Pro-apoptotic Effects of Platycodin D Isolated from Platycodon grandiflorum in Human Leukemia Cells
![]() |
Park, Sang Eun
(Department of Internal Medicine, Dongeui University College of Oriental Medicine)
Lee, Su Young (Department of Internal Medicine, Dongeui University College of Oriental Medicine) Shin, Dong Yeok (Department of Biochemistry, Dongeui University College of Oriental Medicine) Jeong, Jin-Woo (Department of Biochemistry, Dongeui University College of Oriental Medicine) Jin, Myung Ho (Department of Internal Medicine, Dongeui University College of Oriental Medicine) Park, Seon Young (Department of Internal Medicine, Dongeui University College of Oriental Medicine) Chung, Yoon Ho (Duksan B&F Co. LTD.) Hwang, Hye Jin (Department of Food and Nutrition, College of Human Ecology, Dongeui University) Hong, Sang Hoon (Department of Internal Medicine, Dongeui University College of Oriental Medicine) Choi, Yung Hyun (Department of Biochemistry, Dongeui University College of Oriental Medicine) |
1 | Antonsson, B. and Martinou, J. C. 2000. The Bcl-2 protein family. Exp Cell Res 256, 50-57. DOI ScienceOn |
2 | Chang, H., Lin, H., Yi, L., Zhu, J., Zhou, Y., Mi, M. and Zhang, Q. 2010. 3,6-Dihydroxyflavone induces apoptosis in leukemia HL-60 cell via reactive oxygen species-mediated p38 MAPK/JNK pathway. Eur J Pharmacol 648, 31-38. DOI ScienceOn |
3 |
Choi, C. Y., Kim, J. Y., Kim, Y. S., Chung, Y. C., Seo, J. K. and Jeong, H. G. 2001. Aqueous extract isolated from platycodon grandiflorum elicits the release of nitric oxide and tumor necrosis factor- |
4 | Donovan, M. and Cotter, T. G. 2004. Control of mitochondrial integrity by Bcl-2 family members and caspase-independent cell death. Biochim Biophys Acta 1644, 133-47 DOI ScienceOn |
5 | Kaufmann, S. H., Desnoyers, S., Ottaviano, Y., Davidson, N. E. and Poirier, G. G. 1993. Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy- induced apoptosis. Cancer Res 53, 3976-3985. |
6 | Khan, N., Adhami, V. M. and Mukhtar, H. 2008. Apoptosis by dietary agents for prevention and treatment of cancer. Biochem Pharmacol 76, 1333-1339. DOI ScienceOn |
7 | Konishi, T., Tada, A., Shoji, J. and Tanaka, O. 1976. The structures of platycodin A and C, monoacetylated saponins of the roots of Platycodon grandiflorum. Chem Pharm Bull(ToKyo) 26, 668-670. |
8 | Ghobrial, I. M., Witzig, T. E. and Adjei, A. A. 2005. Targeting apoptosis pathways in cancer therapy. CA Cancer J Clin 55, 178-194. DOI ScienceOn |
9 | Gilliland, D. G., Jordan, C. T. and Felix, C. A. 2004. The molecular basis of leukemia. Hematology Am Soc Hematol Educ Program 80-97. |
10 | Han, S. I., Kim, Y. S. and Kim, T. H. 2008. Role of apoptotic and necrotic cell death under physiologic conditions. BMB Rep 41, 1-10. 과학기술학회마을 DOI ScienceOn |
11 | Holcik, M., Gibson, H. and Korneluk, R. G. 2001. XIAP:apoptotic brake and promising therapeutic targe. Apoptosis 6, 253-261. DOI ScienceOn |
12 | Hussein, M. R., Haemel, A. K. and Wood, G. S. 2003. Apoptosis and melanoma: molecular mechanisms. J Pathol 199, 275-288. DOI ScienceOn |
13 | Jin, Z. and El-Deiry, W. S. 2005. Overview of cell death signaling pathways. Cancer Biol Ther 4, 139-163. DOI ScienceOn |
14 | Abramson, N. and Melton, B. 2000. Leukocytosis: basics of clinical assessment. Am Fam Physician 62, 2053-2060. |
15 | Tada, A., Kanejwa, Y., Shoji, J. and Shibata, S. 1975. Studies on the saponins of the root of Platycodon grandiflorum A, De Can dolle. I. Isolation and the structure of platycodin D. Chem Pharm Bull (Tokyo) 23, 2965-2972. DOI ScienceOn |
16 |
Wang, C., Schuller Levis, G. B., Lee, E. B., Levis, W. R., Lee, D. W., Kim, B. S., Park, S. Y. and Park, E. 2004. Platycodin D and D3 isolated from the root of Platycodon grandiflorum modulate the production of nitric oxide and secretion of TNF- |
17 | Zhao, H. L., Cho, K. H., Ha, Y. W., Jeong, T. S., Lee, W. S. and Kim, Y. S. 2006. Cholesterol-lowering effect of platycodin D in hypercholesterolemic ICR mice. Eur J Pharmacol 537, 166-173. DOI ScienceOn |
18 | Ahn, K. S., Noh, E. J., Zhao, H. L., Jung, S. H., Kang, S. S. and Kim, Y. S. 2005. Inhibition of inducible nitric oxide synthase and cyclooxygenase II by Platycodon grandiflorum saponins via suppression of nuclear factor-kB activation in RAW 264.7 cells. Life Sci 76, 2315-2328. DOI ScienceOn |
19 | Lee, H., Kang, R., Kim, Y. S., Chung, S. I. and Yoon, Y. 2010. Platycodin D inhibits adipogenesis of 3T3 L1 cells by modulating kruppel like factor 2 and peroxisome proliferator activated receptor gamma. Phytother Res 24, 161-167. DOI ScienceOn |
20 | Lazebnik, Y. A., Kaufmann, S. H., Desnoyers, S., Poirier, G. G. and Earnshaw, W. C. 1994. Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE. Nature 371, 346-347. DOI ScienceOn |
21 | Meiler, J. and Schuler, M. 2006. Therapeutic targeting of apoptotic pathways in cancer. Curr Drug Targets 7, 1361-1369. DOI ScienceOn |
22 | Okada, H. and Mak, T. W. 2004. Pathways of apoptotic and non-apoptotic death in tumour cells. Nat Rev Cancer 4, 592-603. DOI ScienceOn |
23 | Salvesen, G. S. and Duckett, C. S. 2002. IAP proteins: blocking the road to death's door. Nat Rev Mol Cell Biol 3, 401-410. DOI ScienceOn |
![]() |