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http://dx.doi.org/10.5352/JLS.2012.22.10.1339

Inhibitory Effect of PG-Platycodin D on the Development of Atopic Dermatitis-Like Skin Lesions in ICR Mice  

Park, Sae-Jin (Division of Biological Science and Technology, College of Science and Technology, Yonsei University)
Kim, Yoon Suk (Department of Biomedical Laboratory Science, College of Health Sciences, Yonsei University)
Kim, Tack-Joong (Division of Biological Science and Technology, College of Science and Technology, Yonsei University)
Publication Information
Journal of Life Science / v.22, no.10, 2012 , pp. 1339-1343 More about this Journal
Abstract
Atopic dermatitis is characterized by chronically pruritic and inflammatory dermatitis. In this study, we investigated the effect of Platycodon grandiflorum including platycodin D (PG-Platycodin D) in an atopic dermatitis-like mouse model. An atopic dermatitis-like skin lesion was induced by repeated treatment of 2,4-dinitrochlorobenzene (DNCB) on the dorsal skin of ICR mice. The efficacy of PG-Platycodin D was tested by observing scratching behavior, the skin severity score, and histopathologic analysis. PG-Platycodin D reduced the DNCB-induced increase in scratching behavior and the skin severity score. In addition, histopathologic analysis revealed a reduction in the thickening of the epidermis in the PG-Platycodin D group. These results may contribute to the development of a therapeutic drug for the treatment of atopic dermatitis.
Keywords
Atopic dermatitis; PG-playticodin D; severity score; scratching behavior;
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