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http://dx.doi.org/10.5352/JLS.2012.22.3.298

Lutein Modulates Th2 Immune Response in Ovalbumin-Induced Airway Inflammation  

Song, Jun-Young (Department of Internal Medicine, Pusan National University School of Medicine)
Lee, Chang-Min (Section of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yale University School of Medicine)
Lee, Min-Ki (Department of Internal Medicine, Pusan National University School of Medicine)
Publication Information
Journal of Life Science / v.22, no.3, 2012 , pp. 298-305 More about this Journal
Abstract
The general term flavonoids is often used to categorize a family of natural compounds that are highly abundant in all higher plants, and which in recent years have attracted scientific interest as therapeutics. Lutein is a xanthophyll and one of 600 known naturally occurring carotenoids. It is found in green vegetables such as spinach and kale, and has been demonstrated to exert anti-inflammatory activities. However, its anti-allergic effect in the Th1/Th2 immune response is poorly understood. In this study, we attempt to determine whether lutein regulates inflammatory mediators in an ovalbumin (OVA)-induced murine asthma model. To address this, mice were sensitized and challenged with OVA, and then treated with lutein before the last OVA challenge. Administration of lutein significantly suppressed the OVA-induced airway hyper-responsiveness. It also resulted in a significant alleviation of the infiltration of inflammatory cells into the bronchoalveolar lavage. Additionally, lutein attenuated the increased expression of Th2 responses in OVA-challenged mice. These results demonstrate that lutein is a potent inhibitor that reduces Th2 immune responses. Furthermore, they show that the immunopharmacological function is mediated by a pathway that involves and is regulated by Th2 immune response.
Keywords
Asthma; lutein; GATA-3; Th1/Th2 balance; STAT-6;
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