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http://dx.doi.org/10.5352/JLS.2013.23.12.1525

Evaluation of the Antioxidant Activity and Physiological Functionality of Baegilju  

Cho, Young Ho (Department of Pharmaceutics & Biotechnology, Konyang University)
Byun, Tae Kang (Department of Pharmaceutics & Biotechnology, Konyang University)
Lee, Jong-Hwa (Division of Research and Development, Korea Institute of Toxicology)
Lee, Gye Won (Department of Pharmaceutics & Biotechnology, Konyang University)
Publication Information
Journal of Life Science / v.23, no.12, 2013 , pp. 1525-1531 More about this Journal
Abstract
Baegilju is a famous traditional Korean wine made over the course of 100 days. The physiological functionalities of Baegilju were evaluated using different tests. The spectrophotometric method was used to determine the total concentration of polyphenolics and flavonoids and DPPH and ABTS radicals. A nitrite scavenging assay was used to evaluate antioxidant activity. The fibrin plate method was used for fibrinolysis and to evaluate angiotensin I converting enzyme (ACE) inhibitory activity; finally, the colorimetric determination method was used to evaluate acetylcholinesterase (AChE) inhibitory activity. The total polyphenolic content of non-sterilized Baegilju and sterilized Baegilju were 391.59 ${\mu}g$ and 401.33 ${\mu}g$ tannic acid equivalents/ml, respectively; and the flavonoids contents were 284.75 ${\mu}g$ and 308.35 ${\mu}g$ quercetin equivalents/ml, respectively. Baegilju exhibited more excellent antioxidant activities (DPPH and ABTS radicals, nitrite scavenging activity) than did Cheongju. In addition, the fibrinolytic activity and AChE inhibitory activity were found to be higher in Baegilju than they were in Cheongju. The ACE inhibitory activity of non-sterilized Baegilju, sterilized Baegilju, and Cheongju were 23.62%, 19.99%, and 38.91%, respectively. Therefore, these results suggest that Baegilju has potential as an antioxidant agent and anti-thrombosis agent.
Keywords
Acetylcholinesterase; angiotensin I converting enzyme; antioxidant activity; Baegilju fibrinolysis;
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1 Cooney, R. V. and Ross, P. D. 1987. N-Nitrosation and N-nitrosamine of morpholine by nitrogen dioxide in aqueous solution: Effects of vanillin and related phenols. J Agric Food Chem 35, 789-793.   DOI
2 Cushman, D. W. and Cheung, H. S. 1971. Spectrophotometric assay and properties of the angiotensin-converting enzyme of rabbit lung. Biochem Phamacol 20, 1637-1648.   DOI   ScienceOn
3 Cushman, D. W. and Ondetti, M. A. 1980. Inhibitors of angiotensin converting enzyme for treatment of hypertension. Biochem Pharmacol 29, 1871-1187.   DOI   ScienceOn
4 Ellman, G. L., Courtney, K. D., Andres, V. and Featherstne, R. M. 1961. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol 7, 68-75.
5 Follin, A. D. and Denis, W. 1915. A colorimetric method for the determination of phenols and phenol derivatives in urine. J Biol Chem 22, 305-308.
6 Harverkate, F. and Trass, D. W. 1974. Dose-response curves in the fibrin plate assay, Fibrinolytic activity of protease. Thromb Diath Haemost 32, 356-365.
7 Hayek, T., Fuhrman, B., Vaya, J., Rosenblat, M., Belinky, P., Coleman, R., Elis, A. and Aviram, M. 1997. Reduced progression of atherosclerosis in apoplipoprotein E-deficient mice following consumption of red wine, or its polyphenols quercetin or catechin is associated with reduced susceptibility of LDL to oxidation and aggregation. Arterioscler Thromb Vasc Biol 17, 2744-2752.   DOI   ScienceOn
8 Jeong, H. J., Park, S. B., Kim, S. and Kim, H. K. 2007. Total polyphenol content and antioxidative activity of wild grape (Vitis coignetiae) extracts depending on ethanol concentrations. J Korean Soc Food Sci Nutr 36, 1491-1496.   DOI   ScienceOn
9 Jun, Y. M., Ahn, Y. S. and Kim, M. H. 2006. The study on the cases of merchandising and suggestions for improving competitive power of traditional liquor. Korean J Comm Living Sci 17, 3-14.
10 Jung, Y. S., Park, S. J., Kim, J. E., Yang, S. A., Park, J. H., Kim, J. H., Jhee, K. H., Lee, S. P. and Lee, I. S. 2012. A comparative study of GABA, glutamate contents, acetylcholinesterase inhibition and antiradical activity of the methanolic extracts from 10 edible plants. Korean J Food Sci Technol 44, 447-451.   DOI   ScienceOn
11 Kato, H., Lee, I. E., Chuyen, N. V., Kim, S. B. and Hayase, F. 1987. Inhibition of nitrosamine formation by nondialyzable melanoidines. Agric Biol Chem 51, 1333-1338.   DOI
12 Kim, H. R. and Ahn, B. H. 2001. Research trend of Korean traditional alcoholic beverage. Food Ind Nutr 6, 5-10.
13 Kim, I. H., Park, W. S. and Koo, Y. J. 1996. Comparison of fermentation characteristics of Korean traditional alcoholic beverage with different in culture. Korean J Diet Culture 11, 339-348.
14 Kim, J. H., Lee, D. H., Jeong, S. C., Chung, K. S. and Lee, J. S. 2004. Characterization of antihypertensive angiotensin I-converting enzyme inhibitor from S. cerevisiae. J Microbiol Biotechnol 14, 1318-1323.
15 Arimoto-Kobayashi, S., Sugiyama, C., Harada, N., Takeuchi, M., Takemura, M. and Hayatsu, H. 1999. Inhibitory effects of beer and other alcoholic beverages on mutagenesis and DNA adduct formation induced by several carcinogens. J Agric Food Chem 47, 221-230.   DOI   ScienceOn
16 Blois, M. S. 1958. Antioxidant determination by the use of a stable free radical. Nature 181, 1199-1200.   DOI   ScienceOn
17 Cha, J. Y., Kim, S. Y., Jeong, S. J. and Cho, Y. S. 1999. Effects of hesperetin and naringenin on lipid concentration in oratic acid treated mice. J Life Sci 9, 389-394.
18 Kim, J. H., Lee, S. H., Kim, N. H., Choi, S. Y., Yoo, J. Y. and Lee, J. S. 2000. Manufacture and physiological functionality of Korean traditional liquors by using dandelion. Korean J Appl Microbiol Biotechnol 28, 367-371.
19 Choi, Y. M., Yu, K. W., Han, N. S., Koh, J. H. and Lee, J. S. 2006. Antioxidant activities and antioxidant compounds of commercial red wines. J Korean Soc Food Sci Nutr 35, 1286-1290.   DOI   ScienceOn
20 Clifford, A. J., Ebeler, S., Ebeler, J. D., Bills, N. D., Hinrichs, S. H., Teissedre, P. L. and Waterhouse, A. L. 1996. Delayed tumor onset in transgenic mice fed an amino acid-based diet supplemented with fed an amino acid-based diet supplemented with red wine solids. Am J Clin Nutr 64, 748-756.
21 Kim, J. S., Kwak, E. J. and Lee, Y. S. 2006. Effect on the quality characteristics of Korean traditional wines with the addition of rosemary (Rosmariuns officinalis L.). Korean J Food Cook Sci 22, 914-922.   과학기술학회마을
22 Kim, K. Y. and Lee, S. W. 1988. Analytical study on the cooking in 'On Zu Bub'. Korean J Diet Culture 3, 143-151.
23 Kim, S. M. and Lee, S. W. 1990. A study on the cooking in 'The Joobang'. Korean J Diet Culture 5, 415-423.
24 Koo, K. C., Lee, D. H., Kim, J. H., Yu, H. E., Park, J. S. and Lee, J. S. 2006. Production and characterization of antihypertensive angiotensin I-converting enzyme inhibitor from Pholiota adipose. J Microbiol Biotechnol 16, 757-763.
25 Lee, D. H., Kim, J. H., Kim, N. M. and Lee, J. S. 2002. Manufacture and physiological functionality of Korean traditional liquors by using chamomile (Matricaria chanmomile). Korean J Food Sci Technol 34, 109-113.
26 Moreno, M. I., Isla, M. I., Sampeiettro, A. R. and Vatuone, M. A. 2000. Comparison of the free radical-scavenging activity of propolis from several regions of Argentina. J Enthnopharmacol 71, 109-114.   DOI   ScienceOn
27 Lee, D. H., Kim, J. H., Park, J. S., Choi, Y. J. and Lee, J. S. 2004. Isolation and characterization of a novel angiotensin I-converting enzyme inhibitory peptide derived from the edible mushroom Tricholoma giganteum. Peptides 25, 621-627.   DOI   ScienceOn
28 Lee, D. H., Park, W. J., Lee, B. C., Lee, J. C., Lee, D. H. and Lee, J. S. 2005. Manufacture and physiological functionality of Korean traditional wine by using gugija (Lycii Fructus). Korean J Food Sci Technol 37, 789-794.
29 Miyagi, Y., Miwa, K. and Inoue, H. 1997. Inhibition of human low-density lipoprotein oxidation by flavonoids in red wine and grape juice. Am J Cardiol 80, 1627-1631.   DOI   ScienceOn
30 Pace-Asicak, C. R., Hahn, S., Diamandis, E. P., Soleas, G. and Goldberg, D. M. 1995. The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: Implications for protection against coronary heart disease. Clin Chim Acta 235, 207-219.   DOI   ScienceOn
31 Re, R., Pellegrini, N., Proteggente, A., Pannala, A., Yang, M. and Rice-Evans, C. 1999. Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radical Bio Med 26, 1231-1237.   DOI   ScienceOn
32 Rhyu, M. R., Nam, Y. J. and Lee, H. Y. 1996. Screening of angiotensin I-converting enzyme inhibitors in cereals and legumes. J Biotechnol 5, 334-337.
33 Vincenzo, N. T. 2001. Acetylcholinesterase in Alzheimer's disease. Mech Ageing Dev 122, 1961-1969.   DOI   ScienceOn
34 Saito, Y., Nakamura, K., Kawato, A. and Imayasu, S. 1994. Structure and activity of angiotensin I converting enzyme inhibitory peptides from sake and sake less. Biosci Biotech Biochem 58, 1767-1771.   DOI   ScienceOn
35 Seo, S. B., Kim, J. H., Kim, N. M., Choi, S. Y. and Lee, J. S. 2002. Effect of acasia (Robinia pseudo-acasia) flower on the physiological functionality of Korean traditional rice wine. Korean J Microbiol Biotechnol 30, 410-414.
36 Stoewsand, G. S., Anderson, J. and Munson, L. 1991. Inhibition by wine of tumorigenesis induced by ethyl carbamate (urethane) in mice. Food Chem Toxicol 29, 291-295.   DOI   ScienceOn
37 Yu, H. E., Lee, D. H., Lee, J. H., Choi, S. Y. and Lee, J. S. 2005. Quality characteristics and cardiovascular activities of Korean traditional wines and liquors. Food Sci Biotechnol 14, 772-777.
38 Yun, Y. P., Kang, W. S. and Lee, M. Y. 1996. The antithrombotic effects of green tea catechins. J Food Hyg Safe 11, 77-82.