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http://dx.doi.org/10.5352/JLS.2012.22.5.634

LP9M80-H Isolated from Liriope platyphylla Could Help Alleviate Diabetic Symptoms via the Regulation of Glucose and Lipid Concentration  

Kim, Ji-Eun (Department of Biomaterials Science, College of Natural Resources & Life Science, Pusan National University)
Hwang, In-Sik (Department of Biomaterials Science, College of Natural Resources & Life Science, Pusan National University)
Goo, Jun-Seo (Department of Biomaterials Science, College of Natural Resources & Life Science, Pusan National University)
Nam, So-Hee (Department of Biomaterials Science, College of Natural Resources & Life Science, Pusan National University)
Choi, Sun-Il (Department of Biomaterials Science, College of Natural Resources & Life Science, Pusan National University)
Lee, Hae-Ryun (Department of Biomaterials Science, College of Natural Resources & Life Science, Pusan National University)
Lee, Young-Ju (Department of Biomaterials Science, College of Natural Resources & Life Science, Pusan National University)
Kim, Yoon-Han (Department of Horticultural Bioscience, College of Natural Resources & Life Science, Pusan National University)
Park, Se-Jin (Department of Horticultural Bioscience, College of Natural Resources & Life Science, Pusan National University)
Kim, Nahm-Su (Technology Cooperation Bureau, Rural Development Administration)
Choi, Young-Hwan (Department of Horticultural Bioscience, College of Natural Resources & Life Science, Pusan National University)
Hwang, Dae-Youn (Department of Biomaterials Science, College of Natural Resources & Life Science, Pusan National University)
Publication Information
Journal of Life Science / v.22, no.5, 2012 , pp. 634-641 More about this Journal
Abstract
It was reported that the novel compounds (LP9M80-H) of $Liriope$ $platyphylla$ regulate glucose transporter (Glut) biosynthesis by activating the insulin-signaling pathway in the liver and brain of ICR mice. To investigate the therapeutic effects of LP9M80-H on the pathology of diabetes and obesity, alterations of key factors related to symptoms were analyzed in the Otsuka Long Evans Tokushima Fatty (OLETF) rats treated with LP9M80-H for 2 weeks. The abdominal fat masses in the LP9M80-H-treated group were lower than the vehicle-treated group, although there was no difference in body weight between the two groups. Additionally, when compared to the vehicle-treated group, LP9M80-H treatment induced a significant decrease in glucose levels and an increase in the insulin concentration in the blood of OLETF rats. A high level of insulin protein was also detected in pancreatic ${\beta}$ cells of LP9M80-H-treated OLETF rats. A significant reduction in the concentration of lipids and adiponectin was detected only in LP9M80-H-treated OLETF rats. Furthermore, the expression of insulin receptor ${\beta}$ and the insulin receptor substrate (IRS) was dramatically decreased in LP9M80-H-treated OLETF rats compared to the vehicle-treated group. Of the glucose transporters located downstream of the insulin-signaling pathway, glucose transporters (Glut) -2 and -3 were significantly decreased in LP9M80-H-treated OLETF rats, while the level of Glut-4 was maintained under all conditions. Therefore, these results suggest that LP9M80-H may contribute to relieving symptoms of diabetes and obesity through glucose homeostasis and regulation of lipid concentration.
Keywords
Liriope platyphylla; diabetes; fat; OLETF rat;
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Times Cited By KSCI : 3  (Citation Analysis)
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