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http://dx.doi.org/10.5352/JLS.2013.23.2.319

Various Aggregate Forms of Tryptophan Synthase α-Subunit  

Park, Myung Won (Department of Molecular Biology, College of Natural Sciences, Pusan National University)
Lim, Woon Ki (Department of Molecular Biology, College of Natural Sciences, Pusan National University)
Publication Information
Journal of Life Science / v.23, no.2, 2013 , pp. 319-323 More about this Journal
Abstract
Protein aggregation can cause diseases and hinder the production of useful recombinant proteins. The present study showed that at least three types of aggregates can be formed from tryptophan synthase ${\alpha}$-subunit (${\alpha}TS$) by varying conditions: (1) an opaque white precipitous aggregate, (2) a transparent gel-like precipitous aggregate, and (3) an unprecipitous aggregate. Macroscopically different aggregate types might suggest different mechanisms underlying aggregation processes.
Keywords
Opaque white aggregate; protein aggregate; transparent gel-like aggregate; tryptophan synthase ${\alpha}$-subunit; unprecipitous aggregate;
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