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http://dx.doi.org/10.5352/JLS.2011.21.4.604

Effect of Pine (Pinus densiflora) Needle Hot Water Extract on Antioxidant Activity in Rats Treated with Carbon Tetrachloride  

Park, Yong-Soo (Department Food and Nutrition, Silla University)
Park, Mi-Ra (Department Food and Nutrition, Silla University)
Jeon, Min-Hee (Department Food and Nutrition, Silla University)
Hwang, Hyun-Jung (Department Food and Nutrition, Silla University)
Kang, Min-Suk (Department Food and Nutrition, Silla University)
Kim, Bo-Kyung (Department Food and Nutrition, Silla University)
Kim, Sung-Gu (Bioport Korea Co.)
Lee, Sang-Hyeon (Department of Bioscience and Biotechnology, Silla University)
Kim, Mi-Hyang (Department Food and Nutrition, Silla University)
Publication Information
Journal of Life Science / v.21, no.4, 2011 , pp. 604-609 More about this Journal
Abstract
Pine (pinus densiflora) needles have long been used as a traditional health-promoting medicinal food in Korea. This study was conducted to investigate the effects of pine needle extracts on the hepatic antioxidant system in the damaged liver of carbon tetrachloride ($CCl_4$)-treated rats. Nine-week-old Sprague Dawley rats were divided into four groups: normal group (NOR), $CCl_4$-treated group (CCL), pine needle hot water extract and $CCl_4$-treated group (CCL-P), and Vitamin C and $CCl_4$-treated group (CCL-V). The enzyme activities and antioxidant effects of the pine needle hot water extracts were investigated at the levels of liver homogenates and serum of rats intoxicated with $CCl_4$. Serum GOT and GPT activities by $CCl_4$ treatment increased compared to those of the NOR group. However, they tended to decrease in the hot water extract-administered group. Liver SOD activity in the CCL group was significantly lower than the NOR group (p<0.05). However, they increased in the CCL-P group compared to the CCL group. Further, the CAT and GPx activities of serum treated with $CCl_4$ were higher compared to those of the NOR group but lower in the CCL-P group compared to CCL group. These results suggest that pine needle hot water extract increases antioxidant activities.
Keywords
Pine (Pinus densiflora) needle; antioxidant activity; superoxide dismutase (SOD); catalase (CAT); glutathione peroxidase (GPX);
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