Browse > Article
http://dx.doi.org/10.5352/JLS.2014.24.6.642

Therapeutic Effect of Toothpaste Containing Hydroxyapatite and Tribasic Calcium Phosphate on Dentinal Hypersensitivity  

Choi, Yea Hun (Department of Life Science & Environmental Biochemistry, Pusan National University)
Park, Hyean Cheal (Department of Life Science & Environmental Biochemistry, Pusan National University)
Lee, Sang Mong (Department of Life Science & Environmental Biochemistry, Pusan National University)
Son, Hong Joo (Department of Life Science & Environmental Biochemistry, Pusan National University)
Choi, Eun Bi (Department of Life Science & Environmental Biochemistry, Pusan National University)
Ha, Jun Young (Department of Life Science & Environmental Biochemistry, Pusan National University)
Lee, Jun Young (Department of Life Science & Environmental Biochemistry, Pusan National University)
Kim, Keun Ki (Department of Life Science & Environmental Biochemistry, Pusan National University)
Publication Information
Journal of Life Science / v.24, no.6, 2014 , pp. 642-647 More about this Journal
Abstract
Although it is not a pathological symptom, Dentinal Hypersensitivity (DH) describes pain felt by patients whose tooth roots are exposed outside of the gums and are therefore sensitive to external stimuli. DH is caused by tooth brushing or gum diseases and treatment to reduce the sensitivity can include use of materials having stimulation activity for DH or a resin material applied periodontally. This study examined the hypersensitivity treatment effects of a four-week treatment with a toothpaste containing hydroxyapatite and tricalcium phosphate (Hap-TCP toothpaste). The Hap-TCP toothpaste was made by mixing a commercially available fluorine-containing toothpaste with 10% (W/W) hydroxyapatite and 19% (W/W) tricalcium phosphate (both 99% purity based on XRD analysis). The tooth hypersensitivity treatment effect was surveyed by scoring VRS values, and showed no significant initial difference compared with the control. However, after 1 week of use, the pain reduction value was 8% in the treatment group compared to the control group. This value increased to 30% and 60% after 2 and 4 weeks, respectively. Hypersensitivity to cold stimulation, which was used as a VAS value, showed no initial significant differences compared with the control, but was significantly decreased after 1, 2, and 4 weeks in the experimental group, with more than a 3-fold difference after 4 weeks. These findings confirmed that remineralization can alleviate DH as hydroxyapatite fills dentinal tubules and calcium, phosphorus, and tricalcium phosphate ion equilibrium is established.
Keywords
Dentinal Hypersensitivity (DH); hydroxyapatite; remineralization; toothpaste; tricalcium phosphate;
Citations & Related Records
Times Cited By KSCI : 3  (Citation Analysis)
연도 인용수 순위
1 Bren, M. 1986. The hydrodynamic theory of pain: Sensation in preparation, caries, and the dentinal crack syndrome. J Endod 12, 453-457.   DOI   ScienceOn
2 Carini, F., Scardina, G. A., Leone, A., Messina, P. and Valenza, V. 2007. Effects of ferric oxalate dentin desensitizer : SEM analysis. Res J Biol Sci 2, 147-149.
3 Cummins, D. 2009. Dentin hypersensitivity: from diagnosis to a breakthrough therapy for everyday sensitivity relief. J Clin Dent 20, 1-9.
4 Duran, I. and Sengun, A. 2004. The long-term effectiveness of five current desensitizing products on cervical dentine sensitivity. J Oral Rehabil 31, 351-356.   DOI   ScienceOn
5 Gillam, D. G., Coventry, J. F., Manning, R. H., Newman, H. N. and Bulman, J. S. 1997. Comparison of two desensitizing agents for the treatment of cervical dentine sensitivity. Endod Dent Traumatol 13, 36-39.   DOI
6 Jacobsen P. L. and Bruce G. 2001. Clinical dentin hypersensitivity : understanding the cause and prescribing a treatment. J Contemp Dent Pract 15, 1-12.
7 Jang, S. O., Kim, D. K. and Ko, Y. M. 2007 Clinical evaluation of dentinal hypersensitivity treatment containing potassium phosphate and ursodeoxycholic acid. J Korean Res Soc Dent Mater 34, 89-97.
8 Park, J. J., Park, J. B., Kwon, Y. H., Herr, Y. and Chung, J. H. 2005. The effects of microcrystalline hydroxyapatite containing toothpaste in the control of tooth hypersensitivity. J Korean Acad Periodontol 35, 577-590.   DOI
9 Tal, H., Kozlovsky, A., Artzi, Z., Nemcovsky, C. E. and Moses, O. 2008. Long-term bio-degradation of cross-linked and non-cross-linked collagen barriers in human guided bone regeneration. Clin Oral Implants Res 19, 295-302.   DOI
10 Tonetti, M. S., Cortellini, P., Lang, N. P., Suvan, J. E., Adriaens, P., Dubravec, D., Fonzar, A., Fourmousis, I., Rasperini, G., Silvestri, M., Topoll, H., Wallkamm, B. and Zybutz, M. 2004. Clinical outcomes following treatment of human intrabony defects with GTR/bone replacement material or access flap alone. J Clin Periodontol 31, 770-776.   DOI
11 Pashley, D. H. and Galloway, S. E. 1985. The effects of oxalate treatment on the smear layer of ground surfaces on human dentin. Arch Oral Biol 30, 731-737.   DOI   ScienceOn
12 Walters, P. A. 2005. Dentinal hypersensitivity: a review. J Contemp Dent Prac 6, 1-10.
13 Orsini, G., Scarano, A., Degidi, M., Caputi, S., Iezzi, G. and Piattelli, A. 2007. Histological and ultrastructural evaluation of bone around Bio-Oss particles in sinus augmentation. Oral Dis 13, 586-593.   DOI
14 Pamir, T., Dalgar, H. and Onal, B. 2007. Clinical evaluation of three desensitizing agents in relieving dentin hypersensitivity. Oper Dent 32, 544-548.   DOI
15 Ricarte, J. M., Matoses, V., Llácer, V. J. F., Fernández, A. J. F. and Moreno, B. M. 2008. Dental sensitivity: Concept and methodology for its objective evaluation. Med Oral Patol Oral Cir Bucal 13, E201-E206.
16 Richmond, N. L. 1993. Dental hypersensitivity: Recent advances in diagnosis and treatment. J Indiana Dent Assoc 72, 20-22.
17 Schiff, T., He, T., Sagae, L. and Baker, R. 2006. Efficacy and safety of a novel stabilized stannous fluoride and sodium hexametaphosphate dentrifice for dental hypersensitivity. J Contemp Dent Pract 7, 1-10.
18 Lee, S. H., Song, S. I., Han, J. Y., Hwang, K. G., Paik, S. S. and Shim, K. S. 2004. The experimental study of the bone regeneration on $\beta$-TCP in rabbit cranial bone. J Korean Assoc Oral Maxillofac Surg 30, 282-291.   과학기술학회마을
19 Kang, S. J., Kwon, Y. H., Park, J. B., Herr, Y. and Chung, J. H. 2009. The effects of hydroxyapatite toothpaste on tooth hypersensitivity. J Korean Acad Periodontol 39, 9-16.   과학기술학회마을
20 Kim, S. 1986. Hypersensitivity teeth: Desensitization of pulpal sensory nerves. J Endod 12, 482-485.   DOI   ScienceOn
21 Kim, S. H, Park, J. B., Lee, C. W., Koo, K. T., Kim, T. I., Seol, Y. J., Lee, Y. M., Ku, Y., Chung, C. P. and Rhyu, I. C. 2009. The clinical effects of a hydroxyapatite containing toothpaste for dentine hypersensitivity. J Korean Acad Periodontol 39, 87-94.   과학기술학회마을
22 Lee, S. Y., Kwon, H. K. and Kim, B. I. 2008. Effect of dentinal tubule occlusion by dentifrice containing nano-carbonate apatite. J Oral Rehabil 35, 847-853.   DOI   ScienceOn
23 Marini, I. and Greenspan, D. 2006. Pilot clinical study evaluating efficacy of NovaMin-containing dentifrice for relief of dentin hypersensitivity. NavaMin Research Report. Novamin Technology Inc.
24 Merika, K., HeftitArthur, F. and Preshaw, P. M. 2006. Comparison of two topical treatments for dentine sensitivity. Eur J Prosthodont Restor Dent 14, 38-41.
25 Minkoff, S. and Axelrod, S. 1987. Efficacy of strontium chloride in dental hypersensitivity. J Periodontol 58, 470-474.   DOI
26 Morris, M. F., Davis, R. D. and Richardson, B. W. 1999. Clinical efficacy of two dentin desensitizing agents. Am J Dent 12, 72-76.
27 Nevins, M., Camelo, M., De Paoli, S., Friedland, B., Schenk, R. K., Parma-Benfenati, S., Simion, M., Tinti, C. and Wagenberg, B. 2006. A study of the fate of the buccal wall of extraction sockets of teeth with prominent roots. The Int J Periodontics Restorative Dent 26, 19-29.
28 Brannstrom, M. 1966. Sensitivity of dentine. Oral Surg Oral Med Oral Pathol 21, 517-526.   DOI   ScienceOn