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http://dx.doi.org/10.5352/JLS.2014.24.3.284

Inhibitory Effects of Phyllostachys bambusoides on Melanin Synthesis and Tyrosinase Activity in Cultured Human Melanoma Cells  

Huh, Man Kyu (Department of Molecular Biology, College of Natural Sciences, Dongeui University)
Han, Min Ho (Department of Biochemistry, Dongeui University College of Oriental Medicine)
Park, Cheol (Department of Molecular Biology, College of Natural Sciences, Dongeui University)
Choi, Yung Hyun (Department of Biochemistry, Dongeui University College of Oriental Medicine)
Publication Information
Journal of Life Science / v.24, no.3, 2014 , pp. 284-289 More about this Journal
Abstract
Tyrosinase is a rate-limiting enzyme that controls the production of melanin. The effect of bamboo (Phyllostachys bambusoides) on tyrosinase activity and melanin synthesis has not been studied. We analyzed the effects of leaf and inner film fractions of bamboo extracts on the inhibition of tyrosinase activity and on melanin production. At a concentration of 5 mg/ml, the extracts of bamboo down-regulated the production of melanocytes. In addition, the extracts of bamboo reduced tyrosinase activity and the melanin content in vitro. Our results suggest that bamboo extract may constrain melanin synthesis by inhibition of the activity and expression of tyrosinase.
Keywords
Bamboo; extractions; melanocyte; tyrosinase activity; melanin;
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