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http://dx.doi.org/10.5352/JLS.2012.22.11.1558

Model Systems in Radiation Biology: Implication for Preclinical Study of Radiotherapy  

Kim, Wanyeon (Department of Biological Sciences, College of Natural Sciences, Pusan National University)
Seong, Ki Moon (Division of Radiation Effect Research, Radiation Health Research Institute, Korea Hydro & Nuclear Power Co., Ltd.)
Yang, Hee Jung (Department of Biological Sciences, College of Natural Sciences, Pusan National University)
Youn, HyeSook (Department of Bioscience & Biotechnology/Institute of Bioscience, Sejong University)
Youn, BuHyun (Department of Biological Sciences, College of Natural Sciences, Pusan National University)
Publication Information
Journal of Life Science / v.22, no.11, 2012 , pp. 1558-1570 More about this Journal
Abstract
In radiation biology, analysis of various mechanisms in response to radiation has been accomplished with the use of model organisms. These model organisms are powerful tools for providing a biologically intact in vivo environment to assess physiological and pathophysiological processes affected by radiation. Accumulated data using these models have been applied to human clinical studies (including the evaluation of radiotherapeutic efficacy) and discovery of radiotherapy reagents. However, there are few studies to provide overall integrated information about these useful model organisms. Thus, this review summarizes the results of radiation biology studies using four well-known model organisms: yeast, Caenorhabditis elegans, Drosophila melanogaster, and mice.
Keywords
Radiation biology; yeast; C. elegans; D. melanogaster; mouse;
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