Browse > Article
http://dx.doi.org/10.5352/JLS.2011.21.3.459

Molecular Analysis of Alternative Transcripts of CCDC94 Gene in the Brain Tissues of Rhesus Monkey  

Yun, Se-Eun (Department of Biological Sciences, College of Natural Sciences, Pusan National University)
Ahn, Kung (Department of Biological Sciences, College of Natural Sciences, Pusan National University)
Kim, Heui-Soo (Department of Biological Sciences, College of Natural Sciences, Pusan National University)
Publication Information
Journal of Life Science / v.21, no.3, 2011 , pp. 459-463 More about this Journal
Abstract
The genome of the rhesus monkey has diverged as an average sequence identity of ~93%. The rhesus monkey has been widely used as a non-human primate in the field of biomedical and evolutional research. Insertion of transposable elements (TEs) induced several events such as transcriptional diversity and different expression in host genes. In this study, 112 transcripts were identified from a full-length cDNA library of brain tissues of the rhesus monkey. One transcript (R54) showed a different expression pattern between human and rhesus monkey tissues. This phenomenon can be an explanation that R54 transcript was acquired by splicing a donor site derived from exonization of the L2A element. Therefore, integration of TEs during primate radiation could contribute to transcriptional diversity and gene regulation.
Keywords
Rhesus monkey; brain cDNA library; CCDC94; gene expression; alternative splicing; primates;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
연도 인용수 순위
1 Lai, F., C. X. Chen, K. C. Carter, and K. Nishikura. 1997. Editing of glutamate receptor B subunit ion channel RNAs by four alternatively spliced DRADA2 double-stranded RNA adenosine deaminases. Mol. Cell Biol. 17, 2413-2424.
2 Landry, J. R. and D. L. Mager. 2003. Functional analysis of the endogernous retrovirol promoter of ger human ednothelin D receptor gene. J. Virol. 77, 7459-7766.   DOI
3 Lin, L., P. Jiang, S. Shen, S. Sato, B. L. Davidson, and Y. Xing. 2009. Large-scale analysis of exonized mammalian-wide interspersed repeats in primate genomes. Hum. Mol. Genet. 18, 2204-2214.   DOI
4 Locke, D. P. and et al. 2011. Comparative and demographic analysis of orang-utan genomes. Nature 469, 529-533.   DOI
5 McClintock, B. 1950. The origin and behavior of mutable loci in maize. Proc. Natl. Acad. Sci. USA 36, 344-55.   DOI
6 Mersch, B., N. Sela, G. Ast, S. Suhai, and A. Hotz-Wagenblatt. 2007. SERpredict: detection of tissue- or tumor- specific isoforms generated through exonization of transposable elements. BMC Genet. 8, 78.
7 Mills, R. E., E. A. Bennett, R. C. Iskow, and S. E. Devine. 2007. Which transposable elements areactive in the human genome? Trends Genet. 23, 183-191.   DOI
8 Modrek, B. and C. J. Lee. 2003. Alternative splicing in the human, mouse and rat genomes is associated with an increased frequency of exon creation and/or loss. Nat. Genet. 34, 177-180.   DOI
9 Osorio, A., A. Barroso, M. J. Garca, B. Martnez-Delgado, M. Urioste, and J. Bentez. 1999. Evaluation of the BRCA1 interacting genes RAP80 and CCDC98 in familial breast cancer susceptibility. Breast Cancer Res. Treat 113, 371-376.
10 Golub, M. S. 2010. Recent studies of iron deficiency during brain development in nonhuman primates. Biofactors 36, 111-116.
11 Portis, J. L. 2002. Perspectives on the role of endogenous human retroviruses in autoimmune diseases. Virology 296, 1-5.   DOI
12 Goodier, J. L. and H. H. Jr. Kazazian. 2008. Retrotransposons revisited: the restraint and rehabilitation of parasites. Cell 135, 23-35.   DOI
13 Hadjiargyrou, M., M. F. Halsey, W. Ahrens, E. P. Rightmire, K. J. McLeod, and C. T. Rubin. 1998. Cloning of a novel cDNA expressed during the early stages of fracture healing. Biochem. Biophys. Res. Commun. 249, 879-884.   DOI
14 Hayreh, S. S. and J. B. Jonas. 2000. Ophthalmoscopic detectability of the parafoveal annular reflex in the evaluation of the optic nerve: an experimental study in rhesus monkeys. Ophthalmology 107, 1009-1014.   DOI
15 Hsu, C. H., Y. Zhang, and R. C. Hardison. 2010. An effective method for detecting gene conversion events in whole genomes. J. Comput. Biol. 17, 1281-1297.   DOI
16 Huang, J., T. Shi, T. Ma, Y. Zhang, X. Ma, Y. Lu, Q. Song, W. Liu, D. Ma, and X. Qiu. 2009. CCDC134, a novel secretory protein, inhibits activation of ERK and JNK, but not p38 MAPK. Breast Cancer Res. Treat. 113, 371-376.   DOI
17 Huh, J. W., Y. H. Kim, D. S. Kim, S. J. Park, S. R. Lee, S. H. Kim, E. Kim, S. U. Kim, M. S. Kim, H. S. Kim, and K. T. Chang Kim. 2010. Alu-derived old world monkeys exonization event and experimental validation of the LEPR gene. Mol. Cells 30, 201-210.   DOI
18 Rhesus Macaque Genome Sequencing and Analysis Consoritum. 2007. Evolutionary and biomedical insights from the rhesus macaque genome. Science 316, 222-234.   DOI   ScienceOn
19 Johnstone, L. S., S. J. Graham, and M. A. Dziadek. 2010. STIM proteins: integrators of signalLung pathways in development, differentiation and disease. J. Cell Mol. Med. 14, 1890-1903.   DOI
20 Sin, H. S., J. W. Huh, K. Ahn, H. S. Ha, and H. S. Kim. 2007. Long terminal repeats of human endogenous retrovirus H family provide alternative polyadenylation signals to NADSYN1 gene. Korean J. Genet. 29, 395-401.   과학기술학회마을
21 Smith, C. W. and J. Valcarcel. 2000. Alternative pre-mRNA splicing: the logic of combinatorial control. Trends Biochem. Sci. 25, 381-388.   DOI
22 Sorek, R., R. Shamir, and G. Ast. 2004. How prevalent is functional alternative splicing in the human genome? Trends Genet. 20, 68-71.   DOI
23 Jurka, J. 2000. Repbase update: a database and an electronic journal of repetitive elements. Trends Genet. 16, 418-420.   DOI
24 Blikstad, V., F. Benachenhou, G. O. Sperber, and J. Blomberg. 2008. Evolution of human endogenous retroviral sequences: a conceptual account. Cell Mol. Life Sci. 65, 3348-3365.   DOI
25 International Human Genome Sequencing Consortium. 2010. Initial sequencing and analysis of the human genome. Nature 409, 560-921.
26 Bannert, N. and R. Kruth. 2006. The evolutionary dynamics of human endogenous retroviral familes. Annu. Rev. Genomics Hum. Genet. 7, 149-173.   DOI
27 Batzer, M. A. and P. L Deininger. 2002. Alu repeats and human genomic diversity. Nat. Rev. Genet. 3, 370-379.   DOI
28 Chimpanzee Sequencing and Analysis Consortium. 2005. Initial sequence of the chimpanzee genome and comparison with the human genome. Nature 437, 69-87.   DOI
29 Depil, S., C. Roche, P. Dussart, and L. Prin. 2002. Expression of a human endogenous retrovirus, HERV-K, in the blood cells of leukemia patients. Leukemia 16, 254-259.   DOI
30 Dunn, C. A., L. N. van de Lagemaat, G. J. Baillie, and D. L. Mager. 2005. Endogenous retrovirus long terminal repeats as ready-to-use mobile promoters: the case of primate beta3GAL-T5. Gene 364, 2-12.   DOI
31 Flint, J., J. Rochette, C. F. Craddock, C. Dod, B. Vignes, S. W. Horsley, L. Kearney, V. J. Buckle, H. Ayyub, and D. R. Higgs. 1996. Chromosomal stabilisation by a subtelomeric rearrangement involving two closely related Alu elements. Hum. Mol. Genet. 5, 1163-1169.   DOI
32 Gogvadze, E. and A. Buzdin. 2009. Retroelements and their impact on genome evolution and functioning. Cell Mol. Life Sci. 66, 3727-3742.   DOI