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http://dx.doi.org/10.5352/JLS.2012.22.10.1352

PAF in Pulmonary Surfactant Contributes to Neutrophilic Oxidative Stress-Induced Acute Lung Injury of Rats Given LPS Intratracheally  

Lee, Young-Man (Department of Physiology, School of Medicine, Daegu Catholic University)
Publication Information
Journal of Life Science / v.22, no.10, 2012 , pp. 1352-1358 More about this Journal
Abstract
In acute lung injury (ALI) by lipopolysaccharide (LPS), the underlying cause of infiltration and migration of neutrophils into the alveoli is considered to be from increased production of platelet-activating factor (PAF) in the pulmonary surfactant lining the alveolar lumen. In this study I partially confirmed this concept. LPS increased lung leak and the infiltration of neutrophils in the lung of rats given LPS intratracheally. The migration of neutrophils into the lung, which had caused oxidative stress, was also morphologically identified. I verified that the metabolism of the pulmonary surfactant was affected and that there was increased production of PAF in the pulmonary surfactant, both of which are considered to contribute to ALI by LPS in rats.
Keywords
Lipopolysaccharide (LPS); acute lung injury; pulmonary surfactant; platelet-activating factor (PAF);
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1 Bligh, E. G. and Dyer, W. J. 1959. A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol. 37, 911-917.   DOI
2 Brown, R. E., Jarvis, J. L. and Hyland, K. J. 1989. Protein measurement using bicinchoninic acid: elimination of interfering substance. Anal. Biochem. 180, 136-139.   DOI   ScienceOn
3 Corbet, A., Cregan, J., Frink, J. and Rudolph, A. J. 1983. Distension-produced phospholipid secretion in postmortem in situ lungs of newborn rabbits: inhibition by specific beta- adrenergic blockade. Am. J. Respir. Dis. 128, 695-701.
4 Goldblum, S. E., Wu, K. E. and Jay, M. 1985. Lung myeloperoxidase as a measurement of leukostasis in rabbits. J. Appl. Physiol. 119, L104-112.
5 Hess, H. H. and Derr, J. E. 1975. Assay of inorganic and organic phosphorus in the 0.1-5 nanomolar range. Anal. Biochem. 63, 607-613.   DOI   ScienceOn
6 Hite, R. D., Seeds, M. C., Jacinto, R. B., Balasubramania, R. and Waite, M. 1998. Hydrolysis of surfactant associated phosphatidylcholine by mammalian secretory phospholipase A2. Am. J. Physiol. 275, L740-747.
7 Hobson, J., Wright, J. and Churg, A. 1991. Histochemical evidence for generation of active oxygen species on the apical surface of cigarette-smoke-exposed tracheal explants. Am. J. Pathol. 139, 442-447.
8 Holm, B. A., Keicher, L., Liu, M. A., Sokolowski, J. and Enhorning, G. 1991. Inhibition of pulmonary surfactant function by phospholipases. J. Appl. Physiol. 71, 317-321.
9 Ikegami, M., Kallapur, S., Michna, J. and Jobe, A. H. 2000. Lung injury and surfactant metabolism after hyperventilation of premature lambs. Pediatr. Res. 47, 398-404.   DOI
10 Kirsch, C. M., Brokaw, J. J., Prow, D. M. and White, G. W. 1992. Mechanism of platelet-activating factor-induced vascular leakage in the rat trachea. Exp. Lung Res. 18, 447-459.   DOI
11 Lee, Y. M., Hybertson, B. M., Cho, H. G., Terada, L. S., Cho, O., Repine, A. J. and Repine, J. E. 2000. Platelet-activating factor contributes to acute lung leak in rats given interleukin-1 intratracheally. Am. J. Physiol. Lung Cell. Mol. Physiol. 279, L75-80.
12 Martensson, J. A., Jain, J. A., Frayer, W. and Meister, A. 1989. Glutathione metabolism in the lung: inhibition of its synthesis leads to lamellar body and mitochondrial defects. Proc. Natl. Acad. Sci. 86, 5296-5233.   DOI   ScienceOn
13 Lee, Y. M., Hybertson, B. M., Terada, L. S., Repine, A. J., Cho, H. G. and Repine, J. E. 1997. Mepacrine decreases lung leak in rats given interleukin-1 intratracheally. Am. Rev. Respir. Crit. Care Med. 155, 1624-1628.   DOI   ScienceOn
14 Lee, Y. M., Hybertson, B. M., Cho, H. G. and Repine, J. E. 2002. Platelet-activating factor induces lung inflammation and leak in rats: hydrogen peroxide production along neutrophil- lung endothelial cell interfaces. J. Lab. Clin. Med. 140, 312-319.   DOI   ScienceOn
15 Liau, D. F., Barret, C. R., Bell, A. L. and Ryan, S. F. 1987. Functional abnormalities of lung surfactant in experimental acute alveolar injury in the dog. Am. Rev. Repir. Dis. 136, 395-401.   DOI
16 Minayama, Y., Tozawa, K., Kitamura, M., Saito, S. and Ogawa, J. 1998. Platelet-activating factor mediates intracellular adhesion molecule-1-dependent radical production in the non-hypoxic ischemia rat lung. Am. J. Cell. Mol. Biol. 19, 150-157.   DOI   ScienceOn
17 Mitola, J. M., Jeffrey, P. K. and Hellewell, P. G. 1998. Platelet-activating factor plays a pivotal role in the induction of experimental lung injury. Am. J. Respir. Cell. Mol. Biol. 18, 197-204.   DOI   ScienceOn
18 Moya, F. R., Hoffman, D. R., Zhao, B. and Johnston, J. M. 1993. Platelet-activating factor in pulmonary surfactant preparation. Lancet 341, 858-860.   DOI
19 Nakos, G., Kitsiouli, E., Hatzidaki, E., Koulouras, V., Touqui, L. and Lekka, M. E. 2005. Phospholipase A2 and platelet- activating factor acetylhydrolase in patients with acute respiratory syndrome. Crit. Care Med. 33, 772-779.   DOI
20 Putman, E. J., Boere, F. Van Bree, L., Golde, L. M. G. and Haagman, H. P. 1995. Pulmonary surfactant subtype metabolism is altered after short-term ozone exposure. Toxicol. Appl. Pharmacol. 134, 132-138.   DOI
21 Ribaldi, E., Mezzasoma, A. M., Francecangeli, E., Prosdicimi, M., Nenci, G. G. and Gresele, P. 1996. Inhibition of PAF synthesis by stimulated human polymorphonuclear leucocytes with cloricromene, an inhibitor of phospholipase A2 activation. British J. Pharmacol. 118, 1351-1358.   DOI
22 Shin, T. R., Na, B. K. and Lee, Y. M. 2005. Protective effect of the inhibition of PAF remodeling and adhesion molecule on the oxidative stress of the lungs of rats given endotoxin intratracheally. Tuberc. Respire. Dis 58, 276-284.
23 Sorensen, J., Kald, B., Tagesson, C. and Lindahl, M. 1994. Platelet-activating factor and phospholipase A2 in patients with septic shock and trauma. Intensive Care Med. 20, 551-561.
24 Triggiani, M., Marino, V. D., Sofia, M., Faraone, S., Ambrosio, G., Carratu, L. and Marone, G. 1997. Characterization of platelet-activating factor acetylhydrolase in human bronchoalveolar lavage. Am. J. Respir. Crit. Care Med. 156, 94-100.   DOI   ScienceOn