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http://dx.doi.org/10.5352/JLS.2014.24.9.959

Preparation of Functional Healthy Drinks by Acanthopanax senticosus Extracts  

Sung, Mi-Sun (Research Center, Chong Kun Dang Healthcare Corporation)
Jung, Hoe-Yune (Pohang Center for Evaluation of Biomaterials)
Choi, Jun-Hyeok (Research Center, Chong Kun Dang Healthcare Corporation)
Lee, Sung-Cheol (Research Center, Chong Kun Dang Healthcare Corporation)
Choi, Bo-Hwa (Pohang Center for Evaluation of Biomaterials)
Park, Sung Sun (Research Center, Chong Kun Dang Healthcare Corporation)
Publication Information
Journal of Life Science / v.24, no.9, 2014 , pp. 959-966 More about this Journal
Abstract
This study was carried out to develop a functional healthy drink using 60% ethanol of dried Acanthopanax senticosus stem extract (ASE). The preparation, physical activity, anti-oxidant activity, and sensory properties of ASE were investigated. The moisture, crude protein, crude lipid, and ash contents of dried ASE were $6.50{\pm}0.12%$, $5.89{\pm}0.16%$, $1.18{\pm}0.11%$, and $3.03{\pm}0.40%$ respectively. The 1,1-Diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity was $87.42{\pm}1.63%$ at 1/10 folds diluted ASE. In total, 40 male ICR mice were divided into five groups including the control (PBS), positive control (Red ginseng 200 mg/kg/day), and ASE-treated groups at doses of 35, 70, and 140 mg/kg/day for five weeks, respectively. ASE was administrated orally one time per day for five weeks before treadmill exercises, and normal and positive controls were fed PBS and red ginseng extract. In the treadmill test, ASE-treated mice (140 mg/kg/day) could run 1.4 times longer than the control mice. Healthy drinks were prepared with the addition of ASE at levels of 0.97% or 0.49% (A, B, and C type). Among the healthy drinks, the B type (ASE, 0.97%) was revealed to have the highest level of taste and overall acceptability through a sensory evaluation. The brix and pH of the ASE health drink (B type) were 14.9 and 4.51, respectively. These results indicated that the dried stem of Acanthopanax senticosus could be used as a functional material in the health drink industry.
Keywords
Acanthopanax senticosus stem extract; exercise performance; health drink; quality characteristic;
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Times Cited By KSCI : 18  (Citation Analysis)
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1 Brekhman, I. I. and Dardymov, I. V. 1969. Pharmacological investigation of glycosides from ginseng and Eleutherococcus. Lloydia 32, 46-51.
2 Baczek, K. 2009. Accumulation of biologically active compounds in Eleuthero (Eleutherococcus senticosus/Rupr. et Maxim./Maxim/) grown in Poland. Herba pol 55, 7-12.
3 Blosis, M. S. 1958. Antioxidant determinations by the use of a stable free radical. Nature 181, 1199-1200.   DOI   ScienceOn
4 Brekhman, I. I. and Dardmov, I. V. 1969. New substances of plant origin which increase nonspecific resistance. Annu Rev Pharmacol 9, 419-430.   DOI   ScienceOn
5 Cho, H. Y., Chung, S. J., Kim, H. S. and Kim, K. O. 2005. Effect of sensory characteristics and non-sensory factors on consumer linking of various canned tea products. J Food Sci 70, 532-538.   DOI   ScienceOn
6 Choi, J. M. and Ahn, J. B. 2012. Functional properties of 50% methanol extracts from different parts of Acanthopanax sessiliflorus. Korean J Food Sci Technol 44, 373-377.   DOI   ScienceOn
7 Choi, J. M., Kim, K. Y., Lee, S. H. and Ahn, J. B. 2011. Functional properties of water extracts from different parts of Acanthopanax sessiliflorus. Food Eng Prog 15, 130-135.
8 Choi, Y. H. and Kim, J. 2002. Quantitative analysis of eleutherosides B and E using HPLC-ESI/MS. Korean J Pharmacogn 33, 88-91.
9 FDA. 2005. Guidance for Industry: Estimating the Maximum Safe Starting Dose in Initial Clinical Trials for Therapeutics in Adult Healthy Volunteers. pp 1-27, Rockville, MD, US.
10 Fujikawa, T., Miguchi, S., Kanada, N., Nakai, N., Ogata, M., Suzuki, I. and Nadashima, K. 2005. Acanthopanax senticosus Harms as a prophylactic for MPRP-induced Parkinson's disease in rats. J Ethnopharmacol 97, 375-381.   DOI   ScienceOn
11 Huang, L. Z., Huang, B. K., Ye, Q. and Qin, L. P. 2011. Bioactivity-guided fractionation for anti-fatigue property of Acanthopanax senticosus. J Ethnopharmacol 133, 213-219.   DOI   ScienceOn
12 Hahn, D. R., Kim, C. J. and Kim, J. H. 1985. A study on chemical constituents of Acanthopanax koreanum Nakai and its pharmaco-biological activities. Yakhak Hoeji 29, 357-361.
13 Heo, S. J., Ahn, H. Y., Kang, M. J., Lee, J. H., Cha, J. Y. and Cho, Y. S. 2011. Antioxidative activity and chemical characteristics of leaves, roots, stems and fruits extracts from Acanthopanax senticosus. J Life Sci 21, 1052-1059.   DOI
14 Hong, S. P., Jeong, H. S., Jeong, E. J. and Shin, D. H. 2006. Quality characteristic of beverage with Gastroda elata blume extract. J Fd Hyg Safety 21, 31-35.
15 Huang, L. Z., Huang, B. K., Liang, J., Zheng, C. J., Han, T., Zhang, Q. Y. and Qin, L. P. 2011. Antifatigue activity of the liposoluble fraction from Acanthopanax senticosus. Phytother Res 25, 940-943.   DOI   ScienceOn
16 Hwang, J. B., Yang, M. O. and Shin, H. K. 1997. Survey for approximate composition and mineral content of medicinal herbs. Korean J Food Sci Technol 29, 671-679.
17 Kim, J. H., Kim. J. K., Kang, W. W., Kim, G. Y., Choi, M. S. and Moo, K. D. 2003. Preparation of functional healthy drinks by ethanol extracts from defatted safflower seed cake. J Korean Soc Food Sci Nutr 32, 1039-1045.   DOI
18 Jammes, Y., Steinberg, J. G., Mambrini, O., Bregeon, F. and Delliaux, S. 2005. Chronic fatigue syndrome: assessment of increased oxidative stress and altered muscle excitability in response to incremental exercise. J Intern Med 257, 299-310.   DOI
19 Jo, B. C. and Cho, Y. J. 2012. Biological activity of extracts from Acanthopanax sessiliflorum fruit. Korean J Food Preserv 19, 586-593.   DOI   ScienceOn
20 Jung, G. C., Yeom, C. H., Cho, B. L. and Choi, J. S. 2006. The effect of intravenous vitamin C in People with Fatigue. J Korean Acad Fam Med 27, 391-395.
21 Jung, H. J., Park, H. J., Kim, R. G., Shin, K. M., Ha, J., Choi, J. W., Kim, H. J., Lee, Y. S. and Lee, K. T. 2003. In vivo anti-inflammatory and antinoceptive effects of lirodendrin isolated from the stem bark of Acanthopanax senticosus. Planta Med 69, 610-616.   DOI   ScienceOn
22 Jung, H. Y., Lee, A. N., Song, T. J., An, H. S., Kim, Y. H., Kim, K. D., Kim, I. B., Kim, K. S., Han, B. S., Kim, C. H., Kim, K. S. and Kim, J. B. 2012. Korean mistletoe (Viscum album coloratum) extract improves endurance capacity in mice by stimulating mitochondrial activity. J Med Food 15, 621-628.   DOI   ScienceOn
23 Jwa, C. S., Yang, Y. T. and Koh, J. S. 2000. Changes in eleutherosides conents of Acanthopanax koreanum by harvest time. Korean J Postharvest Sci Technol 7, 362-365.
24 Kim, Y. J., Jung, U. J., Lee, G. D. and Choi, M. S. 2012. Effects of herbal sports drinks containing Prunus mume fruit extract on the plasma lipid profile and endurance of rats. J Korean Soc Food Sci Nutr 41, 1409-1416.   DOI   ScienceOn
25 Kim, J. H., Park, H. J., Park, S. D., Choi, S. Y., Seong, J. H. and Moon, K. D. 2002. Preparation and antioxidant activity of health drink with extract powders from Safflower (Carthamus tinctorus L.) seed. Korean J Food Sci Technol 34, 617-624.
26 Kim, L. H., Han, S. S. and Choi, Y. S. 2002. Antioxidant effects of the extracts of Acanthopanax senticosus. Korean J Pharm 33, 359-363.
27 Kim, S. D., Lee, S. I. and Shin, K. O. 2005. Effect of Acanthopanax senticosus extracts of blood sugar and serum lipid profiles of streptozotocin-induced diabetic rats. J East Asian Soc Diet Life 15, 549-557.
28 Lee, J. H., Yang, J. E. and Chung, L. 2012. Sensory characteristic and drivers of liking for functional beverages. Korean J Food Cook Sci 28, 741-751.   DOI
29 Kimura, Y. and Sumiyoshi, M. 2004. Effects of various Eleutherococcus senticosus cortex on swimming time, natural killer activity and corticosterone level in forced swimming stressed mice. J Ethnopharmacol 95, 447-453.   DOI   ScienceOn
30 Kou, J., Chen, K. W. C., Cheng, I. S., Tsai, P. H., Lu, Y. J. and Lee, N. Y. 2010. The effect of eight weeks of supplementation with Eleutherococcus senticosus on endurance capacity and metabolism in human. Chin J physiol 523, 105-111.
31 Lee, S. G., Yu, M. H., Lee, S. P. and Lee, I. S. 2008. Antioxidant activities and induction of apoptosis by methanol extracts from avocado. J Korean Soc Food Sci Nutr 37, 269-275.   DOI
32 Park, H. R., Park, E., Rim, A. R., Jeon, K. I., Hwang, J. H. and Lee, S. C. 2006. Antioxidant activity of extracts from Acanthopanx senticosus. African J Biotechnol 5, 2388-2396.
33 Lee, S., Shin, D. S., Oh, K. B. and Shin, K. H. 2003. Antibacterial compounds from the leaves of Acanthopanax senticosus. Arch Pharm Res 26, 40-42.   DOI
34 Logan, A. C. and Wong, C. 2001. Chronic fatigue syndrome: Oxidative stress and dietary modification. J Clin Ther 6, 450-459.
35 Oh, S. L., Kim, S. S., Min, B. Y. and Chung, D. H. 1990. Composition of free sugars, free amino acids, non-volatile organic acids and tannis in the extracts of L. chinensis M., A. acutiloba K., S, chinensis B. and A. sessiliflorum S. Korean J Food Sci Technol 22, 76-81.
36 Wang, W. R., Lin, R., Zhang, H., Lin, Q. Q., Yang, L. N., Zhang, K. F. and Ren, F. 2011. The effects of Buyang Huanwu Decoction on hemorheological disorders and energy metabolism in rats with coronary heart disease. J Ethnopharmacol 137, 214-220.   DOI
37 Yokozawa, T., Rhyu, D. Y., Chen, C. P. 2003. Protective effects of Acanthopanax Radix extract against endotoxemia induced by lipopolysaccharide. Phytother Res 17, 353-357.   DOI
38 Yook, C. S., Rho, Y. S., Seo, S. H., Leem, J. Y. and Han, D. R. 1996. Chemical components of Acanthopanax divaricatus and anticancer effect in leaves. Yakhak Hoeji 40, 251-261.
39 Yoon, S. J., Kim, K. H., Kim, C. J., Park, H. C., Kang, K. H., Kim, M. J., Kang, S. M., Kwak, U. H. and Kim, H. J. 2008. Effects of red ginseng supplementation on aerobic, anaerobic performance, central and peripheral fatigue. J Ginseng Res 32, 210-219.   DOI
40 Zhang, X. L., Ren, F., Huang, W., Ding, R. T., Zhou, Q. S. and Liu, X. W. 2011. Anti-fatigue activity of extracts of stem bark from Acanthopanax senticosus. Molecules 16, 28-37.
41 Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., Messadeq, N., Milne, J., Lambert, P., Elliott, P., Geny, B., Laakso, M., Puigserver, P. and Auwerx, J. 2006. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell 127, 1109-1122.   DOI   ScienceOn
42 AOAC. 1995. Official methods of analysis, pp 32-1-13, 16th ed, Association of Official Analytical Chemists, Washington, DC, USA.