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http://dx.doi.org/10.5352/JLS.2015.25.4.456

Effects of Fermented Sargassum thunbergii on Platelet Aggregation and Serum Lipid Levels in Obese Rat induced by High Fat Diet  

Cheon, Jihyeon (Department of Food and Nutrition, Silla University)
Lee, Juyeong (Department of Food and Nutrition, Silla University)
Kim, Jihye (Department of Food and Nutrition, Silla University)
Park, Mi-Hwa (Department of Food and Nutrition, Silla University)
Lee, Sang-Hyeon (Department of Pharmaceutical Engineering, Silla University)
Kong, Changsuk (Department of Food and Nutrition, Silla University)
Kim, Yuck Yong (ISFOOD Co. LTD.)
Yu, Ki Hwan (ISFOOD Co. LTD.)
Kim, Mihyang (Department of Food and Nutrition, Silla University)
Publication Information
Journal of Life Science / v.25, no.4, 2015 , pp. 456-462 More about this Journal
Abstract
We investigated the effects of fermented Sargassum thunbergii (FST) on platelet aggregation and serum lipid levels in rats made obese by a high fat diet. Six-week-old male SD-rats were randomly assigned to four groups as CON, HF-CON induced by high fat diet (HF), ST supplemented with HF (HFST100), and the fermented ST supplemented with HF group (HF-FST100). After 6 weeks, the results showed that the final weight and weight gain had decreased in the HF- FST100 group compared to the HF-CON group. Also, the food efficiency ratio was significantly reduced in the HF-FST100 group compared to HF-CON. The organ weights other than heart and spleen were significantly lower in the HF-FST100 group than in the HF-CON group. The levels of serum GOT and GPT significantly decreased in the HF-FST100 group over the HF-CON group. In addition, the total cholesterol, triglyceride and LDL-cholesterol levels were lower in the HF-FST100 group than in HF-CON, while the HDL-cholesterol level was higher in the HF-FST100. The ability of platelet aggregation of groups supplemented with FST was lower than the HF-CON group. These results suggest that FST may be beneficial in improving lipid profile and platelet aggregation in obesity.
Keywords
Fermentation; obese rats; platelet aggregation; Sargassum thunbergii; serum lipids;
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