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http://dx.doi.org/10.5352/JLS.2012.22.7.958

Effect of Artemisia capillaris Extracts on Antioxidant Activity and Allergic Dermatitis  

Kim, Jong-Myeung (Department of Applied Biology, Kyungpook National University)
Shin, Yong-Kyu (Research Institute of Biotechnology, Bion Co., Ltd.)
Kim, Byung-Oh (Department of Applied Biology, Kyungpook National University)
Kim, Jong-Kuk (Department of Life Science, Kyungpook National University)
Lee, Sang-Han (Food & Bio-Industry Research Institute, and Department of Food Science & Biotechnology, Kyungpook National University)
Kim, Young-Sup (Department of Applied Biology, Kyungpook National University)
Publication Information
Journal of Life Science / v.22, no.7, 2012 , pp. 958-963 More about this Journal
Abstract
The antioxidant activities of 6 solvent extracts of Artemisia capillaris were evaluated in a dintroflurobenzen (DNFB)-induced allergic mouse model. In vitro antioxidant activities were determined using DPPH and the FRAP test. Methanol (DPPH: 85.87%, FRAP: 1.772) and $dH_2O$ (DPPH: 60.69%, FRAP: 3.185) extracts showed the highest antioxidant activities compared with other solvents (ethyl acetate 41.81%, 0.407, hexane 8.37%, 0.328, etc.). In addition, we tested atopic dermatitis (AD)-like skin lesions in mice treated with DNFB. The methanol extract of A. capillaris on the AD-like skin lesions in DNFB-induced atopy inhibited ear thickness increases (47%) and the skin lesions (45%) compared with a positive control (methanol). The results suggest that they have potential as natural antioxidants and allergy-improving substances and that they may be valuable materials in the functional food or cosmeceutical industry.
Keywords
Artemisia capillaris; antioxidant; allergy; dintroflurobenzen (DNFB);
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