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http://dx.doi.org/10.5352/JLS.2013.23.6.789

Improvement Effect of Fermented Silkworm (Bombyx mori L.) Powder against Orotic Acid-induced Fatty Liver in Rats  

Ahn, Hee-Young (Department of Medical Biosciences, Graduate School, Dong-A University)
Cha, Jae-Young (Technical Research Institute, Daesun Distilling Co., Ltd.)
Park, Kyu-Rim (Department of Medical Biosciences, Graduate School, Dong-A University)
Kim, Yu-Ra (Department of Biotechnology, Dong-A University)
Cho, Young-Su (Department of Biotechnology, Dong-A University)
Publication Information
Journal of Life Science / v.23, no.6, 2013 , pp. 789-795 More about this Journal
Abstract
Current study was to investigate the potential effects of silkworm, Bombyx mori L. fermented with Bacillus subtilis (BFSP) and Aspergillus kawachii (AFSP) at the 5% (w/w) levels in Sprague-Dawley rats, which was intoxicated with 1% (w/w) orotic acid (OA) for 10 days. The rat group administered silkworm powder showed improvements in fatty liver condition. Consumption of fermented silkworm powder reduced triglyceride concentrations in the liver tissues and serum and increased the serum lipid concentrations to normal levels, thereby aiding in improving fatty liver conditions. These effects were more pronounced in the BFSP than that in SP or AFSP in orotic acid-induced hepatotoxicity and oxidative stress. Based on these results, fermented silkworms are considered to be a material with significant potential for development into a functional health food that can improve fatty liver conditions.
Keywords
Bombyx mori L.; Bacillus subtilis; Aspergillus kawachii; fermentation; orotic acid; fatty liver;
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Times Cited By KSCI : 7  (Citation Analysis)
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