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http://dx.doi.org/10.5352/JLS.2012.22.8.1126

Effect of Trans-unsaturated Fatty Acid on Serum Lipid Levels in Mice  

Yu, Sun-Nyoung (Department of Microbiology and Immunology, Pusan National University School of Medicine)
Ahn, Jeong-Bin (School of Nano-Bioscience and Chemical Engineering, Ulsan National Institute of Science and Technology)
Park, Eun-Young (Department of Chemical Engineering, College of Engineering, Pukyong University)
Lee, Sun-Jung (Department of Health Care Management, Catholic University of Pusan)
Tak, Min-Gi (Department of Genetic Engineering, College of Biotechnology and Bioengineering, Sunkyunkwan University)
Kim, Kwang-Youn (Department of Microbiology and Immunology, Pusan National University School of Medicine)
Kim, Sang-Hun (Department of Microbiology and Immunology, Pusan National University School of Medicine)
Kim, Ki-Dae (DongNae Girls' High School)
Ahn, Soon-Cheol (Department of Microbiology and Immunology, Pusan National University School of Medicine)
Publication Information
Journal of Life Science / v.22, no.8, 2012 , pp. 1126-1131 More about this Journal
Abstract
The purpose of this study was to investigate the effects of trans-unsaturated fatty acid (TFA), saturated fatty acid (SFA) and general unsaturated fatty acid (USFA) on serum lipid levels in ICR mice. Male ICR 8-week-old mice were divided into six groups; the control group (C) fed with normal diet, the TFA-1 group fed with 10% trans-unsaturated fatty acid, the TFA-2 group fed with 30% trans-unsaturated fatty acid, the TFA-3 group fed with 50% trans-unsaturated fatty acid, the SFA group fed with 50% saturated fatty acid, and USFA group fed with 50% general unsaturated fatty acid. The serum total cholesterol of TFA-3 and SFA was higher than those of other fat groups and C. The serum triglyceride (TG) of TFA-3 and SFA showed the highest levels among all of diet groups. Also the serum HDL cholesterol levels of TFA-3 showed the lowest. LDL cholesterol and atherogenic indices (AI) were remarkedly increased in TFA-3 and SFA, as compared with other fat fed groups and C. Taken together with results, the TFA-3 group showed serum lipid levels similar to the SFA and different from the USFA. These results suggest that intake of high level of trans-unsaturated fatty acid increased serum triglyceride, LDL cholesterol and atherogenic indices, which may affect risk on serum lipid level for lipid metabolism syndrome.
Keywords
Trans-unsaturated fatty acid; saturated fatty acid; general unsaturated fatty acid; serum lipid level; atherogenic indices;
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