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http://dx.doi.org/10.5352/JLS.2010.20.7.1143

Antibacterial Activity of Oriental Medicinal Herb Extracts against Skin Pathogens  

Yu, Young-Eun (The Research Center for Biomedical Resources of Oriental Medicine, Daegu Haany University)
Park, Eun-Young (The Research Center for Biomedical Resources of Oriental Medicine, Daegu Haany University)
Jung, Dae-Hwa (The Research Center for Biomedical Resources of Oriental Medicine, Daegu Haany University)
Byun, Sung-Hui (College of Oriental Medicine, Daegu Haany University)
Kim, Sang-Chan (The Research Center for Biomedical Resources of Oriental Medicine, Daegu Haany University)
Park, Sung-Min (The Research Center for Biomedical Resources of Oriental Medicine, Daegu Haany University)
Publication Information
Journal of Life Science / v.20, no.7, 2010 , pp. 1143-1150 More about this Journal
Abstract
The antibacterial activity of methanol extracts from 70 kinds of oriental medicinal herbs on four strains of Staphylococcus aureus and S. epidermidis was investigated. The results showed that C. japonica, C. sappan, R. javanica, R. tanguticum, and S. miltiorrhiza had an antibacterial activity on all the strains used. Among these, C. japonica and R. javanica, which showed excellent antibacterial activity, were extracted with water, ethanol, methanol, and ethyl acetate for further study of antibacterial activities. The results showed that the boiled water extract of C. japonica had the best antibacterial activity. Assuming that the antibacterial activity of C. japonica originated from berberine, which has been reported many times, the berberine content of the boiled water extract of C. japonica was analyzed and the result was 13.88%. To compare the antibacterial activity of berberine with that of other antibiotics, berberine chloride and three other kinds of antibiotics were investigated, which showed that berberine chloride had an antibacterial activity on KCCM 35494 S. epidermidis only when the concentration was higher than 600 mg/l, and it did not show antibacterial activity in the other strains. Based on these results, it was concluded that the antibacterial activity of the boiled water extract of C. japonica on the strains used in this study originated from high concentration of berberine or substances other than berberine. Therefore, identification of the substance will be necessary.
Keywords
Skin pathogen; oriental medicinal herb; antibacterial activity;
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