Browse > Article
http://dx.doi.org/10.5352/JLS.2011.21.8.1142

Biological Activities of Ethanol Extracts from Monascus-Fermented Chinese Yam  

Jeon, Chun-Pyo (Department of Medicine Quality Analysis, Andong Science College)
Lee, Jung-Bok (Department of Optometry, Kundong University)
Choi, Chung-Sig (Bio Industry Institute, HansBio Co., Ltd.)
Kwon, Gi-Seok (School of Bioresource Sciences, Andong National University)
Publication Information
Journal of Life Science / v.21, no.8, 2011 , pp. 1142-1148 More about this Journal
Abstract
This study was conducted to investigate antioxidative and physiological activities of ethanol extracts concentration from Monascus-Fermented Chinese Yam (MFCY). The ethanol extracts from MFCY were measured to examine pigment, monacolin K content, total polyphenol content, DPPH radical scavenging activity and angiotensin converting enzyme inhibitory effects. In this study, the results show that Monascus sp. MK2, with Dioscorea batatas Dence. as the substrate, can produce pigments (red, orange, and yellow), monacolin K content, total polyphenol content and DPPH radical scavenging activity at 13.48 (red), 11.66 (orange), 12.77 (yellow), 462.78 (mg/kg), 658.8 (mg/kg) and 92.8% in EtOH extract, respectively. In addition, ACE inhibitory activity was shown to be 74.55% in EtOH extract. Therefore, it can be concluded that Dioscorea batatas Dence is the best fermentative substrate for Monascus species to produce secondary metabolites as biomedicinal substances.
Keywords
Angiotensin converting enzyme (ACE) inhibitory activity; biological activities; Dioscorea batatas Dence; Monascus sp.; Monascus-Fermented Chinese Yam;
Citations & Related Records
Times Cited By KSCI : 16  (Citation Analysis)
연도 인용수 순위
1 Kwon, C. S., H. Y. Shon, S. H. Kim, J. H. Kim, G. H. Son, J. S. Lee, J. K. Lim, and J. S. Kim. 2003. Anti-obesity effect of Dioscorea nipponica Makino with lipase-inhibitory activity in rodents. Biosci. Biotechnol. Biochem. 67, 1451-1456.   DOI
2 Kwon, C. S., I. S. Son, H. Y. Shim, I. S. Kwon, and K. M. Chung. 1999. Effects of yam on lowering cholesterol level and its mechanism. Korean J. Food Nutr. 32, 637-643.   과학기술학회마을
3 Kwon, H. N., J. R. Park, and J. R. Jeon. 2008. Antioxidative and hepatoprotective effects of Acer tegmentosum M. Extracts. Korean J. Soc. Food Sci. Nutr. 37, 1389-1394.   과학기술학회마을   DOI
4 Lee, C. L., J. J. Wang, S. L. Kuo, and T. M. Pan. 2006. Monascus fermentation of dioscorea for increasing the production of cholesterol-lowering agent-monacolin K and antiinflammation agent-monascin. Appl. Microbiol. Biotechnol. 72, 1254-1262.   DOI
5 Ferreres, F., D. Gomes, P. Valentão, R. Gonçalves, R. Pio, E. A. Chagas, R. M. Seabra, and P. B. Andrade. 2009. Improved loquat (Eriobotrya japonica Lindl.) cultivars: Variation of phenolics and antioxidative potential. Food Chem. 114, 1019-1027.   DOI
6 Ha, Y. D., S. P. Lee, and Y. G. Kwak. 1998, Removal of Heavy metal and ACE inhibition of yam mucilage. Korean J. Soc. Food Sci. Nutr. 27, 751-755.   과학기술학회마을
7 Hertog, M. G. L., P. C. H. Hollman, and M. B. Katan. 1992. Content of potentially anticarcinogenic flavonoids of 28 vegetables and 9 fruits commonly consumed in the Netherlands. J. Agric. Food Chem. 40, 2379-2383.   DOI
8 Hwang, J. and T. H. Hseu. 1980. Specificity of the acid protease from Monascus kaoliang toward the-B-chain of oxidized insulin. Biochemica et Biophysica Acta. 614, 607-612.   DOI   ScienceOn
9 Jeon, C. P., C. S. Kim, J. B. Lee, J. W. Shin, S. Y. Choi, C. S. Choi, O. S. Lee, and G. S. Kwon. 2007. Characteristics of monascus natural pigments produced by Monascus sp. MK2-2. J. Life Sci. 17, 137-142.   과학기술학회마을   DOI
10 Jeon, C. P., J. B. Lee, S. Y. Choi, O. S. Lee, C. S. Choi, and G. S. Kwon. 2006. Optimal conditions for production of water- soluble monascus natural pigments by Monascus purpureus MK2. Korean J. Microbiol. Biotechnol. 34, 250- 256.   과학기술학회마을
11 Judie, D. D. 1987. Applications and colorants, Food Technol 23, 78-88.
12 Jung, D. H. 2007. In: Encyclopedia of health and functional foods. Shinil Books Publishing Co., Seoul, Korea. Ma, 191-192.
13 Kang, Y. H., Y. K. Park, and G. D. Lee. 1996. The nitrite scavenging and electron donating ability of phenolic compounds. Korean J. Food Sci. Technol. 28, 232-239.   과학기술학회마을
14 Bilheimer, D. W., S. M. Grundy, M. S. Brown, and J. L. Goldstein. 1983. Mevinolin and colestipol stimulate receptor mediated clearance of low density lipoprotein from plasma in familial hypercholesterolemia heterozygotes. Proc. Natl. Acad. Sci. USA 80, 4124-4128.   DOI
15 Blois, M. S. 1958. Antioxidant determinations by the use of a stable free radical. Nature 181, 1199-1200.   DOI
16 Cha, J. Y., H. Y. Ahn, K. E. Eom, B. K. Park, B. S. Jun, and Y. S. Cho. 2009. Antioxidative activity of Aralia elata shoot and leaf extracts. J. Life Sci. 19, 652-658.   DOI
17 Cushman, D. W. and H. S. Cheung. 1971. Spectrophotometric assay and properties of the angiotensin- converting enzyme of rabbit lung. Biochem. Pharmacol. 20, 1637-1648.   DOI
18 Cha, J. Y., J. J. Jeong, Y. T. Kim, W. S. Seo, H. J. Yang, J. S. Kim, and Y. S. Lee. 2006. Detection of chemical characteristics in Hamcho (Salicornia herbacea L.) according to harvest periods. J. Life Sci. 16, 683-690.   과학기술학회마을   DOI
19 Choi, C. S. and C. P. Jeon. 2009. Red yeast rice industry and green growth. J. Korean Soc. Food Sci. Nutr (Food industry and Nutrition). 14, 25-32.   과학기술학회마을
20 Chung, H. J. 1999. Antioxidative effect of ethanolic extracts of some tea materials on red pepper seed oil. Korean J. Soc. Food Sci. Nutr. 28, 1316-1320.   과학기술학회마을
21 Editorial, D. Useful microbe as health food material. 2000. Food and development 35, 44-48.
22 Endo, A. 1979. Monacolin K, a new hypocholesterolemic agent produced by a Monascus species. J. Antibiotics. 32, 852-854.   DOI
23 Endo, A., M. Kuroda, and Y. Tsujita. 1976. ML- 236A, ML-236B, and ML- 236C, new inhibitors of cholesterogenesis produced by Penicillium citrinum. J. Antibiot. 29, 1346-1348.   DOI
24 Lin, C. F. 1973. Isolation and cultural conditions of Monascus sp. for the production of pigment in a submerged culture. J. Ferment. Technol. 51, 107-114.
25 Ainsworth, G. C., F. K. Sparrowr, and A. S. Sassman. The fungi. 1973. Academic press, New York. 35.
26 Baek, S. H., S. H. Kim, K. H. Son, K. C. Chung, and H. W. Chang. 1994. Inactivation of human pleural fluid phospholipse A2 by dioscin. Arch. Pharm. Res. 17, 218-222.   DOI
27 Sweny, J. G., M. C. Estrada-Valdes, G. A. Iacobucci, H. Sato, and S. Sakamura. 1981. Photoprotection of the red pigments of Monascus anka in aqueous media by 1,4,6-trihydroxynaphthalene. J. Agric. Food Chem. 29, 1189-1193.   DOI
28 Wong, H. C. and P. E. Koehler. 1983. Production of red water- soluble Monascus pigments. J. Food Sci. 48, 1200-1203.   DOI
29 Lee, I. S., S. Y. Chung, C. S. Shim, and S. J. Koo. 1995. Inhibitory effects of yam (Dioscorea batatas Dence) extracts on the mutagenicity. Korean J. Soc. Food Sci. 11, 351-355.
30 Lee, S. M., H. S. Kim, and T. S. Yu. 2003. The optimal condition for production of red pigment by Monascus anka on solid culture. J. Korean Soc. Food Sci. Nutr. 32, 155-160.   과학기술학회마을   DOI
31 Lin, C. F. and H. Iizuka. 1982. Production of extracellular pigments by mutant of Monascus Kaoliang sp. nov. Appl. Environ. Microbiol. 43, 671-676.
32 Noh, H. and K. B. Song. 2001. Isolation of an angiotensin converting enzyme inhibitor from Oenanthe javanica. Agric. Chem. Biotechnol. 44, 98-99.
33 Su, Y. C. Properties of Monascus anka and its utilization. 1975. J. Ferment. Assoc. 33, 28-34.
34 Oh, S. J., S. H. Kim, S. K. Kim, Y. J. Baek, and K. H. Cho. 1997. Angiotensin I- converting enzyme inhibitory activity of the K-casein fragments hydrolysated by chymosin, pepsin, and trypsin. Korean J. Food Sci. Technol. 29, 1316-1318.   과학기술학회마을
35 Park, J. C., J. Y. Cha, C. H. Lee, E. S. Doh, I. H. Kang, and Y. S. Cho. 2009. Biological activities and chemical characteristics of Monascus-fermented Korean red ginseng. J. Life Sci. 19, 1553-1561.   과학기술학회마을   DOI
36 Purseglove, J. W. 1972. Dioscoreaceae. Tropocal crops monocotylodons. In Longman, I. (ed.), London. 97.
37 Swain, T., W. E. Hillis, and M. Oritega. 1959. Phenolic constituents of Prunus domestica. 1. Quantitative analysis of phenolic constituents. J. Sci. Food Agric. 10, 83-88.
38 Kim, C. M., K. H. Son, S. H. Kim, and H. P. Kim. 1991. Steroidal sapogenin contents in some domestic plants. Arch. Pharm. 14, 305-310.   과학기술학회마을   DOI
39 Kim, C. S., S. H. Rhee, and I. Kim. 1977. Studies on production and characteristics of edible red color pigment produced by mold (Monascus sp.). Korean J. Food Sci. Technol. 9, 277-283.   과학기술학회마을
40 Kim, J. Y. and K. H. Kim. 1997. Isolation and characterization of Bacillus sp. PY123 producing water-soluble yellow pigment. Korean J. Appl. Microbiol. Biotechnol. 25, 454-458.
41 Kwak, E. J., S. K. Cha, and S. I. Lim. 2003. The optimal condition for the production and extraction of monacolin K from red-koji. Korean J. Food Sci. Technol. 35, 830-834.   과학기술학회마을