Browse > Article
http://dx.doi.org/10.5352/JLS.2015.25.6.638

Biological Activities of Mesembryanthemum crystallinum (Ice plant) Extract  

Lee, Sang Yull (Department of Biochemistry, Pusan National University School of Medicine)
Choi, Hyeun Deok (Department of Microbiology and Immunology, Pusan National University School of Medicine)
Yu, Sun Nyoung (Department of Microbiology and Immunology, Pusan National University School of Medicine)
Kim, Sang Hun (Department of Microbiology and Immunology, Pusan National University School of Medicine)
Park, Seul Ki (Department of Microbiology and Immunology, Pusan National University School of Medicine)
Ahn, Soon Cheol (Department of Microbiology and Immunology, Pusan National University School of Medicine)
Publication Information
Journal of Life Science / v.25, no.6, 2015 , pp. 638-645 More about this Journal
Abstract
This study analyzed the physiological quality of Mesembryanthemum crystallinum (ice plant) extract. M. crystallinum is a succulent plant found in Africa, southern Europe, North America, South America, and Australia. It has known antidiabetic, antioxidant, and activation of lipid metabolism effects. Extracts from M. crystallinum were prepared with methanol (MCM), ethanol (MCE), hot water (MCHW), and methanol after hot water (MCHM) extractions. The yields of MCM, MCE, MCHW, and MCHM were 0.37, 0.33, 0.50, and 0.07%, respectively. To determine the biological activities of the extracts, mushroom tyrosinase, pancreatic lipase, 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging, nitric oxide (NO) production, and α-glucosidase assays were conducted. The DPPH radical scavenging activity of the MCHW extract was 62.9% at a concentration of 400 μg/ml, which was the highest of all the extracts. The MCM extract showed the highest inhibition activity of α-glucosidase and NO production (56.6 and 57.2%, respectively). The pancreatic lipase inhibition of the MCE extract was similar to that of the MCM extract, with significant inhibition of 90%. The mushroom tyrosinase inhibition of all the extracts was very low (approximately 30%). These results suggest that extracts from M. crystallinum have antioxidant, anti-inflammatory, antiobesity, and antidiabetic activities. Thus, it may have potential as a functional food product and therapeutic potential as an antidiabetic or antiobesity agent.
Keywords
Anti-diabetics; anti-obesity; ice plant; Mesembryanthemum crystallinum; nitric oxide production;
Citations & Related Records
Times Cited By KSCI : 5  (Citation Analysis)
연도 인용수 순위
1 Lim, S., Lee, H. K., Park, K. S. and Cho, S. I. 2005. Changes in the characteristics of metabolic syndrome in Korea over the period 1998-2001 as determined by Korean National Health and Nutrition Examiation Surverys. Diabetes Care 28, 1810-1812.   DOI
2 Turkmen, N., Sari, F. and Velioglu, Y. S. 2005. The effect of cooking methods on total phenolics and antioxidant activity of selected green vegetables. Food Chem. 93, 713-718.   DOI
3 Weisz, A., Cicatiello, I. and Esumi, H. 1996. Regulation of the mouse inducible-type nitric oxide synthase gene promoter by interferon-gamma, bacterical lipopolysaccharide and NG- monomethyl-L-arginine. Biochem. J. 316, 209-215.   DOI
4 Yu, M. H., Im, H. G., Lee, H. J., Ji, Y. J. and Lee, I. S. 2006. Components and their antioxidative activities of methanol extracts from sarcocarp and seed of Zizypus jujuba var. inermis Rehder. Kor. J. Food Sci. Technol. 38, 128-134.
5 Rahman, M. A. A. and Moon, S. S. 2007. Antioxidant polyphenol glycosides from the plant Draba nemorosa. Bull. Kor. Chem. Soc. 28, 827-831.   DOI
6 Seo, W. G., Pae, H. O., Oh, G. S., Chai, K. Y., Yun, Y. G. and Kwon, T. O. 2000. Inhibitory effects of ethyl acetate fraction from Cudrania tricuspidata on the expression of nitric oxide synthase gene in RAW 264.7 macrophages stimulated with interferon and lipopolysaccharide. Gen. Pharmacol. 35, 21-28.   DOI
7 Birari, R. B. and Bhutani, K. K. 2007. Pancreatic lipase inhibitors from natural sources: unexplored potential. Drug Discov. Today 12, 879-889.   DOI
8 Ancerewicz, J., Migliavacca, E., Carrupt, P. A., Testa, B., Bree, F., Zini, R., Tillement, J. P., Labidalle, S., Guyot, D., Chauvet-Monges, A. M, Crevat, A. and Le Ridant, A. 1998. Structure-property relationships of trimetazidine derivativesand model compounds as potential antioxidants. Free Radic. Biol. Med. 25, 113-120.   DOI
9 Bahn, K. N., Lee, C. H., Cho, T. Y., Lee, J. Y., Lee, Y. J. and Chae, G. Y. 2005. Determination of phosphatidylcholine in Korea functional foods contatining lecitins using HPLC with evaporative light-scattering detector (ELSD). J. Fd. Hyg.Safety 20, 267-271.
10 Bates, S. H., Jones, R. B. and Bailey, C. J. 2000. Insulin-like effect of pinitol. Br. J. Pharmacol. 130, 1944-1948.   DOI
11 Ortmeyer, H. K., Huang, L. C., Zhang, H. L., Hansen, B. C. and Larner, J. 1993. Chiro-inositol deficiency and insulin resistance. II. Acute effect of D-chiro-inositol administration in streptozotocin-diabetic rats, normal rats given a glucoseload and spontaneously insulin-resistance in spontaneously diabetic rhesus monkeys. Endocrinology 132, 646-651.
12 Lim, S. S., Shin, K. H., Bang, H. S., Kim, Y. P., Jung, S. H., Kim, Y. J. and Ohuchi, K. 2002. Effect of the essential oil from the flowers of Magnolia sieboldii on the lipopolysaccharide-induced production of nitric oxide and prostaglandin E2 by rat peritoneal macrophages. Planta Med. 68, 459-462.   DOI
13 McCartney-Francis, N., Allen, J. B., Mizel, D. E., Albina, J. E., Xie, Q. W. and Nathan, C. F. 1993. Suppression of arthritis by an inhibitor of nitic oxide synthase. J. Exp. Med. 178, 749-754.   DOI
14 Posadas, I., Terencio, M. C., Guillen, I., Ferrandiz, M. L., Coloma, J. and Paya, M. 2000. Co-regulation between cyclo-oxygenase-2 and inducible nitric oxide synthase expression in the time-course of murine inflammation. Naunyn Schmiedebergs Arch. Pharmacol. 361, 98-106.   DOI
15 Pak, Y., Huang, L. C., Lilley, K. J. and Larner, J. 1992. In vivo conversion of myo- inositol to chiro-inositol in rat tissues. J. Biol. Chem. 267, 16904-16910.
16 Pak, Y., Hong Y., Kim, S., Piccariello, T., Farese, R. V. and Larner, J. 1998. In vivo chiro- inositol metabolism in rat: A defect in chiro-inositol synthesis from myo-inositol and an increased incorporation of chiro-inositol into phospholipids in the Goto-Kakizaki (G. K.) rat. Mol. Cells 8, 301-309.
17 Jun, H. I., Wiesenborn, D. P. and Kim, Y. S. 2011. Antioxidant activities of various solvent extracts from canola meal. Kor. J. Food Preserv. 18, 59-64.   DOI
18 Kwon, Y. S., Jeon, I. S., Hwang. J. H., Lim, D. M., Kang, Y. S. and Chung, H. J. 2009. Biological activities of Maca (Lepidium meyenii) extracts. J. Kor. Soc. Food Sci. Nutr. 38, 817-823.   DOI
19 Kang, M. H., Cho, C. S., Kim, Z. S., Chung, H. K., Min, K. S., Park, C. G. and Park, H. W. 2002. Antioxidative activities of ethanol extract prepared from leaves, seed, branch and aerial part of Crotalaria sessiflora L. Kor. J. Food Sci.Technol. 34, 1098-1102.
20 Kim, H. Y., Woo, K. S., Hwang, I. G., Lee, Y. R. and Jeong, H. S. 2008. Effects of heat treatments on the antioxidant activities of fruits and vegetables. Kor. J. Food Sci. Technol. 40, 166-170.
21 Kim, J. H., Kim, H. J., Kim, C. Y., Jung, H. Y., Kim, Y. O., Ju, J. Y. and Shin, C. S. 2007. Development of lipase inhibitors from various derivatives of monascus pigment produced by Monascus fermentation. Food Chem. 101, 357-364.   DOI
22 Kim, J. S., Kwon, C. S. and Son, K. H. 2000. Inhibition of alpha-glucosidase and amylase by luteolin, a flavonoid. Biosci. Biotechnol. Biochem. 64, 2458-2461.   DOI
23 Kim, Y. J. and Uyama, H. 2005. Tyrosinase inhibitors from natural and synthetic sources: structure, inhibition mechanism and perspective for the future. Cell. Mol. Life Sci. 62, 1707-1723.   DOI
24 Lee, B. G., Kim, S. H., Zee, O. P., Lee, K. R., Lee, H. Y. and Han, J. W. 2000. Suppression of inducible nitric oxide synthase expression in RAW 264.7 macrophages by two-carboline alkaloids extracted from Melia azedarach. Eur. J. Pharmacol. 406, 301-309.   DOI
25 Bouftira, I., Abdelly, C. and Sfar, S. 2008 Characterization of cosmetic cream with Mesembryanthemum crystallinum plant extract: influence of formulation composition on physical stability and anti-oxidant activity. Int. J. Cosmet. Sci. 30, 443-452.   DOI
26 Choi, Y., Lee, S. M., Chun, J., Lee, H. B. and Lee, J. 2006. Influence of heat treatment on the antioxidant activities and polyphenolic compounds of Shiitake (Lentinus edodes) mushroom. Food Chem. 99, 381-387.   DOI
27 Cha, J. Y., Cho, Y. S., Kim, I., Anno, T., Rahman, S. M. and Yanagita, T. 2001. Effect of hesperetin, a citrus flavonoid, on the liver triacylglycerol content and phosphatidate phosphohydrolase activity in orotic acid-fed rats. Plant Foods Hum. Nutr. 56, 349-358.   DOI
28 Chiou, W. F., Chou, C. J. and Chen, C. F. 2001. Camptothecin suppresses nitric oxide biosynthesis in RAW 264.7 macrophages. Life Sci. 69, 625-635.   DOI
29 Hong, Y. S., Lee, K. H., Lee, H. S., Lee, M. S., Jee, S. H. and Joung, H. J. 2007. Association between compliance with dietary guidelines and dyslipidemia among Koreans. Kor. J. Nutr. 40, 745-752.
30 Dong, S., Jung, S. H., Moon, J. S., Rhee, S. K. and Son, J. Y. 2004. Antioxidant activities of clove by extraction solvent. J. Kor. Soc. Food Sci. Nutr. 33, 609-613.   DOI
31 Hearing, V. J. 1987. Mammalian monophenol monooxygenase (tyrosinase): purification, properties and reaction catalyzed. Meth. Enzymol. 142, 154-165.   DOI
32 Jeong, D. H., Kim, K. B. W. R., Kim, M. J., Kang, B. K. and Ahn, D. H. 2013. Anti-inflammatory activity of ethanolic extract of Sargassum micracanthum. J. Microbiol. Biotechnol. 23, 1691-1698.   DOI
33 Adisakwattana, S., Chantarasinlapin, P., Thammarat, H. and Yibchok-Anun, S. 2009. A series of cinnamic acid derivatives and their inhibitory activity on intestinal alpha-glucosidase. J. Enzyme Inhib. Med. Chem. 24, 1194-1200.   DOI   ScienceOn
34 Ahn, I. S., Park, K. Y. and Do, M. S. 2007. Weight control mechanisms and antiobesity functional agents. J. Kor. Soc. Food Sci. Nutr. 36, 503-513.   DOI