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http://dx.doi.org/10.5352/JLS.2013.23.9.1104

Regulation of Unfolded Protein Response by Ethylene Glycol in Rat  

Lee, Eun Ryeong (Department of Biomedical Laboratory Science, College of health & Welfare, Kyungwoon University)
Kwon, Kisang (Department of Biomedical Laboratory Science, College of health & Welfare, Kyungwoon University)
Publication Information
Journal of Life Science / v.23, no.9, 2013 , pp. 1104-1108 More about this Journal
Abstract
Ethylene glycol (EG) is the most commonly used for automotive antifreeze, and it's easily misuseful for human. EG poisoning occurs in suicide attempts and infrequently, either intentionally through misuse or accidentally because of sweet taste. Though EG itself is mild toxic to the human body, it becomes higher toxic organic acids by in vivo broken down that are responsible for extensive cellular damage in various tissues caused principally by the metabolites. It is already well known that various cellular stresses induce gene expression of endoplasmic reticulum (ER) chaperones and ER stress sensors. This study demonstrated that regulation of gene expression of ER chaperones and ER stress sensors was induced by EG in rat tissues, and in tissues histological changes are also detected by both staining H&E and immunofluorescent.
Keywords
Ethylene glycol (EG); endoplasmic reticulum (ER) chaperones; ER stress sensors;
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Times Cited By KSCI : 2  (Citation Analysis)
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