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http://dx.doi.org/10.5352/JLS.2011.21.7.932

Antihyperlipidemic Effect of Ginsenoside Rg1 in Type 2 Diabetic Mice  

Park, Jae-Hong (School of Korean Medicine, Pusan National University)
Lee, Ji-Youn (School of Korean Medicine, Pusan National University)
Yeo, Ji-Young (School of Korean Medicine, Pusan National University)
Nam, Jeong-Su (School of Korean Medicine, Pusan National University)
Jung, Myeong-Ho (School of Korean Medicine, Pusan National University)
Publication Information
Journal of Life Science / v.21, no.7, 2011 , pp. 932-938 More about this Journal
Abstract
Ginsenoside Rg1 is a pharmacologically active component isolated from ginseng. The goal of this study was to clarify the beneficial effects of Rg1 on glucose and lipid metabolism in diabetic animals (db/db mice). To accomplish this, ten week old db/db mice were administered 10 mg/kg of Rg1 for 15 days. Rg1 did not influence the weight of db/db mice when compared with vehicle-treated db/db mice. The administration of Rg1 lowered fasting plasma glucose, and improved glucose tolerance. Importantly, Rg1 markedly reduced both plasma triglyceride and free fatty acids, and increased high-density lipoprotein cholesterol (HDL-C) concentrations in db/db mice. Rg1 activated promoter activity of chimeric GAL4-PPAR${\alpha}$ reporter and increased expression of peroxisome proliferator-activated receptor alpha (PPAR${\alpha}$) target genes such as carnitine palmitoyltransferase-1 (CPT-1) and acyl-CoA oxidase (ACO), which are involved in fatty acid oxidation. These findings indicated that improvement of lipid profiles by Rg1 may be associated with increased fatty acid oxidation via PPAR${\alpha}$ activation. Taken together, these results suggest that Rg1 could have beneficial effects for controlling hyperglycemia and hyperlipidemia associated with type 2 diabetes.
Keywords
Ginsenoside Rg1; type 2 diabetes; hyperlipidemia; db/db mice;
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