Browse > Article
http://dx.doi.org/10.5352/JLS.2012.22.5.569

The Effects of Exercise on Neurotrophins, Hepatocyte Growth Factor (HGF), and Oxidative Stress in Obese Children  

Woo, Jin-Hee (Department of Physical Education, College of Sports Science, Dong-A University)
Publication Information
Journal of Life Science / v.22, no.5, 2012 , pp. 569-574 More about this Journal
Abstract
This study was conducted to investigate the effect of exercise on oxidative stress, nerve growth, and hepatocyte growth factors in obese children. After 12 weeks of aerobic exercise training, the aforementioned parameters before and after the training were compared. As a result, the nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) were shown to be lower in the OT than in the NT before and after the training, respectively ($p$ <0.05). The NGF was shown to have increased in both groups after the training ($p$ <0.05). The hepatocyte growth factor (HGF) was shown to be higher in the OT than in the NT before the training ($p$ <0.05), with no difference found afterwards. The malondialdehyde (MDA), ox-LDL, and 8-OHdG (Oxo-2'-deoxyguanosine) were shown to be higher in the OT than in the NT ($p$ <0.05). For ox-LDL, a difference was found between before and after the training ($p$ <0.05). The results of this study showed that obesity induced oxidative stress and caused the abnormalities of nerve and HGF secretion in obese children, and that the 12 weeks of aerobic exercise increased NGF levels, thereby promoting the development of neurogenesis in children.
Keywords
Exercise training; neurotrophins; hepatocyte growth factor; oxidative stress; obese children;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Aguiar, Jr. A. S., Castro, A. A., Moreira, E. L., Glaser, V., Santos, A. R. S., Tasca, C. I., Latini, A. and Prediger, R. D. S. 2011. Short bout of mild-intensity physical exercise improve spatial learning and memory in aging rats: Involvement of hippocampal plasticity via AKT, CREB and BDNF signaling. Mech. Ageing Devel. 32, 560-567.
2 Bullo, M., Peeraully, M. R., Trayhurn. P., Folch, J. and Salas-Salvadó, J. 2007. Circulating nerve growth factor levels in relation to obesity and the metabolic syndrome in women. Eur. J. Endocrinol. 157, 303-310.   DOI
3 Chen, L., Liu, L., Luo, Y. and Huang, S. 2008. MAPK and mTOR pathways are involved in cadmium-induced neuronal apoptosis. J. Neurochem. 105, 251-261.   DOI   ScienceOn
4 Cotman, C. and Engesser-Cesar, C. 2002. Exercise enhances and protects brain function. Exerc. Sport Sci. Rev. 30, 75-79.   DOI   ScienceOn
5 Einarsdottir, E., Carlsson, A., Minde, J., Toolanen, G., Svensson, O., Solders, G., Holmgren, G., Holmberg, D. and Holmberg, M. 2004. A mutation in the nerve growth factor beta gene(NGFB) causes loss of pain perception. Human Mole. Gen. 13, 799-805.   DOI
6 Esterbauer, H., Wäg, G. and Puhl, H. 1993. Lipid peroxidation and its role in atherosclerosis. Br. Med. Bull. 49, 566-576.
7 Furukawa, S., Fujita, T., Shimabukuro, M., Iwaki, M., Yamada, Y., Nakajima, Y., Nakayama, O., Makishima, M., Matsuda, M. and Shimomura, I. 2004. Increased oxidative stress in obesity and its impact on metabolic syndrome. J. Clin. Invest. 114, 1752-1761.   DOI
8 Hempstead, B. 2006. Dissecting the diverse actions of proand mature neurotrophins. Curr. Alzheimer Res. 3, 19-24.   DOI
9 Hristova, M. and Aloe, L. 2006. Metabolic syndrome-neurotrophic hypothesis. Med. Hypotheses. 66, 545-549.   DOI
10 Komamura, K., Miyazaki, J., Imai, E., Matsumoto, K., Nakamura, T. and Hori, M. 2008. Hepatocyte growth factor gene therapy for hypertension. Methods Mol. Biol. 423, 393-404.   DOI
11 Levinger, I., Goodman, C., Matthews, V., Hare, D. L., Jerums, G., Garnham, A. and Selig, S. 2008. BDNF, metabolic risk factors, and resistance training in middle-aged individuals. Med. Sci. Sports Exerc. 40, 535-541.   DOI   ScienceOn
12 Neeper, S. A., Gómez-Pinilla, F., Choi, J. and Cotman, C. W. 1996. Physical activity increases mRNA for brain-derived neurotrophic factor and nerve growth factor in rat brain. Brain Res. 726, 49-56.   DOI   ScienceOn
13 Nisoli, E., Tonello, C., Benarese, M., Liberini, P. and Carruba, M. O. 1996. Expression of nerve growth factor in brown adipose tissue: implications for thermogenesis and obesity. Endocrinology 137, 495-503.   DOI
14 Radak, Z., Toldy, A., Szabo, Z., Siamilis, S., Nyakas, C., Silye, G., Jakus, J. and Goto, S. 2006. The effects of training and detraining on memory, neurotrophins and oxidative stress markers in rat brain. Neurochem. Int. 49, 387-392.   DOI
15 Rajala, M. W. and Scherer, P. E. 2003. Minireview: The adipocyte-- at the crossroads of energy homeostasis, inflammation, and atherosclerosis. Endocrinology 144, 3765-3773.   DOI   ScienceOn
16 Schulz, K. H., Gold, S, M., Witte, J., Bartsch, K., Lang, U. E., Hellweg, R., Reer, R., Braumann, K. M. and Heesen, C. 2004. Impact of aerobic training on immune-endocrine parameters, neurotrophic factors, quality of life and coordinative function in multiple sclerosis. J. Neurol. Sci. 15, 11-18.
17 Yasuda, S., Goto, Y., Takaki, H., Asaumi, Y., Baba, T., Miyazaki, S. and Nonogi, H. 2004. Exercise-induced hepatocyte growth factor production in patients after acute myocardial infarction: its relationship to exercise capacity and brain natriuretic peptide levels. Circ. J. 68, 304-307.   DOI
18 Steers, W. and Tuttle, J. 2006. Mechanisms of Disease: the role of nerve growth factor in the pathophysiology of bladder disorders. Nature Clin. Prac. Urology 3, 101-110.   DOI
19 Wang, B., Jenkins, J. R. and Trayhurn, P. 2005. Expression and secretion of inflammation-related adipokines by human adipocytes differentiated in culture: integrated response to TNF-alpha. Am. J. Physiol. Endocrinol. Metab. 288, E731-740.
20 Woo, J. and Kang, S. 2008. The effects of individual calory consumption training on oxidation - antioxidation system in obese children. Kor. J. Sports Sci. 19, 75-81.