Molecular Mechanisms through Which Peptidoglycan Induces IL-1β Expression in Monocytic Cells
![]() |
Seo, Hyun-Cheol
(Department of Pharmacology, Pusan National University School of Medicine)
Kim, Sun-Mi (Department of Pharmacology, Pusan National University School of Medicine) Lee, Sae-A (Department of Pharmacology, Pusan National University School of Medicine) Rhim, Byung-Yong (Department of Pharmacology, Pusan National University School of Medicine) Kim, Koanhoi (Department of Pharmacology, Pusan National University School of Medicine) |
1 | Chi, H., Messas, E., Levine, R. A., Graves, D. T. and Amar, S. 2004. Interleukin-1 receptor signaling mediates atherosclerosis associated with bacterial exposure and/or a high-fat diet in a murine apolipoprotein E heterozygote model: pharmacotherapeutic implications. Circulation 110, 1678-1685. DOI |
2 | Dinarello, C. A. 1997. Interleukin-1. Cytokine Growth Factor Rev. 8, 253-265. DOI |
3 | Dobrina, A., Nardon, E., Vecile, E., Cinco, M. and Patriarca, P. 1995. Leptospira icterohemorrhagiae and leptospire peptidolgycans induce endothelial cell adhesiveness for polymorphonuclear leukocytes. Infect. Immunol. 63, 2995-2999. |
4 | Galea, J., Armstrong, J., Gadsdon, P., Holden, H., Francis, S. E. and Holt, C. M. 1996. Interleukin-1 beta in coronary arteries of patients with ischemic heart disease. Arterioscler. Thromb. Vasc. Biol. 16, 1000-1006. DOI |
5 | Hahn-Windgassen, A., Nogueira, V., Chen, C. C., Skeen, J. E., Sonenberg, N. and Hay, N. 2005. Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity. J. Biol. Chem. 280, 32081-32089. DOI |
6 | Kavita, U. and Mizel, S. B. 1995. Differential sensitivity of interleukin-1 alpha and -beta precursor proteins to cleavage by calpain, a calcium-dependent protease. J. Biol. Chem. 270, 27758-27765. DOI |
7 | Kavoosi, G., Ardestani, S. K. and Kariminia, A. 2009. The involvement of TLR2 in cytokine and reactive oxygen species (ROS) production by PBMCs in response to Leishmania major phosphoglycans (PGs). Parasitology 136, 1193-1199. DOI |
8 | Kawai, T. and Akira, S. 2006. TLR signaling. Cell Death Differ. 13, 816-825. DOI |
9 | Kirii, H,. Niwa, T., Yamada, Y., Wada, H., Saito, K., Iwakura, Y., Asano, M., Moriwaki, H. and Seishima, M. 2003. Lack of interleukin-1beta decreases the severity of atherosclerosis in ApoE-deficient mice. Arterioscler. Thromb. Vasc. Biol. 23, 656-660. DOI |
10 | Laman, J. D., Schoneveld, A. H., Moll, F. L., van Meurs, M. and Pasterkamp, G. 2002. Significance of peptidoglycan, a proinflammatory bacterial antigen in atherosclerotic arteries and its association with vulnerable plaques. Am. J. Cardiol. 90, 119-123. DOI |
11 | Langer, M., Malykhin, A., Maeda, K., Chakrabarty, K., Williamson, K. S., Feasley, C. L., West, C. M., Metcalf, J. P. and Coggeshall, K. M. 2008. Bacillus anthracis peptidoglycan stimulates an inflammatory response in monocytes through the p38 mitogen-activated protein kinase pathway. PLoS One 3, e3706. DOI |
12 | Lee, S. A., Kim, S. M., Son, Y. H., Lee, C. W., Chung, S. W., Eo, S. K., Rhim, B. Y. and Kim, K. 2011. Peptidoglycan enhances secretion of monocyte chemoattractants via multiple signaling pathways. Biochem. Biophys. Res. Commun. 408, 132-138. DOI |
13 | Loppnow, H. and Libby, P. 1990. Proliferating or interleukin 1-activated human vascular smooth muscle cells secrete copious interleukin 6. J. Clin. Invest. 85, 731-738. DOI |
14 | Manning, B. D. and Cantley, L. C. 2007. AKT/PKB signaling: navigating downstream. Cell 129, 1261-1274. DOI ScienceOn |
15 | Miesel, R., Sanocka, D., Kurpisz, M. and Kroger, H. 1995. Antiinflammatory effects of NADPH oxidase inhibitors. Inflammation 19, 347-362. DOI |
16 | Moyer, C. F., Sajuthi, D., Tulli, H. and Williams, J. K. 1991. Synthesis of IL-1 alpha and IL-1 beta by arterial cells in atherosclerosis. Am. J. Pathol. 138, 951-960. |
17 | Sironi, M., Breviario, F., Proserpio, P., Biondi, A., Vecchi, A., Van Damme, J., Dejana, E. and Mantovani, A. 1989. IL-1 stimulates IL-6 production in endothelial cells. J. Immunol. 142, 549-553. |
18 | Nijhuis, M. M., Pasterkamp, G., Sluis, N. I., de Kleijn, D. P., Laman, J. D. and Ulfman, L. H. 2007. Peptidoglycan increases firm adhesion of monocytes under flow conditions and primes monocyte chemotaxis. J. Vasc. Res. 44, 214-222. DOI ScienceOn |
19 | Shaw, R. J. and Cantley, L. C. 2006. Ras, PI(3)K and mTOR signalling controls tumour cell growth. Nature 441, 424-430. DOI |
20 | Sica, A., Wang, J. M., Colotta, F., Dejana, E., Mantovani, A., Oppenheim, J. J., Larsen, C. G., Zachariae, C. O. and Matsushima, K. 1990. Monocyte chemotactic and activating factor gene expression induced in endothelial cells by IL-1 and tumor necrosis factor. J. Immunol. 144, 3034-3038. |
21 | Spagnuolo, G., D'Anto, V., Cosentino, C., Schmalz, G., Schweikl, H. and Rengo, S. 2006. Effect of N-acetyl-L-cysteine on ROS production and cell death caused by HEMA in human primary gingival fibroblasts. Biomaterials 27, 1803-1809. DOI |
22 | Suzuki, H., Shibano, K., Okane, M., Kono, I., Matsui, Y., Yamane, K. and Kashiwagi, H. 1989. Interferon-gamma modulates messenger RNA levels of c-sis (PDGF-B chain), PDGF-A chain, and IL-1 beta genes in human vascular endothelial cells. Am. J. Pathol. 134, 35-43. |
23 | Thobe, B. M., Frink, M., Hildebrand, F., Schwacha, M. G., Hubbard, W. J., Choudhry, M. A. and Chaudry, I. H. 2007. The role of MAPK in Kupffer cell toll-like receptor (TLR) 2-, TLR4-, and TLR9-mediated signaling following trauma-hemorrhage. J. Cell. Physiol. 210, 667-675. DOI |
24 | Wang, Q., Dziarski, R., Kirschning, C. J., Muzio, M. and Gupta, D. 2001. Micrococci and peptidoglycan activate TLR2, MyD88, IRAK, TRAF, NIK, IKK, NF-kappaB signal transduction pathway that induces transcription of interleukin-8. Infect. Immunol. 69, 2270-2276. |
25 | Barksby, H. E., Lea, S. R., Preshaw, P. M. and Taylor, J. J. 2007. The expanding family of interleukin-1 cytokines and their role in destructive inflammatory disorders. Clin. Exp. Immunol. 149, 217-225. DOI ScienceOn |
26 | Wang, Z. M., Liu, C. and Dziarski, R. 2000. Chemokines are the main proinflammatory mediators in human monocytes activated by Staphylococcus aureus, peptidoglycan, and endotoxin. J. Biol. Chem. 275, 20260-20267. DOI ScienceOn |
27 | Yoshimura, A., Lien, E., Ingalls, R. R., Tuomanen, E., Dziarski, R. and Golenbock, D. 1999. Cutting edge: recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2. J. Immunol. 163, 1-5. |
28 | Akira, S., Uematsu, S. and Takeuchi, O. 2006. Pathogen recognition and innate immunity. Cell 124, 783-801. DOI ScienceOn |
![]() |