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http://dx.doi.org/10.5352/JLS.2013.23.3.383

Whitening Effect of Extracts and Fractions from Diospyros kaki calyx  

Hwang, Ju-Young (Korea Promotion Institute for Traditional Medicine Industry)
Park, Tae-Soon (Korea Promotion Institute for Traditional Medicine Industry)
Son, Jun-Ho (Korea Promotion Institute for Traditional Medicine Industry)
Publication Information
Journal of Life Science / v.23, no.3, 2013 , pp. 383-388 More about this Journal
Abstract
This study was performed to determine the whitening effect of several solvent fractions of Diospyros kaki extracts. Fractions from ethanol extracts of D. kaki were prepared by a systematic fractionation procedure using hexane, ethyl acetate, butanol, and $H_2O$. The ethyl acetate fractions were used to evaluate the inhibitory effects on tyrosinase activity and melanin synthesis in B16F10 melanoma cells. Ethyl acetate fractions suppressed the expression of tyrosinase, TRP-1 and TRP-2 in B16F10 melanoma cells. These results showed that ethyl acetate fractions of D. kaki could be developed as a skin whitening material in cosmetics.
Keywords
Diospyros kaki; tyrosinase; TRP-1; TRP-2; melanin;
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