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http://dx.doi.org/10.5352/JLS.2011.21.6.783

Thaumatin Isolated from Katemfe Fruit of Thaumatococcus daiellii Inhibits 3T3 L1 Adipocytes Differenciation  

Cha, Jae-Young (Technical Research Institute, Daesun Distilling Co., Ltd.)
Jeong, Jae-Jun (Technical Research Institute, Daesun Distilling Co., Ltd.)
Yang, Hyun-Ju (Technical Research Institute, Daesun Distilling Co., Ltd.)
Park, Jun-Seok (Technical Research Institute, Daesun Distilling Co., Ltd.)
Kim, Hyun-Woo (Technical Research Institute, Daesun Distilling Co., Ltd.)
Kim, Su-Hyun (Technical Research Institute, Daesun Distilling Co., Ltd.)
Jung, Hae-Jung (Technical Research Institute, Daesun Distilling Co., Ltd.)
Publication Information
Journal of Life Science / v.21, no.6, 2011 , pp. 783-787 More about this Journal
Abstract
The effects of thaumatin isolated from katemfe fruit of Thaumatococcus daiellii Benth on 3T3-L1 preadipocyte differentiation was investigated in vitro. 3T3-L1 adipocytes were treated with various concentrations of thaumatin ranging in 0-5 ${\mu}M$. Thaumatin reduced fat accumulation in differentiated 3T3-L1 adipocytes in a dose-dependent manner. 3T3-L1 cell proliferation was 97.0 and 88.3% at 1 and 3 ${\mu}M$ after 8 days of thaumatin treatment, respectively. Thaumatin showed a potent inhibitory effect on stained lipid droplets at a concentration of 3 ${\mu}M$. Thaumatin reduced triglyceride accumulation in differentiated 3T3-L1 cells in a dose-dependent manner, compared with positive control cells. This study provides basic information on the anti-obesity activity of thaumatin.
Keywords
3T3-L1 adipocyte cells; thaumatin; Thaumatococcus daiellii Benth; sweet-protein;
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