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http://dx.doi.org/10.5352/JLS.2011.21.9.1310

Septicine Inhibits the Production of Inflammatory Mediators in Lipopolysaccharide-Stimulated Murine Macrophages  

Park, Geun-Mook (Department of Biomedical Science, College of Natural Science, Catholic University of Daegu)
Kim, Jin-Kyung (Department of Biomedical Science, College of Natural Science, Catholic University of Daegu)
Publication Information
Journal of Life Science / v.21, no.9, 2011 , pp. 1310-1314 More about this Journal
Abstract
Anti-inflammatory activities of septicine, a natural alkaloid product present in the leaves and stems of Tylophora ovata, were evaluated in lipopolysaccharide (LPS)-stimulated murine macrophages, RAW264.7 cells. Treatment with septicine inhibited LPS-induced nitric oxide (NO), inflammatory cytokines, tumor necrosis factor-${\alpha}$ and interleukin-6 production in a concentration-dependant manner. In addition, septicine suppressed the expression of inducible NO synthase. These results suggest that the anti-inflammatory activities of septicine might be attributed to the inhibition of NO, iNOS and cytokine expression.
Keywords
Inflammation; lipopolysaccharide; macrophages; septicine;
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