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http://dx.doi.org/10.5352/JLS.2014.24.10.1070

Histological Changes in the Accessory Reproductive Organs and Liver of Male Mice in Response to Short-term Treatment with an Estrogen Receptor Agonist  

Mo, Yun Jeong (Department of Biology, College of Bio-industry Science, Sunchon National University)
Cho, Young Kuk (Department of Laboratory Medicine, Seoyeong University)
Cho, Hyun Wook (Department of Biology, College of Bio-industry Science, Sunchon National University)
Publication Information
Journal of Life Science / v.24, no.10, 2014 , pp. 1070-1077 More about this Journal
Abstract
In this study, the estrogen receptor agonist propyl pyrazole triol (PPT), which has high-affinity with the estrogen receptor alpha, was subcutaneously injected into adult male mice every 2 days for 8, 16 and 24 days, after which histological changes in accessory genital glands, including the prostate and seminal vesicle, and the liver were observed. The body and genital gland weights decreased in the PPT group relative to those of the control group. However, the liver weight was two times greater in the PPT group. The luminal area of the prostate and seminal vesicle organs was lower in the PPT group, and the epithelial cell height of the prostate was increased relative to that of the control. There were many secretory vacuoles in the supranuclear cytoplasm of epithelial cells in the seminal vesicles of the control group, but these were not observed in the PPT group. The short sinusoidal diameter of the liver was 147.0%, 198.7%, and 223.3% greater in the PPT group than in the control group after 8, 16, and 24 days of treatment, respectively. These results suggest that PPT administration affected the reproductive organs and the liver and that the histological changes increased in accordance with a rise in the concentration of PPT. Overall, the PPT treatment caused changes in the epithelial cell height and resulted in atrophy of the luminal area of the prostate, leading to altered fertility. The sinusoidal diameter of the liver dramatically increased in response to the administration of PPT, increasing the liver weight.
Keywords
Liver; male mouse; PPT (propyl pyrazole triol); prostate; seminal vesicle;
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