Vitamin C Promoted Liver Regeneration Following Partial Hepatectomy-induced Hepatic Injury in Senescence Marker Protein-30-deficient Mice
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Han, Seon Young
(Department of Pathology, College of Veterinary Medicine, Kyungpook National University)
Hwang, Meeyul (Department of Pathology, College of Veterinary Medicine, Kyungpook National University) Kim, Ah-Young (Department of Pathology, College of Veterinary Medicine, Kyungpook National University) Lee, Eun-Mi (Department of Pathology, College of Veterinary Medicine, Kyungpook National University) Lee, Eun-Joo (Department of Pathology, College of Veterinary Medicine, Kyungpook National University) Lee, Myeong-Mi (Department of Pathology, College of Veterinary Medicine, Kyungpook National University) Sung, Soo-Eun (Department of Pathology, College of Veterinary Medicine, Kyungpook National University) Kim, Sang-Hyeob (Department of Pathology, College of Veterinary Medicine, Kyungpook National University) Jeong, Kyu-Shik (Department of Pathology, College of Veterinary Medicine, Kyungpook National University) |
1 | Michalopoulos, G. K. 2007. Liver regeneration. J. Cell Physiol. 213, 286-300. DOI |
2 | Kondo, Y., Sasaki, T., Sato, Y., Amano, A., Aizawa, S., Iwama, M., Handa, S., Shimada, N., Fukuda, M., Akita, M., Lee, J., Jeong, K. S., Maruyama, N. and Ishigami, A. 2008. Vitamin C depletion increases superoxide generation in brains of SMP30/GNL knockout mice. Biochem. Biophys. Res. Commun. 377, 291-296. DOI ScienceOn |
3 | Leu, J. I., Crissey, M. A., Craig, L. E. and Taub, R. 2003. Impaired hepatocyte DNA synthetic response posthepatectomy in insulin-like growth factor binding protein 1-deficient mice with defects in C/EBP beta and mitogen-activated protein kinase/extracellular signal-regulated kinase regulation. Mol. Cell Biol. 23, 1251-1259. DOI |
4 | Mapson, L. W. 1961. The estimation of dehydro-L-ascorbic acid when present in low concentration in tissues by the Roe and Kuether procedure. Ann. N. Y. Acad. Sci. 92, 284-285. DOI |
5 | Michalopoulus, G. K. and Defrances, M. C. 1997. Liver regeneration. Science 276, 60-66. DOI |
6 | Michalopoulos, G. K. and Khan, Z. 2005. Liver regeneration, growth factors and amphiregulin. Gastroenterology 128, 503-506. DOI |
7 | Nakamura, T. 1994. Hepatocyte growth factor as mitogen, motogen and morphogen and its roles in organ regeneration. Princess Takamatsu Symp. 24, 195-213. |
8 | Nathwani, R. A., Pais, S., Reynolds, T. B. and Kaplowitz, N. 2005. Serum alanine aminotransferase in skeletal muscle disease. Hepatology 41, 380-382. DOI |
9 | Park, J. K., Jeong, D. H., Park, H. Y. Son, K. H., Shin, D. H., Do, S. H., Yang, H. J., Yuan, D. W., Hong, I. H., Goo, M. J., Lee, H. R., Ki, M. R., Ishigami, A. and Jeong, K. S. 2008. Hepatoprotective effect of Arazyme on CCl4-induced acute hepatic injury in SMP30 knockout mice. Toxicology 246, 132-142. DOI |
10 | Fujita, T., Uchida, K. and Maruyama, N. 1996. Isolation and characterization of genomic and cDNA clones encoding mouse senescence marker protein-30 (SMP30). Biochem. Biophys. Acta 1308, 49-57. |
11 | Fan, G., Xu, R., Wessendorf, M. W., Ma, X., Kren, B. T. and Steer, C. J. 1995. Modulation of retinoblastoma and retinoblastoma-related proteins in regenerating rat liver and primary hepatocytes. Cell Growth Differ. 6, 1463-1476. |
12 | Fausto, N. 2006. Liver regeneration. Hepatology 43, S45-S53. DOI |
13 | Fujita, T., Uchida, K. and Maruyama, N. 1992. Purification of senescence marker protein-30 (SMP30) and its androgen-independent decrease with age in the rat liver. Biochim. Biophys. Acta 1116, 122-128. DOI |
14 | Grimes, C. A. and Jope, R. S. 2001. The multifaceted roles of glycogen synthase kinase 3 beta in cellular signaling. Prog. Neurobiol. 65, 391-426. DOI |
15 | Gruppuso, P. A. 1989. Expression of hepatic transforming growth factor receptors during late gestation in the fetal rat. Endocrinology 125, 3037-3043. DOI |
16 | Bohmer, J. A., Sellhause, B. and Schrage, N. F. 2001. Effect of ascorbic acid on retinal pigment epithelial cells. Curr. Eye Res. 23(3), 206-214. DOI |
17 | Ishigami, A., Fujita, T., Handa, S., Shirasawa, T., Koseki, H., Kitamura, T., Enomoto, N., Sato, N., Shimosawa, T. and Maruyama, N. 2002. Senescence marker protein-30 knockout mouse liver is highly susceptible to tumor necrosis factor-alphaand Fas-mediated apoptosis. Am. J. Pathol. 161, 1273-1281. DOI |
18 | Jeong, J. J., Heo, S. H., Kim, J. H., Yoon, K. H., Lee, Y. J., Han, K. B. and Kim, W. J. 2010. Effects of rrhGM-CSF on Morphology and expression of PCNA in regenerating rat liver. Kor. J. Microscopy 40, 73-80. |
19 | Albrecht, J. H. and Hansen, L. K. 1999. Cyclin D1 promotes mitogen-independent cell cycle progression in hepatocytes. Cell Growth Differ. 10, 397-404. |
20 | Arrigoni, O., Arrigoni-Liso, R. and Calabrese, G. 1976. Ascorbic acid as a factor controlling the development of cyanide-insensitive respiration. Science 194, 332-333. DOI ScienceOn |
21 | Attisano, L., Carcamo, J., Ventura, F., Weis, F. M., Massagué, J. and Wrana, J. L. 1993. Identificat ion of human activin and TGFβ type Ⅰ receptors that form heteromeric kinase complexes with type Ⅱ receptors. Cell 75, 671-680. DOI |
22 | Behrens, A. and Sibilia, M. 2002. Impaired postnatal hepatocyte proliferation and liver regeneration in mice lacking c-jun in the liver. EMBO J. 21, 1782-1790. DOI |
23 | Borowiak, M., Garratt, A. N., Wustefeld, T., Strehle, M., Trautwein, C. and Birchmeier, C. 2004. Met provides essential signals for liver regeneration. Proc. Natl. Acad. Sci. USA 101, 10608-10613. DOI |
24 | Traber, M. G. and Stevens, J. F. 2011. Vitamin C and E: Beneficial effects from a mechanistic perspective. Free Radic. Biol. Med. 51, 1000-1013. DOI |
25 | Braun, L., Mead, J. E., Panzica, M., Mikumo, R., Bell, G. I. and Fausto, N. 1988. Transforming growth factor-β mRNA increases during liver regeneration: a possible paracrine mechanism of growth regulation. Proc. Natl. Acad. Sci. USA 85, 1539-1543. DOI |
26 | Chen, H., Yang, S., Yang, Z., Ma L, Jiang, D., Mao, J., Jiao, B. and Cai, Z. 2007. Inhibition of GSK-3beta decreases NF-kappaB-dependent gene expression and impairs the rat liver regeneration. J. Cell Biochem. 102, 1281-1289. DOI |
27 | Cressman, D. E. and Greenbaum, L. E. 1996. Liver failure and defective hepatocyte regeneration in interleukin 6-deficient mice. Science 274, 1379-1383. DOI |
28 | Woodgett, J. R. 1990. Molecular cloning and expression of glycogen synthase kinase 3/factor A. EMBO J. 9, 2431-2438. |
29 | Taira, Z., Shiraishi, M. and Ueda, Y. 2005. An abnormal proliferation at day four on 70% partial hepatectomy of rats. J. Hard Tissue Biology (supplement) 14, 351-352. DOI |
30 | Xiong, Y., Connolly, T., Futcher, B. and Beach, D. Human D-type cyclin. 1991. Cell 65, 691-699. DOI |
31 | Yeoh, G. C., Ernst, M., Rose-John, S., Akhurst, B., Payne, C., Long, S., Alexander, W., Croker, B., Grail, D. and Matthews, V. B. 2007. Opposing roles of gp130-mediated STAT-3 and ERK-1/2 signaling in liver progenitor cell migration and proliferation. Hepatology 45, 486-494. DOI |
32 | Price, C. E. 1996. Ascorbate stimulation of RNA synthesis. Nature 212, 1481. |
33 | Talarmin, H., Rescan, C., Cariou, S., Glaise, D., Zanninelli, G., Bilodeau, M., Loyer, P., Guguen-Guillouzo, C. and Baffet, G. 1999. The mitogen-activated protein kinase kinase/extracellular signal-regulated kinase cascade activation is a key signalling pathway involved in the regulation of G(1) phase progression in proliferating hepatocytes. Mol. Cell Biol. 19, 6003-6011. DOI |
34 | Pulverer, B. J., Kyriakis, J. M., Avruch, J., Nikolakaki, E. and Woodgett, J. R. 1991. Phosphorylation of c-jun mediated by Map kinase. Nature 353, 670-674. DOI |
35 | Servillo, G. and Penna, L. 1997. Cyclic AMP signalling pathway and cellular proliferation: induction of CREM during liver regeneration. Oncogene 14, 1601-1606. DOI |
36 | Stain, A. J., Frazer, A., Hill, D. J. and Milner, R. D. 1987. Transforming growth factor β inhibits DNA synthesis in hepatocytes isolated from normal and regenerating rat liver. Biochem. Biophys. Res. Commun. 145, 436-442. DOI |
37 | Taub, R. 2004. Liver regeneration: from myth to mechanism. Nat. Rev. Mol. Cell Biol. 5, 836-847. DOI ScienceOn |
38 | Seth, A., Gonzalez, F. A., Gupta, S., Raden, D. L. and Davis, R. J. 1992. Signal transduction within the nucleus by mitogen-activated protein kinase. J. Biol. Chem. 267, 24796-24804. |
39 | Shakoori, A., Mai, W., Miyashita, K., Yasumoto, K., Takahashi, Y., Ooi, A., Kawakami, K. and Minamoto, T. 2007. Inhibition of GSK-3 beta activity attenuates proliferation of himan colon cancer cells in rodents. Cancer Sci. 98, 1388-1393. DOI |
40 | Spiewak Rinaudo, J. A. and Thorgeirsson, S. S. 1997. Detection of a tyrosine-phosphorylated form of cyclin A during liver regeneration. Cell Growth Differ. 8, 301-309. |
41 | Strain, A. J. and Hill, D. J. 1990. Changes in sensitivity of hepatocytes isolated from regenerating rat liver to the growth inhibitory action of transforming growth factor beta. Liver 10, 282-290. |
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