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http://dx.doi.org/10.5352/JLS.2011.21.2.165

Antidiabetic Synergistic Effects of Medicinal Plant Extract Mixtures on db/db Mice  

Roh, Sang-Geun (Department of Biology, College of Natural Sciences, Pusan National University)
Choi, Won-Chul (Department of Biology, College of Natural Sciences, Pusan National University)
Publication Information
Journal of Life Science / v.21, no.2, 2011 , pp. 165-175 More about this Journal
Abstract
This study investigates the effects of Psidium guajava L. leaf (Pg) extract, Lagerstroemia speciosa L. leaf (Ls) extract, and mixture A (Pg, Ls, Morus indica L. leaf, Pinus densiflora needles, Acanthopanax senticosus M. roots extract) on db/db mice. For four weeks, db/db mice were fed powdered extracts of Pg, Ls, and mixture A. Compared to the diabetic control, extracts of Pg, Ls and mixture A decreased body weight, glucose and insulin. The greatest decreases were caused by mixture A. These extracts decreased the levels of total cholesterol, triglyceride and free fatty acid compared to the diabetic control. The antihyperlipidemic effect of mixture A was the greatest. Mixture A also significantly decreased injuries of Langerhans' islets compared to the diabetic control. Mixture A showed a beneficial synergistic effect due to the supplementary pharmacological actions of the ingredients in contains, indicating that it improved hyperglycemia without the side effect of weight gain.
Keywords
db/db mice; hyperglycemia; synergistic effect;
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