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http://dx.doi.org/10.5352/JLS.2012.22.9.1261

Effect of Aerobic Exercise and Gym-ball Exercise on the Liver Function Test Index, Adipokines, and Cardiovascular Risk Factors in Obese Children with Nonalcoholic Fatty Liver Disease  

Lee, Sung-Soo (Department of Coaching, Collage of Sports Sciences, Dong-A University)
Publication Information
Journal of Life Science / v.22, no.9, 2012 , pp. 1261-1267 More about this Journal
Abstract
The aim of the present study was to investigate effects of a 12-week aerobic exercise training program and a gym-ball exercise training program on body composition, aspartate aminotransferase (AST), alanine aminotransferase (ALT), adipokines, and cardiovascular risk factors in obese children with nonalcoholic fatty liver disease. The subjects were separated into two groups, an aerobic exercise group (n=10), which practiced moderate aerobic exercise training for 12 weeks, and a gym-ball exercise group (n=13), which practiced resistance exercise training for 12 weeks. The results of the analyses are as follows: Weight, body mass index, and body fat were significantly lower (p<0.01, respectively), whereas the $VO_2$ max was higher in both groups (p<0.01). Fasting glucose, insulin and HOMA-IR levels were significantly decreased in the gym-ball exercise group (p<0.05), whereas adiponectin, AST, and ALT levels were significantly increased (p<0.05, p<0.001, p<0.001, respectively) in both groups after the 12-week exercise training program. In addition, our results showed that HOMA-IR, insulin, and concentrations of C-reactive protein (CRP) were significantly lower in both groups. They demonstrate that a 12-week program of regular aerobic exercise or gym-ball exercise yields beneficial effects such as an amelioration of cardiovascular risk factors, body indices, and liver function in obese children with nonalcoholic fatty liver disease.
Keywords
Adiponectin; aspartate aminotransferase (AST); alanine aminotransferase (ALT); C-Reactive Protein (CRP); homeostasis model assessment of insulin resistance (HOMA-IR);
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1 Benson, A. C., Torode, M. E. and Fiatarone Singh, M. A. 2008. The effect of high-intensity progressive resistance training on adiposity in children: a randomized controlled trial. Int. J. Obes.(Lond). 32, 1016-1027.   DOI
2 Clark, J. M., Brancati, F. L. and Diehl, A. M. 2003. The prevalence and etiology of elevated aminotransferase levels in the United States. Am. J. Gastroenterol. 98, 960-967.   DOI   ScienceOn
3 Clark, J. M., Brancati, F. L. and Diehl, A. M. 2002. Nonalcoholic fatty liver disease. Gastroenterology 122, 1649-1657.   DOI   ScienceOn
4 Eisenmann, J. C., Baetee, R. T., Smith, D. T., Welk, G. J. and Fu, Q. 2008. Combined influence of physical activity and television viewing on the risk of overweight in US youth. Int. J. Obes. 32, 613-618.   DOI
5 Fantuzzi, G. 2005. Adipose tissue, adipokines, and inflammation. J. Allergy Clin. Immunol. 115, 911-919.   DOI   ScienceOn
6 Hotamisligil, G. S., Arner, P., Caro, J. F., Atkinson, R. L. and Spiegelman, B. M. 1995. Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. J. Clin. Invest. 95, 2409-2415.   DOI   ScienceOn
7 Hui, J. M., Hodg, A., Farrell, G. C., Kench, J. G., Kriketos, A. and Geroge, J. 2004. Beyond insulin resistance in NASH: TNF-alpha or adiponectin? Hepatology 40, 46-54.
8 Laurson, K., Eisenmann, J. C. and Moore, S. 2008. Lack of association between television viewing, soft drink, physical activity and body mass index in children. Acta. Paediatr. 97, 795-800.   DOI
9 Ludwig, J., Viggiano, T. R., McGill, D. B. and Oh, B. J. 1980. Nonalcoholic steatohepatitis : Mayo Clinic experiences with a hitherto unnamed disease. Mayo. Clin. Proc. 55, 434-438.
10 Mathur, P., Das, M. K. and Arora, N. K. 2007. Non-alcoholic fatty liver disease and childhood obesity. Indian J. Pediatr. 74, 401-407.   DOI
11 Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F. and Turner, R. C. 1985. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetology 28, 412-419.   DOI   ScienceOn
12 Nam, S. N. and An, S. H. 2008. The effect of combination exercise on body composition blood cholesterol and cardiac risk factors in middle obesity man. Korean Society of Exer. Physiol. 17, 49-58.   과학기술학회마을
13 Neuschwander-Tetri, B. A. and Caldwell, S. H. 2003. Nonalcoholic steatohepatitis : summary of an AASLD Single Topic Conference. Hepatology 37, 1202-1219.   DOI   ScienceOn
14 Nobili, V., Marcellini, M., Devito, R., Ciampalini, P., Piemonte, F., Comparcola, D., Sartorelli, M. R. and Angulo, P. 2006. NAFLD in children: a prospective clinical-pathological study and effect of lifestyle advice. Hepatology 44, 458-465.   DOI   ScienceOn
15 Obisesan, T. O., Ferrell, R. E., Goldberg, A. P., Phares, D. A., Ellis, T. J. and Hagberg, J. M. 2008. APOE genotype affects black-white responses of high-density lipoprotein cholesterol subspecies to Aerobic exercise training. Metabolism 57, 1669-1676   DOI
16 Parti, D., Tailoi, E. and Zanella, A. 2002. Updated definitions of healthy ranges for serum alanine aminotransferase levels. Ann. Intern. Med. 137, 1-10.   DOI
17 Rashid, M. and Roberts, E. A. 2000. Nonalcoholic steatohepatitis in children. J. Pediatr. Gastroenterol. Nutr. 30, 48-53.   DOI
18 Sanyal, A. J. 2002. American Gastroenterological Association. AGA technical review on nonalcoholic fatty liver disease. Gastroenterology 123, 1705-1725.   DOI   ScienceOn
19 Schindhelm, R. K., Dekker, J. M. and Nijpels, G. 2007. Alanine aminotransferase predict coronary heart disease events: a 10-year follow-up of the Hoorn study. Atherosclerosis 191, 391-396.   DOI   ScienceOn
20 Savoye, M., Shaw, M., Dziura, J., Tamborlane, W. V., Rose, P., Guandalini, C., Goldberg-Gell, R., Burgert, T. S., Cali, A. M., Weiss, R. and Caprio, S. 2007. Effects of a weight management program on body Composition and metabolic parameters in overweight children : a randomized controlled trial. JAMA. 297, 697-704.   DOI
21 Tragher, G. and Arcaro, G. 2007. Nonalcoholic fatty liver disease and increased risk of cardiovascular disease. Atherosclerosis 191, 235-240.   DOI
22 Tragher, G., Bertolini, L. and Poli, F. 2005. Nonalcoholic fatty liver disease and risk of future cardiovascular event among type 2 diabetic patients. Diabetes 54, 3541-3546.   DOI
23 Trayhurn, P. and Wood, I. S. 2004. Adipokines: inflammation and the pleiotropic role of white adipose tissue. Br. J. Nutr. 92, 347-355.   DOI   ScienceOn
24 Vettor, R., Milan, G., Rossato, M. and Federspil, G. 2005. Review article: adipocytokines and insulin resistance. Aliment. Pharmacol. Ther. 22, 3-10.   DOI
25 Yang, H. R., Ko, J. S. and Seo, J. K. 2007. The Role of Adipokines in the Pathogenesis of Non-alcoholic Fatty Liver Disease in Obese Children: the Relationship between Body Fat Distribution and Insulin Resistance. Pediatric Gastroenterology, Hepatol. Nutr. 10, 185-192.
26 Angulo, P. 2002. Nonalcoholic fatty liver disease. N. Engl. J. Med. 346, 1221-1231.   DOI