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http://dx.doi.org/10.5352/JLS.2015.25.1.29

Anti-MRSA Properties of Prodigiosin from Serratia sp. PDGS 120915  

Ji, Keunho (Department of Microbiology, Pukyong National University)
Jeong, Tae Hyug (Department of Microbiology, Pukyong National University)
Kim, Young Tae (Department of Microbiology, Pukyong National University)
Publication Information
Journal of Life Science / v.25, no.1, 2015 , pp. 29-36 More about this Journal
Abstract
Prodigiosin, a member of natural red pigment family, is produced by Serratia marcescens, and characterized by a common pyrrolylpyrromethane skeleton. This pigment has been reported with the effects of anticancer, immunosuppressant, antifungal, and algicidal activities. Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of hospital infections. In this study, anti-MRSA properties of prodigiosin isolated from Serratia sp. PDGS 120915 were investigated. We identified and purified prodigiosin using high performance liquid chromatography (HPLC) and evaluated anti-MRSA activity. Purified prodigiosin inhibited the growth of MRSA. The minimum inhibitory concentrations (MICs) of prodigiosin were determined to $32{\mu}g/ml$ against the MRSA strains. Fractional inhibitory concentration (FIC) indices of ampicillin and penicillin were indicated synergistic effects of prodigiosin on MRSA.
Keywords
Anti-MRSA; prodigiosin; red pigment; Serratia;
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