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http://dx.doi.org/10.5352/JLS.2011.21.2.316

Tryptophan Metabolite 3-Hydroxyanthranilic Acid Augments TRAIL-Induced Apoptosis in Activated T Cells  

Seo, Su-Kil (Department of Microbiology and Immunology, College of Medicine, Inje University)
Publication Information
Journal of Life Science / v.21, no.2, 2011 , pp. 316-321 More about this Journal
Abstract
Generation of tryptophan-derived metabolites by indoleamine 2,3-dioxygenase (IDO) is a potent immunoregulatory mechanism in T cell responses. However, the mechanism remains unclear. We showed that 3-hydroxyanthranilic acid (3-HAA), the most potent metabolite, selectively induced apoptosis in activated T cells, but not in resting T cells. This was not associated with cell cycle arrest. We found that TRAIL expression was selectively induced in activated T cells by treatment of 3-HAA. Blockade of the TRAIL: DR4/DR5 pathway significantly inhibited 3-HAA-mediated T cell death. Our data suggest that TRAIL-induced apoptosis is involved in the mechanism of 3-HAA-mediated T cell death.
Keywords
Indoleamine 2,3-dioxygenase; 3-hydroxyanthranilic acid; T cell; TNF-related apoptosisinducing ligand;
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