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http://dx.doi.org/10.5352/JLS.2012.22.8.1132

Regulation of Endoplasmic Reticulum Stress Response by the Immobilization Stress  

Kwon, Ki-Sang (Departments of Anatomy, School of Medicine, Chungnam National University,)
Kwon, Young-Sook (Department of Emergency Medicine, Chungnam National University Hospital)
Kim, Seung-Whan (Department of Nursing, Joongbu University)
Kim, Dong-Woon (Departments of Anatomy, School of Medicine, Chungnam National University,)
Kwon, O-Yu (Departments of Anatomy, School of Medicine, Chungnam National University,)
Publication Information
Journal of Life Science / v.22, no.8, 2012 , pp. 1132-1136 More about this Journal
Abstract
Many kind of cell stresses induce gene expression of unfolded protein response (UPR)-associated factors. This study demonstrated that up- and down-regulation of gene expression of endoplasmic reticulum (ER) stress chaperones and ER stress sensors was induced by immobilization stress in the rat organs (adrenal gland, liver, lung, muscle). However, no statistically significant regulation was detected in the others (heart, spleen, thymus, kidney, testis). The results are the first to show that immobilization stress induces UPR associated gene expression, will help to explain immobilization stress-associated ER stress.
Keywords
Immobilization stress; endoplasmic reticulum (ER) stress; ER chaperone; ER stress sensor;
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