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http://dx.doi.org/10.5352/JLS.2012.22.8.1092

Anti-wrinkle Compounds Isolated from the Seeds of Arctium lappa L.  

Hwang, Ju-Young (Korea Promotion Institute for Traditional Medicine Industry)
Park, Tae-Soon (Korea Promotion Institute for Traditional Medicine Industry)
Kim, Dong-Hee (Korea Promotion Institute for Traditional Medicine Industry)
Hwang, Eun-Young (Korea Promotion Institute for Traditional Medicine Industry)
Lee, Jung-Noh (Coreana Cosmetics Co. Ltd. Songpa R&D Center)
Lee, Ji-Young (Coreana Cosmetics Co. Ltd. Songpa R&D Center)
Lee, Ghang-Tai (Coreana Cosmetics Co. Ltd. Songpa R&D Center)
Lee, Kun-Kook (Coreana Cosmetics Co. Ltd. Songpa R&D Center)
Son, Jun-Ho (Korea Promotion Institute for Traditional Medicine Industry)
Publication Information
Journal of Life Science / v.22, no.8, 2012 , pp. 1092-1098 More about this Journal
Abstract
This study was carried out to discover the skin wrinkle reducing components in the seeds of Arctium lappa. The isolation of a methylene chloride-soluble fraction of 70% ethanol extract from the seeds of Arctium lappa using a procollagen type-1 synthesis and MMP-1 activity resulted in the isolation and identification of four lignin compounds: arctiin, arctigenin, matairesinol, and diarctigenin. All structures were confirmed via NMR and MS spectroscopic data. To determine cell viability and procollagen type-1 synthesis, human dermal fibroblasts were treated with 10-100 ${\mu}M$. As a result, none of the four compounds showed cytotoxicity up to 50 ${\mu}M$. We also investigated their procollagen type-1 synthesis and MMP-1 inhibition activity and found that arctiin had the highest activity in terms of both procollagen synthesis and MMP-1 inhibition among all four compounds. Putting all the data together, we suggest that arctiin be used in cosmetics as an anti-wrinkle material.
Keywords
Arctium lappa; arctiin; procollagen type-1 synthesis; matrix metalloproteinase (MMP) inhibition activity;
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