Browse > Article
http://dx.doi.org/10.5352/JLS.2012.22.6.852

In vivo Anti-inflammatory, Antipyretic, and Analgesic Activities of the Aquaculturable Green Seaweed Codium fragile Extracts in Mice  

Kang, Ji-Young (Department of Biotechnology, Pukyong National University)
Luyen, Quoc-Hai (Department of Biotechnology, Pukyong National University)
Khan, Mohammed Nurul Absar (Department of Biotechnology, Pukyong National University)
Choi, Jae-Suk (RIS Center, IACF, Silla University)
Choi, In-Soon (RIS Center, IACF, Silla University)
Hong, Yong-Ki (Department of Biotechnology, Pukyong National University)
Publication Information
Journal of Life Science / v.22, no.6, 2012 , pp. 852-856 More about this Journal
Abstract
Dichloromethane, ethanol, and boiling water extracts of the green seaweed Codium fragile, used as an herbal medicine and known as an invasive species over the world, were examined for anti-inflammatory, antipyretic, and analgesic activities in mice. The dichloromethane and ethanol extracts inhibited inflammatory symptoms of mouse ear edema and erythema by 74% or higher. The extracts also demonstrated inhibition of pyrexia, similar to that of acetyl salicylic acid. Eicosapentaenoic acid was isolated from the seaweed as the main active anti-inflammatory compound. These findings are consistent with various claims that the seaweed can be used as remedies for inflammation-related symptoms.
Keywords
Codium fragile; anti-inflammation; eicosapentaenoic acid; indigenous medicine; green seaweed;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Curtis, C. L., Hughes, C. E., Flannery, C. R., Little, C. B., Harwood, J. L. and Caterson, B. 2000. n-3 Fatty acids specifically modulate catabolic factors involved in articular cartilage degradation. J. Biol. Chem. 275, 721-724.   DOI
2 Danno, K., Ikai, K. and Imamura, S. 1993. Anti-inflammatory effects of eicosapentanoic acid on experimental skin inflammation models. Arch. Dermatol. Res. 285, 43-45.
3 Donguibogam Committee. 1999. Translated Donguibogam. pp. 1911-1912, Bubinmunwha Press, Seoul.
4 Fu, M., Koulman, A., van Rijssel, M., Lutzen, A., de Boer, M. K., Tyl, M. R. and Liebezeit, G. 2004. Chemical characterization of three haemolytic compounds from the microalgal species Fibrocapsa japonica (Raphidophyceae). Toxicon 43, 355-363.   DOI
5 Gray, W. D., Osterberg, A. C. and Scute, J. T. 1970. Measurement of the analgesic efficacy and potency of pentazocine by the D'Amour and Smith method. J. Pharmacol. Exp. Ther. 172, 154-162.
6 Griswold, D. E., Martin, L. D., Badger, A. M., Breton, J. and Chabot-Fletcher, M. 1998. Evaluation of the cutaneous anti- inflammatory activity of azaspiranes. Inflamm. Res. 47, 56-61.
7 Ishihara, K., Komatsu, W., Saito, H. and Shinohara, K. 2002. Comparison of the effects of dietary alpha-linolenic, stearidonic and eicosapentanoic acids on production of inflammatory mediators in mice. Lipids 37, 481-486.   DOI
8 James, M. J., Gibson, R. A. and Cleland, L. G. 2000. Dietary polyunsaturated fatty acids and inflammatory mediator production. Am. J. Clin. Nutr. 71, 343-348.
9 Kang, C. H., Choi, Y. H., Park, S. Y. and Kim, G. Y. 2012. Anti-inflammatory effects of methanol extract of Codium fragile in lipopolysaccharide-stimulated RAW 264.7 cells. J. Med. Food. 15, 44-50.   DOI   ScienceOn
10 Kang, J. W. 1968. Illustrated Encyclopedia of Fauna & Flora of Korea: Marine Algae. pp. 85-90, Samhwa Press, Seoul.
11 Khan, M. N. A., Cho, J. Y., Lee, M. C., Kang, J. Y., Park, N. G., Fujii, H. and Hong, Y. K. 2007. Isolation of two anti- inflammatory and one pro-inflammatory polyunsaturated fatty acids from the brown seaweed Undaria pinnatifida. J. Agric. Food Chem. 55, 6984-6988.   DOI   ScienceOn
12 Lee, M. C., Konishi, N. and Fujii, H. 2003. Blood flow analysis of skin tissue under the sacrum using laser speckle flowgraphy. Optic Rev. 10, 562-566.   DOI   ScienceOn
13 Khan, M. N. A., Lee, M. C., Kang, J. Y., Park, N. G., Fujii, H. and Hong, Y. K. 2008. Effects of the brown seaweed Undaria pinnatifida on erythematous inflammation assessed using digital photo analysis. Phytother. Res. 22, 634-639.   DOI   ScienceOn
14 Kim, H. H., Shin, C. M., Park, C. H., Kim, K. H., Cho, K. H., Eun, H. C. and Chung, J. H. 2005. Eicosapentaenoic acid inhibits UV-induced MMP-1 expression in human dermal fibroblasts. J. Lipid Res. 46, 1712-1720.   DOI   ScienceOn
15 Korea Fisheries Association. 2010. Korean Fisheries Yearbook. pp. 362-364, Samshin Press, Seoul.
16 Sethi, S. 2002. Inhibition of leukocyte-endothelial interactions by oxidation omega-3 fatty acids: a novel mechanism for the anti-inflammatory effects of omega-3 fatty acids in fish oil. Redox Rep. 7, 369-378.   DOI
17 Smit, A. J. 2004. Medicinal and pharmaceutical uses of seaweed natural products: a review. J. Appl. Phycol. 16, 245-262.   DOI   ScienceOn
18 Teotino, U. M., Friz, L. P., Gandini, A. and Bella, D. D. 1963. Thio derivatives of 2,3-dihydro-4H-1,3-benzoazin-4-one synthesis and pharmacological properties. J. Med. Chem. 6, 248-250.   DOI
19 Tseng, C. K. and Chang, C. F. 1984. Chinese seaweeds in herbal medicine. Hydrobiologia 116/117, 152-154.   DOI
20 Watanabe, S., Metaxas, A. and Scheibling, R. E. 2009. Dispersal potential of the invasive green alga Codium fragile ssp. fragile. J. Exp. Mar. Biol. Ecol. 381, 114-125.   DOI
21 WHO. 1992. Research Guidelines for Evaluating the Safety and Efficacy of Herbal Medicine. pp. 1-38, Regional Office for Western Pacific, Manila.