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http://dx.doi.org/10.5352/JLS.2011.21.4.515

Immunomodulating Effect of Edible Mushrooms in Mice  

Park, Hyun-Ji (Chemon Inc.)
Heo, Yong (Department of Occupational Health, Catholic University of Daegu)
Kim, Jong-Bong (Department of Biomedical Science, Catholic University of Daegu)
Publication Information
Journal of Life Science / v.21, no.4, 2011 , pp. 515-520 More about this Journal
Abstract
This study was carried out to evaluate the immunomodulatory capacity of edible mushrooms, including Lepista nuda, Corprinis comatus, Letinus edodes, and Pleurotus eryngii, in mice. BALB/c mice were administered 1, 50, and 500 mg/kg body weight of various mushrooms five times a week over 4 weeks through gastric intubation. The control mice were administered distilled water. No significant changes in body weight were observed. IL-4 and IFN${\gamma}$ production was evaluated with splenic T lymphocytes stimulated in vitro with phytohemagglutinins for 48 hr. The mice group administered L. edodes showed significantly higher ratio of IFN${\gamma}$ versus IL-4 than the other groups. In addition, the ratio of plasma IgG2a versus IgG1 was also significantly elevated in mice treated with L. edodes. However, no significant change was observed in ratio of IgG2a versus IgG1 in splenic B lymphocytes stimulated in vitro with lipopolysaccharides for 7 days. These results indicate that L. edodes can enhance type-1 helper T cell-mediated cellular immunity.
Keywords
Mushroom; immunomodulator; anticancer; INF${\gamma}$; IL-4;
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