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http://dx.doi.org/10.5352/JLS.2014.24.10.1151

Immune-modulation Effect of Ulmus macrocarpa Hance Water Extract on Balb/c Mice  

Lee, Inhwan (Department of Clinical Laboratory Science, Dong-Eui University)
Kwon, Da Hye (Department of Food and Nutrition, Dong-Eui University)
Lee, Sun Hee (Research Center for Anti-aging Technology Development, Dong-Eui University)
Lee, Sung Do (Department of Clinical Laboratory Science, Dong-Eui University)
Kim, Deok Won (Department of Clinical Laboratory Science, Dong-Eui University)
Lee, Jong-Hwan (Department of Biotechnology and Bioengineering, Dong-Eui University)
Hyun, Sook Kyung (Department of Food and Nutrition, Dong-Eui University)
Kang, Kyung-Hwa (Department of Korean Physiology, Dong-Eui University)
Kim, CheolMin (School of Medicine, Pusan National University)
Kim, Byoung Woo (Department of Applied Life Science, Dong-Eui University)
Hwang, Hye Jin (Department of Food and Nutrition, Dong-Eui University)
Chung, Kyung Tae (Department of Clinical Laboratory Science, Dong-Eui University)
Publication Information
Journal of Life Science / v.24, no.10, 2014 , pp. 1151-1156 More about this Journal
Abstract
Traditional medicinal plants are widely used to treat many diseases, such as inflammation, infections, and even cancer. Ulmus macrocarpa Hance, a Chinese elm species, is distributed in Korea, China, and Japan. The stem bark is widely employed in Korean traditional medicine to treat dermatitis, mastitis, and edema. The aim of this study was to investigate whether water extract of U. macrocarpa Hance bark (Ulmus cortex) has a immune-modulating function in a mouse model. Three different concentrations (30 mg/kg, 100 mg/kg, and 300 mg/kg) of Ulmus cortex water extract (UCWE) were orally administered to mice for 14 days, and their immune responses were analyzed. Cytokines, such as interleukin (IL)-2, IL-12, and IFN-${\gamma}$, increased in the blood of UCWE-fed groups when compared with a control group. In contrast, the IL-4 level did not change in any of the UCWE-fed groups Cell-mediated cytotoxicity was also assayed using lymphokine-activated killer cells (LAK). LAK showed greater cytotoxicity in the UCWE-fed groups than LAK in the control group. Internal organ indices, such as liver, kidney, spleen, and thymus, were similar in all the groups, including the control group, indicating that UCWE may have been nontoxic in the experimental animals. These data suggest that UCWE has an immune-modulating function in a mouse model.
Keywords
Cytokines; immune-modulation; LAK (lymphokine-activated killer) cells; Ulmus macrocarpa Hance;
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