Modulatory Effects of Korean Red Ginseng Extract (Panax ginseng C.A. Meyer) on Cytochrome P450 after Oral Administration to Mice for 14 Days
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Kim, Hee-Yeon
(College of Pharmacy, Kyungpook National University)
Nam, Woong-Shik (College of Pharmacy, Kyungpook National University) Kim, Seong-Hee (College of Pharmacy, Kyungpook National University) Jang, Hye-Ryang (College of Pharmacy, Kyungpook National University) Lee, Mi-Kyoung (College of Pharmacy, Kyungpook National University) Kim, Tae-Wan (Department of Physiology, College of Veterinary Medicine, Kyungpook National University) Lee, Sang-Kyu (College of Pharmacy, Kyungpook National University) |
1 | Boyne, A. F. and Ellman, G. L. 1972. A methodology for analysis of tissue sulfhydryl components. Anal. Biochem. 46, 639-653. DOI ScienceOn |
2 | Chang, T. K., Chen, J. and Benetton, S. A. 2002. In vitro effect of standardized ginseng extracts and individual ginsenosides on the catalytic activity of human CYP1A1, CYP1A2, and CYP1B1. Drug Metab. Dispos. 30, 378-384. DOI |
3 | Ha, K. C., Kim, M. G., Oh, M. R., Choi, E. K., Back, H. I., Kim, S. Y., Park, E. O., Kwon, D. Y., Yang, H. J., Kim, M. J., Kang, H. J., Lee, J. H., Choi, K. M., Chae, S. W. and Lee, C. S. 2012. A placebo-controlled trial of Korean red ginseng extracts for preventing Influenza-like illness in healthy adults. BMC Complement Altern. Med. 12, 10. DOI |
4 | Han, M. and Fang, X. L. 2006. Difference in oral absorption of ginsenoside Rg1 between in vitro and in vivo models. Acta Pharmacol. Sin. 27, 499-505. DOI |
5 | Hao, M., Ba, Q., Yin, J., Li, J., Zhao, Y. and Wang, H. 2011. Deglycosylated ginsenosides are more potent inducers of CYP1A1, CYP1A2 and CYP3A expression in HepG2 cells than glycosylated ginsenosides. Drug. Metab. Pharmacokinet. 26, 201-205. DOI |
6 | Henderson, G. L., Harkey, M. R., Gershwin, M. E., Hackman, R. M., Stern, J. S. and Stresser, D. M. 1999. Effects of ginseng components on c-DNA-expressed cytochrome P450 enzyme catalytic activity. Life Sci. 65, 209-214. |
7 | Kim, H., Lee, S. G., Chae, I. G., Kim, M. J., Im, N. K., Yu, M. H., Lee, E. J. and Lee, I. S. 2011. Antioxidant effects of fermented red ginseng extracts in streptozotocin-induced diabetic rats. Ginseng 35, 129-137. DOI ScienceOn |
8 | Kim, S. N., Ha, Y. W., Shin, H., Son, S. H., Wu, S. J. and Kim, Y. S. 2007. Simultaneous quantification of 14 ginsenosides in Panax ginseng C.A. Meyer (Korean red ginseng) by HPLC-ELSD and its application to quality control. J. Pharm. Biomed. Anal. 45, 164-170. DOI ScienceOn |
9 | Lee, M. H., Lee, B. H., Jung, J. Y., Cheon, D. S., Kim, K. T. and Choi, C. 2011. Antiviral effect of Korean red ginseng extracts and ginsenosides on murine norovirus and feline calicivirus as surrogates for human norovirus. Ginseng 35, 429-435. DOI ScienceOn |
10 | Liu, Y., Wang, Q., Yao, X. and Li, Y. 2010. Induction of CYP3A and MDR1 gene expression by baicalin, baicalein, chlorogenic acid, and ginsenoside Rf through constitutive androstane receptor- and pregnane X receptor-mediated pathways. Eur. J. Pharmacol. 640, 46-54. DOI |
11 | Lowry, O. H., Rosebrough, N. J., Farr, A. L. and Randall, R. J. 1951. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193, 265-275. |
12 | Markowitz, J. S., Donovan, J. L., DeVane, C. L., Taylor, R. M., Ruan, Y., Wang, J. S. and Chavin, K. D. 2003. Effect of St John's wort on drug metabolism by induction of cytochrome P450 3A4 enzyme. JAMA 290, 1500-1504. DOI |
13 | Ohkawa, H., Ohishi, N. and Yagi, K. 1979. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 95, 351-358. DOI ScienceOn |
14 | Sohn, E. H, Jang, S. A., Lee, C. H., Jang, K. H., Kang, S. C., Park, H. J. and Pyo, S. 2011. Effects of Korean red ginseng extracts for the treatment of atopic dermatitis-like skin lesions in mice. Ginseng 35, 479-486. DOI ScienceOn |
15 | Song, Y. B., An, Y. R., Kim, S. J., Park, H. W., Jung, J. W., Kyung, J. S., Hwang, S. Y. and Kim, Y. S. 2012 Lipid metabolic effect of Korean red ginseng extracts in mice fed on a high-fat diet. J. Sci. Food. Agric. 92, 388-396. DOI ScienceOn |
16 | Xu, Q. F., Fang, X. L. and Chen, D. F. 2003. Pharmacokinetics and bioavailability of ginsenoside Rb1 and Rg1 from Panax notoginseng in rats. J. Ethnopharmacol. 84, 187-192. DOI ScienceOn |
17 | Sumiyoshi, M., Sakanaka, M. and Kimura, Y. 2010. Effects of Red Ginseng extracts on allergic reactions to food in Balb/c mice. J. Ethnopharmacol. 132, 206-212. DOI |
18 | Wang, W., Wang, G. J., Xie, H. T., Sun, J. G., Zhao, S., Jiang, X. L., Li, H., Lv, H., Xu, M. J. and Wang, R. 2007. Determination of ginsenoside Rd in dog plasma by liquid chromatography-mass spectrometry after solid-phase extractsion and its application in dog pharmacokinetics studies. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 852, 8-14. DOI |
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