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http://dx.doi.org/10.5352/JLS.2011.21.12.1789

Sarijang Enhances Maturation of Murine Bone Marrow-Derived Dendritic Cells  

Jin, Cheng-Yun (Department of Biomaterial Control (BK21 Program), Graduate School)
Han, Min-Ho (Department of Biomaterial Control (BK21 Program), Graduate School)
Park, Cheol (Department of Biochemistry, College of Oriental Medicine)
Hwang, Hye-Jin (Department of Food and Nutrition, College of Human Ecology)
Choi, Eun-A (InSan BamBoo Salt Inc.)
Choi, Yung-Hyun (Department of Biomaterial Control (BK21 Program), Graduate School)
Publication Information
Journal of Life Science / v.21, no.12, 2011 , pp. 1789-1794 More about this Journal
Abstract
Dendritic cells (DCs) are professional antigen-presenting cells playing key roles in immune sentinels as initiators of T-cell responses against microbial pathogens and tumors. Sarijang, a folk sauce containing extracts of Rhynchosia nulubilis, Ulmus davidiana roots, Allium sativum, and Rhus Verniaiflura bark, has been used as a nonspecific immunostimulant for cancer patients. However, little is known about its immunomodulating effects or their mechanisms. In this study, we investigated whether sarijang induces phenotypic and functional maturation of DCs. For this study, murine bone marrow-derived myeloid DCs were cultured in the presence of interleukin-4 (IL-4) and granulocyte-macrophage colony stimulating factor (GM-CSF), and the generated immature DCs were stimulated with sarijang or lipopolysaccharide (LPS). Our data indicated that sarijang significantly enhanced the expression of co-stimulatory molecules (CD80 and CD86) as well as major histocompatibility complex (MHC) II, as did LPS. The results provide new insight into the immunopharmacology of sarijang and suggest a novel approach to the manipulation of DC for therapeutic application.
Keywords
Sarijang; dendritic cells; maturation;
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