaruso, G. and Giuliano, M. 2014. Involvement of PAR-4 in cannabinoid-dependent sensitization of osteosarcoma cells to TRAIL-induced apoptosis. Int. J. Biol. Sci. 10, 466-478.
DOI
|
13 |
Pereira, M. C., de Bessa-Garcia, S. A., Burikhanov, R., Pavanelli, A. C., Antunes, L., Rangnekar, V. M. and Nagai, M. A. 2013. Prostate apoptosis response-4 is involved in the apoptosis response to docetaxel in MCF-7 breast cancer cells. Int. J. Oncol. 43, 531-538.
DOI
|
14 |
Pruitt, K., Ulku, A. S., Frantz, K., Rojas, R. J., Muniz-Medina, V. M., Rangnekar, V. M., Der, C. J. and Shields, J. M. 2005. Ras-mediated loss of the pro-apoptotic response protein Par-4 is mediated by DNA hypermethylation through Raf-independent and Raf-dependent signaling cascades in epithelial cells. J. Biol. Chem. 280, 23363-23370.
DOI
|
15 |
Qiu, G., Ahmed, M., Sells, S. F., Mohiuddin, M., Weinstein, M. H. and Rangnekar, V. M. 1999. Mutually exclusive expression patterns of Bcl-2 and Par-4 in human prostate tumors consistent with down-regulation of Bcl-2 by Par-4. Oncogene 18, 623-631.
DOI
|
16 |
Rah, B., Amin, H., Yousuf, K., Khan, S., Jamwal, G., Mukherjee, D. and Goswami, A. 2012. A novel MMP-2 inhibitor 3-azidowithaferin A (3-azidoWA) abrogates cancer cell invasion and angiogenesis by modulating extracellular Par-4. PLoS One. 7, e44039.
DOI
|
17 |
Kogel, D., Reimertz, C., Mech, P., Poppe, M., Fruhwald, M. C., Engemann, H., Scheidtmann, K. H. and Prehn, J. H. 2001. Dlk/ZIP kinase-induced apoptosis in human medulloblastoma cells: requirement of the mitochondrial apoptosis pathway. Br. J. Cancer 85, 1801-1808.
DOI
|
18 |
Rayet, B. and Gelinas, C. 1999. Aberrant rel/nfkb genes and activity in human cancer. Oncogene 18, 6938-6947.
DOI
|
19 |
Kline, C. L. and Irby, R. B. 2011. The pro-apoptotic protein Prostate Apoptosis Response Protein-4 (Par-4) can be activated in colon cancer cells by treatment with Src inhibitor and 5-FU. Apoptosis 16, 1285-1294.
DOI
|
20 |
Kogel, D., Plottner, O., Landsberg, G., Christian, S. and Scheidtmann, K. H. 1998. Cloning and characterization of Dlk, a novel serine/threonine kinase that is tightly associated with chromatin and phosphorylates core histones. Oncogene 17, 2645-2654.
DOI
|
21 |
Lee, A. S. 2009. The Par-4-GRP78 TRAIL, more twists and turns. Cancer Biol. Ther. 8, 2103-2105.
|
22 |
Lee, T. J., Jang, J. H., Noh, H. J., Park, E. J., Choi, K. S. and Kwon, T. K. 2010. Overexpression of Par-4 sensitizes TRAIL-induced apoptosis via inactivation of NF-kappaB and Akt signaling pathways in renal cancer cells. J. Cell. Biochem. 109, 885-895.
|
23 |
Lee, T. J., Lee, J. T., Kim, S. H., Choi, Y. H., Song, K. S., Park, J. W. and Kwon, T. K. 2008. Overexpression of Par-4 enhances thapsigargin-induced apoptosis via down-regulation of XIAP and inactivation of Akt in human renal cancer cells. J. Cell. Biochem. 103, 358-368.
DOI
|
24 |
Moreno-Bueno, G., Fernandez-Marcos, P. J., Collado, M., Tendero, M. J., Rodriguez-Pinilla, S. M., Garcia-Cao, I., Hardisson, D., Diaz-Meco, M. T., Moscat, J., Serrano, M. and Palacios, J. 2007. Inactivation of the candidate tumor suppressorpar-4 in endometrial cancer. Cancer Res. 67, 1927-1934.
DOI
|
25 |
Jagtap, J. C., Parveen, D., Shah, R. D., Desai, A., Bhosale, D., Chugh, A., Ranade, D., Karnik, S., Khedkar, B., Mathur, A., Natesh, K., Chandrika, G. and Shastry, P. 2015. Secretory prostate apoptosis response (Par)-4 sensitizes multicellular spheroids (MCS) of glioblastoma multiforme cells to tamoxifen-inducedcell death. FEBS Open Bio. 5, 8-19.
DOI
|
26 |
Goswami, A., Burikhanov, R., de Thonel, A., Fujita, N., Goswami, M., Zhao, Y., Eriksson, J. E., Tsuruo, T. and Rangnekar, V. M. 2005. Binding and phosphorylation of par-4 by akt is essential for cancer cell survival. Mol. Cell 20, 33-44.
DOI
|
27 |
Gurumurthy, S., Goswami, A., Vasudevan, K. M. and Rangnekar, V. M. 2005. Phosphorylation of Par-4 by protein kinase A is critical for apoptosis. Mol. Cell. Biol. 25, 1146-1161.
DOI
|
28 |
Jagtap, J. C., Dawood, P., Shah, R. D., Chandrika, G., Natesh, K., Shiras, A., Hegde, A. S., Ranade, D. and Shastry, P. 2014. Expression and regulation of prostate apoptosis response-4 (Par-4) in human glioma stem cells in drug-inducedapoptosis. PLoS One. 9, e88505.
DOI
|
29 |
Johnstone, R. W., See, R. H., Sells, S. F., Wang, J., Muthukkumar, S., Englert, C., Haber, D. A., Licht, J. D., Sugrue, S. P., Roberts, T., Rangnekar, V. M. and Shi, Y. 1996. A novel repressor, par-4, modulates transcription and growth suppression functions of the Wilms’ tumor suppressor WT1. Mol. Cell. Biol. 16, 6945-6956.
DOI
|
30 |
Johnstone, R. W., Tommerup, N., Hansen, C., Vissing, H. and Shi, Y. 1998. Mapping of the human PAWR (par-4) gene to chromosome 12q21. Genomics 53, 241-243.
DOI
|
31 |
Kimura, M., Furukawa, T., Abe, T., Yatsuoka, T., Youssef, E. M., Yokoyama, T., Ouyang, H., Ohnishi, Y., Sunamura, M., Kobari, M., Matsuno, S. and Horii, A. 1998. Identification of two common regions of allelic loss in chromosome arm 12q in human pancreatic cancer. Cancer Res. 58, 2456-2460.
|
32 |
Diaz-Meco, M. T., Municio, M. M., Frutos, S., Sanchez, P., Lozano, J., Sanz, L. and Moscat, J. 1996. The product of par-4, a gene induced during apoptosis, interacts selectively with the atypical isoforms of protein kinase C. Cell 86, 777-786.
DOI
|
33 |
de Thonel, A., Hazoume, A., Kochin, V., Isoniemi, K., Jego, G., Fourmaux, E., Hammann, A., Mjahed, H., Filhol, O., Micheau, O., Rocchi, P., Mezger, V., Eriksson, J. E., Rangnekar, V. M. and Garrido, C. 2014. Regulation of the proapoptotic functions of prostate apoptosis response-4 (Par-4) by casein kinase 2 in prostate cancer cells. Cell Death Dis. 5, e1016.
DOI
|
34 |
Diaz-Meco, M. T., Lallena, M. J., Monjas, A., Frutos, S. and Moscat, J. 1999. Inactivation of the inhibitory kappaB protein kinase/nuclear factor kappaB pathway by Par-4 expression potentiates tumor necrosis factor alpha-induced apoptosis. J. Biol .Chem. 274, 19606-19612.
DOI
|
35 |
Diaz-Meco, M. T. and Moscat, J. 2008. Akt regulation and lung cancer: a novel role and mechanism of action for the tumor suppressor Par-4. Cell Cycle 7, 2817-2820.
DOI
|
36 |
Donninger, H., Hesson, L., Vos, M., Beebe, K., Gordon, L., Sidransky, D., Liu, J. W., Schlegel, T., Payne, S., Hartmann, A., Latif, F. and Clark, G. J. 2010. The Ras effector RASSF2 controls the PAR-4 tumor suppressor. Mol. Cell. Biol. 30, 2608-2620.
DOI
|
37 |
Downward, J. 2004. PI 3-kinase, Akt and cell survival. Semin. Cell Dev. Biol. 15, 177-182.
DOI
|
38 |
El-Guendy, N. and Rangnekar, V. M. 2003. Apoptosis by Par-4 in cancer and neurodegenerative diseases. Exp. Cell Res. 283, 51-66.
DOI
|
39 |
El-Guendy, N., Zhao, Y., Gurumurthy, S., Burikhanov, R. and Rangnekar, V. M. 2003. Identification of a unique core domain of par-4 sufficient for selective apoptosis induction in cancer cells. Mol. Cell. Biol. 23, 5516-5525.
DOI
|
40 |
Boehrer, S., Chow, K. U., Puccetti, E., Ruthardt, M., Godzisard, S., Krapohl, A., Schneider, B., Hoelzer, D., Mitrou, P. S., Rangnekar, V. M. and Weidmann, E. 2001. Deregulated expression of prostate apoptosis response gene-4 in less differentiated lymphocytes and inverse expressional patterns of par-4 and bcl-2 in acute lymphocytic leukemia. Hematol. J. 2, 103-107.
DOI
|
41 |
Bos, J. L. 1989. ras oncogenes in human cancer: a review. Cancer Res. 49, 4682-4689.
|
42 |
Burikhanov, R., Zhao, Y., Goswami, A., Qiu, S., Schwarze, S. R. and Rangnekar, V. M. 2009. The tumor suppressor Par-4 activates an extrinsic pathway for apoptosis. Cell 138, 377-388.
DOI
|
43 |
Chakraborty, M., Qiu, S. G., Vasudevan, K. M. and Rangnekar, V. M. 2001. Par-4 drives trafficking and activation of Fas and Fasl to induce prostate cancer cell apoptosis and tumor regression. Cancer Res. 61, 7255-7263.
|
44 |
Chaudhry, P., Singh, M., Parent, S. and Asselin, E. 2012. Prostate apoptosis response 4 (Par-4), a novel substrate of caspase-3 during apoptosis activation. Mol. Cell. Biol. 32, 826-839.
DOI
|
45 |
Cheema, S. K., Mishra, S. K., Rangnekar, V. M., Tari, A. M., Kumar, R. and Lopez-Berestein, G. 2003. Par-4 transcriptionally regulates Bcl-2 through a WT1-binding site on the bcl-2 promoter. J. Biol. Chem. 278, 19995-20005.
DOI
|
46 |
Cook, J., Krishnan, S., Ananth, S., Sells, S. F., Shi, Y., Walther, M. M., Linehan, W. M., Sukhatme, V. P., Weinstein, M. H. and Rangnekar, V. M. 1999. Decreased expression of the pro-apoptotic protein Par-4 in renal cell carcinoma. Oncogene 18, 1205-1208.
DOI
|
47 |
Ahmed, M. M., Sheldon, D., Fruitwala, M. A., Venkatasubbarao, K., Lee, E. Y., Gupta, S., Wood, C., Mohiuddin, M. and Strodel, W. E. 2008. Downregulation of PAR-4, a pro-apoptotic gene, in pancreatic tumors harboring K-ras mutation. Int. J. Cancer 122, 63-70.
DOI
|
48 |
Barkett, M. and Gilmore, T. D. 1999. Control of apoptosis by Rel/NF-kappaB transcription factors. Oncogene 18, 6910-6924.
DOI
|
49 |
Almoguera, C., Shibata, D., Forrester, K., Martin, J., Arnheim, N. and Perucho, M. 1988. Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes. Cell 53, 549-554.
DOI
|
50 |
Azmi, A. S., Ahmad, A., Banerjee, S., Rangnekar, V. M., Mohammad, R. M. and Sarkar, F. H. 2008. Chemoprevention of pancreatic cancer: characterization of Par-4 and its modulation by 3,3′ diindolylmethane (DIM). Pharm. Res. 25, 2117-2124.
DOI
|
51 |
Barradas, M., Monjas, A., Diaz-Meco, M. T., Serrano, M. and Moscat, J. 1999. The downregulation of the pro-apoptotic protein Par-4 is critical for Ras-induced survival and tumor progression. EMBO J. 18, 6362-6369.
DOI
|