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http://dx.doi.org/10.5352/JLS.2014.24.11.1200

Protective Effects of Crude Mucin and Saponin from Dioscorea Rhizoma on Gastric Ulcer Induced by Alcohol in Rats  

Park, Young Mi (Department of Biological Science, Andong National University)
Lim, Jae Hwan (Department of Biological Science, Andong National University)
Jeong, Hyung Jin (Department of Medicinal Plant Resource, Andong National University)
Seo, Eul Won (Department of Biological Science, Andong National University)
Publication Information
Journal of Life Science / v.24, no.11, 2014 , pp. 1200-1208 More about this Journal
Abstract
The aim of this study was to investigate the effect of crude mucin and saponin from Dioscorea Rhizoma on acute gastric ulcers in rats. The gastric ulcer group (GU group) and mucin-applied group (DR-M group) exhibited serious bleeding of the mucous membrane of the stomach due to the ulcers, as well as blood congestion for three days. The saponin-applied group (DR-S group) exhibited less mucous membrane bleeding, and reddened and inflamed membranes recovered dramatically within 24 hours. After developing an acute pgastric ulcer, the tissues of the stomach, intestine, and liver in the control group and the DR-M group exhibited edema in the submucous membrane, as well as serious bleeding. However, the DR-S group recovered quickly from mucous membrane bleeding due to gastric ulcer. The DR-M group did not show any notable changes in serum formation or activity of antioxidant enzymes compared to the GU rats. Increased AST and ALT activities were detected from the first day with saponin application in the gastric ulcer rats. As the AST and ALT activities decreased, the gastric ulcers recovered with the increased activities of the antioxidant enzymes. Accordingly, this study suggest that mucin in Dioscorea Rhizomahas no effect on the recovery of damaged stomachs due to gastric ulcers, but saponin is mainly responsible for decreasing tissue damage by activating antioxidant enzymes.
Keywords
Dioscorea Rhizoma; gastric ulcer; mucin; saponin;
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