Browse > Article
http://dx.doi.org/10.5352/JLS.2010.20.9.1385

Ingredients Analysis and Biological Activity of Fermented Angelica gigas Nakai by Mold  

Cha, Jae-Young (Technical Research Institute, Daesun Distilling Co., Ltd.)
Kim, Hyun-Woo (Technical Research Institute, Daesun Distilling Co., Ltd.)
Heo, Jin-Sun (Sancheong Institute of Medicinal Herb on Foundation)
Ahn, Hee-Young (Department of Biosciences, Graduate School, Dong-A University)
Eom, Kyung-Eun (Department of Biosciences, Graduate School, Dong-A University)
Heo, Su-Jin (Department of Biosciences, Graduate School, Dong-A University)
Cho, Young-Su (Department of Biotechnology, Dong-A University)
Publication Information
Journal of Life Science / v.20, no.9, 2010 , pp. 1385-1393 More about this Journal
Abstract
Three mold strains, Aspergillus oryzae (AOFAG), Aspergillus kawachii (AKFAG), and Monascus purpureus (MPFAG) were used for fermentation of Angelica gigas Nakai powder. The contents of polyphenolic compounds, flavonoids, minerals, decursin and decursinol angelate and the activities of DPPH (${\alpha},{\alpha}-diphenyl-$\beta$-picrylhydrazyl) free radical scavenging, reducing power, and tyrosinase were measured. The highest contents of phenolic compound and flavonoid were NFAG at 2.78% and MPFAG at 1.18%, respectively. Major minerals were K, Mg, Fe, Na and Ca. Decursin and decursinol angelate were the major ingredients of Angelica gigas according to HPLC analysis. Decursin area was higher in all fermented Angelica gigas than in NFAG. The activities of free radical scavenging and tyrosinase were stronger in all fermented Angelica gigas than NFAG. However, the Fe/Cu reducing powers were stronger in NFAG than all fermented Angelica gigas. Overall, these results may provide the basic data needed to understand the biological activities and chemical characteristics of Angelica gigas fermented by mold for the development of functional foods.
Keywords
Fermented-Angelica gigas Nakai; decursin; decursinol angelate; antioxidation; tyrosinase;
Citations & Related Records
Times Cited By KSCI : 23  (Citation Analysis)
연도 인용수 순위
1 Seong, N. S., S. W. Lee, K. S. Kim, and S. T. Lee. 1993. Environmental variation of decursin content in Angelica gigas. Korean J. Crop Sci. 38, 60-65.   과학기술학회마을
2 Shon, M. E. 2007. Antioxidant and anticancer activities of Poria cocos and Machilus thunbergii fermented with mycelial mushrooms. Food Indus. Nutr. 12, 51-57.   과학기술학회마을
3 Son, J. W., H. J. Kim, and D. K. Oh. 2008. Ginsenoside Rd production from the major ginsenoside Rb(1) by beta-glucosidase from Thermus caldophilus. Biotechnol. Lett. 30, 713-716.   DOI
4 Swain, T., W. E. Hillis, and M. Oritega. 1959. Phenolic constituents of Ptunus domestica. I. Quantitative analysis of phenolic constituents. J. Sci. Food Agric. 10, 83-88.
5 Vile, G. F. and R. M. Tyrrell. 1995. UVA radiation-induced oxidative damage to lipid and protein in vitro and in human skin fibroblast is dependent on iron and singlet oxygen. Free Radical Biol. Med. 18, 721-730.   DOI
6 Woo, K. S., I. G. Hwang, D. S. Song, Y. R. Lee, J. S. Lee, and H. S. Jeong. 2008. Changes in antioxidant activity of Rehmannia radix Libosch with heat treatment. Food Sci. Biotechnol. 17, 1387-1390.
7 Yang, H. J., E. H. Kim, J. O. Park, J. E. Kim, and S. N. Park. 2009. Antioxidative activity and component analysis of fermented Melissa officinalis extracts. J. Soc. Cosmet. Scientists Korea 35, 47-55.
8 Yang, H. J., E. H. Kim, J. O. Park, J. E. Kim, and S. N. Park. 2009. Antioxidant activity and component analysis of fermented Melissa officinalis extracts. J. Soc. Cosmet. Scientists Korea 35, 125-134.
9 Masamoto, Y., H. Ando, Y. Murata, Y. Shimoishi, M. Tada, and K. Takahata. 2003. Mushroom tyrosinase inhibitory activity of esculetin isolated from seeds of Euphorbia lathyris L. Biosci. Biotechnol. Biochem. 67, 631-634.   DOI
10 Maxson, E. and L. Rooney. 1972. Evaluation of methods for tannin analysis in sorghum grain. Cereal Chem. 49, 719-729.
11 Cha, J. Y., H. Y. Ahn, K. E. Eom, B. K. Park, B. S. Jun, J. C. Park, C. H. Lee, and Y. S. Cho. 2009. Effects of Monascus-fermented Korean red ginseng powder on the contents of serum lipid and tissue lipid peroxidation in alcohol feeding rats. J. Life Sci. 19, 983-993.   DOI
12 Cha, J. Y., Y. S. Kim, P. D. Kang, H. Y. Ahn, K. E. Eom, and Y. S. Cho. 2010. Biological activity and chemical characteristics of fermented silkworm powder by mold. J. Life Sci. 20, 237-244.   DOI
13 Cha, J. Y., H. J. Yang, J. J. Jeong, W. S. Seo, J. S. Park, M. Ok, and Y. S. Cho. 2010. Tyrosinase inhibition activity and antioxidant capacity by fermented products of some medicinal plants. J. Life Sci. 20, 940-947.   DOI
14 Choi, Y. M., J. B. Gu, M. H. Kim, and J. S. Lee. 2008. Antioxidant and antiproliferative activities of methanolic extracts from thirty Korean medicinal plants. Food Sci. Biotechnol. 17, 1235-1239.   과학기술학회마을
15 Duncan, D. B. 1959. Multiple range and multiple F test. Biometrics 1, 1-42.   DOI
16 Han, G. J., D. S. Shin, and M. S. Jang. 2008. A study of the nutritional composition of Aralica continentalis Kitagawa and Aralica continentalis Kitagawa leaf. Korean J. Food Sci. Technol. 40, 680-685.
17 Hong, M. W. 1972. Statistical studies on the formularies of oriental medicine (I) prescription frequency and their origin distribution of herb drugs. Korean J. Pharmacog. 3, 57-64.
18 Oh, S. L., S. S. Kim, B. Y. Min, and D. H. Chung. 1990. Composition of free sugars, free amino acids, non-volatile organic acids and tannins in the extracts of L. chinensis M., A. acutiloba K., S. chinesis B. and A. sessiliflorum S. Korean J. Food Sci. Technol. 22, 76-81.
19 Zhu, Q. V., R. M. Hackman, X. X. Jodilensunsa, R. R. Holt, and C. L. Keen. 2002. Antioxidative activities of Oolong tea. J. Agric. Food Chem. 50, 6229-6934.
20 Oh, S. H., Y. S. Cha, and D. S. Choi. 1999. Effects of Angelica gigas Nakai diet on lipid metabolism, alcohol metabolism and liver function of rats administered with chronic ethanol. J. Korean Soc. Agric. Chem. Biotechnol. 42, 29-33.
21 Park, J. C., J. Y. Cha, C. H. Lee, E. S. Doh, I. K. Kang, and Y. S. Cho. 2009. Biological activities and chemical characteristics of Monascus-fermented Korea red ginseng. J. Life Sci. 19, 1553-1561.   DOI
22 Park, K. W., S. R. Choi, M. E. Shon, I. Y. Jeong, K. S. Kang, S. T. Lee, K. H. Shim, and K. I. Seo. 2007. Cytotoxic effects of decursin from Angelica gigas Nakai in human cancer cells. J. Korean Soc. Food Sci. Nutr. 36, 1385-1390.   DOI
23 Park, S. J., S. W. Song, D. H. Seong, D. S. Park, S. S. Kim, J. Gou, J. H. Ahn, W. B. Yoon, and H. Y. Lee. 2009. Biological activities in the extract if fermented Codonopsis lanceolata. J. Korean Soc. Food Sci. Nutr. 38, 983-988.   DOI
24 Park, S. S., Y. B. Ryu, Y. H. Lee, Y. U. Cho, S. J. Cho, Y. J. Choi, K. H. Park, and S. W. Gal. 2007. Inhibition of melanin synthesis by mycelial culture broth of Paecilomyces japonica in the mulberry leaf extract. J. Life Sci. 17, 816-821.   DOI
25 Pyo, Y. H. 2007. Comparison of antioxidant potentials in methanolic extracts from soybean and rice fermented with Monascus sp. Food Sci. Biotechnol. 16, 451-456.   과학기술학회마을
26 Ahn, M. J., M. K. Lee, Y. C. Kim, and S. H. Sung. 2008. The simultaneous determination of coumarins in Angelica gigas root by high performance liquid chromatography-diode array detector coupled with electrospray ionization/ mass spectrometry. J. Pharm. Biomed. Anal. 46, 258-266.   DOI
27 Hwang, J. B. and M. O. Yang. 1997. Comparison of chemical components of Angelica gigas Nakai and Angelica acutiloba Kitagawa. Korean J. Food Sci. Technol. 29, 1113-1118.
28 Jee, S. O. 2009. Antioxidant activities and whitening effect of the mulberry (Morus alba L.) root bark extracts. Korean J. Plant Res. 22, 145-151.
29 Abe, N., T. Murata, and A. Hirota. 1998. Novel DPPH radical scavengers, bisorbicillinol and demethyltrichodimerol, from a fungus. Biosci. Biotechnol. Biochem. 62, 661-666.   DOI
30 Ahn, Y. J., B. R. Won, M. K. Kang, J. H. Kim, and S. N. Park. 2009. Antioxidant activity and component analysis of fermented Lavamdula angustifolia extracts. J. Soc. Cosmet. Scientists Korea 35, 125-134.
31 Kim, C. H., M. C. Kwon, H. G. Han, C. S. Na, H. G. Kwak, G. P. Choi, U. Y. Park, and H. Y. Lee. 2008. Skin-whitening and UV-protective effects of Angelica gigas Nakai extracts on ultra high pressure extraction process. Korean J. Medicinal Crop Sci. 16, 255-260.
32 Ryu, K. S., N, D, Hong, and Y. Y. Kim. 1990. Studies on the coumarin constituents of the root of Angelica gigas Nakai. Isolation of decursinol angelate and assay of decursinol angelate and decursin. Korean J. Pharmacogn. 21, 64-68.   과학기술학회마을
33 Jia, Z., M. Tang, and J. Wu. 1999. The determination of flavonoid contents in mulberry and thier scavenging effects on superoxide radicals. Food Chem. 64, 555-559.   DOI
34 Jung, S. W., N. K. Lee, S. J. Kim, and D. S. Han. 1995. Screening of tyrosinase inhibitor from plants. Korean J. Food Sci. Technol. 27, 891-896.
35 Kim, E. Y., I. H. Baik, J. H. Kim, S. R. Kim, and M. R. Rhyu. 2004. Screening of the antioxidant activity of some medicinal plants. Korean J. Food Sci. Technol. 36, 333-338.
36 Kim, H. S. and S. W. Joung. 2006. Effective components and nitrile scavenging ability of root and leaves a Angelica gigas Nakai. Korean J. Food Cookery Sci. 22, 957-965.
37 Kim, K. M., J. Y. Jung, S. W. Hwang, M. J. Kim, and J. S. Kang. 2009. Isolation and purification of decursin and decursinol angelate in Angelica gigas Nakai. J. Korean Soc. Food Sci. Nutr. 38, 653-656.   DOI   ScienceOn
38 Lee, J. H. and S. R. Lee. 1994. Analysis of phenolic substances content on Korea plant foods. Korean J. Food Sci. Technol. 26, 310-316.
39 Lee, J. J., A. R. Kim, Y. N. Seo, and M. Y. Lee. 2009. Comparison of physicochemical composition of three species of genus Angelica. Korean J. Food Preserv. 16, 94-100.
40 Cabanes, J., S. Chazarra, and F. Garcia-Carmona. 1994. Kojic acid, a cosmetic skin whitening agent, is a slow binding inhibitor of catecholase activity of tyrosinase. J. Pharm. Pharmacol. 46, 982-985.   DOI   ScienceOn
41 Cha, J. Y., H. J. Kim, C. H. Chung, and Y. S. Cho. 1999. Antioxidative activities and contents of polyphenolic compound of Cudrania tricuspidata. J. Korean Soc. Food Sci. Nutr. 28, 1310-1315.   과학기술학회마을