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http://dx.doi.org/10.5352/JLS.2010.20.7.1078

Residual Consistency and Interrelationship Estimation of PCDDs, PCDFs, Dioxin-like PCBs in Colostrum of Primipara and Multipara  

We, Sung-Ug (Department of Environmental Engineering, Kyungnam University)
Kim, Ki-Ho (Center for Instrumental Analysis, Kyungnam University)
Cho, Yu-Jin (Department of Environmental Engineering, Kyungnam University)
Cho, Bong-Hui (Department of Environmental Engineering, Kyungnam University)
Park, Sang-Ah (Department of Environmental Engineering, Kyungnam University)
Baek, In-Cheon (Department of Environmental Engineering, Kyungnam University)
Kang, Seong-Hoon (Department of Environmental Engineering, Kyungnam University)
Yoon, Cho-Hee (Department of Environmental Engineering, Kyungnam University)
Min, Byung-Yoon (Department of Environmental Engineering, Kyungnam University)
Publication Information
Journal of Life Science / v.20, no.7, 2010 , pp. 1078-1085 More about this Journal
Abstract
Polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs) and dioxin-like polychlorinated biphenyls (dl-PCBs) are bioaccumulative chemicals that are considered to be toxic contaminants based on several epidemiological studies. These chemicals in colostrum were investigated and estimated for their residual consistencies by maternal characteristics like parity and maternal ages. Test subjects were healthy primipara and multipara mothers with a mean age of 31.5 (S.D=3.6) in 2007. Seven isomers of PCDDs, 10 of PCDFs, 4 of non-orthopolychlorinated biphenyls(non-ortho PCBs) and 8 of mono-orthochlorinated polychlorinated biphenyls (mono-ortho PCBs) were analyzed by HRGC/HRMS. From the analyzed data, the mean level of total WHO-TEQs was 9.41 pg TEQ/g lipid, which is significantly lower than the level found in individuals from other countries. The main contributors to the total WHO-TEQs with increasing percentages were 2,3,4,7,8-PeCDF, 1,2,3,7,8-PeCDD and 3,3',4,4',5-PCB (#126), and they accounted for more than 60% of the total WHO-TEQs. PCDFs concentrations and total WHO-TEQs were negatively associated with parity (p<0.05), and maternal age was positively associated with total WHO-TEQs (p<0.01). However, the associations with body mass index (BMI) and fish intake during pregnancy were not significant. These results were suggested that parity and maternal age are an important factor affecting the concentrations of PCDD/DFs and dl-PCBs in these specimens.
Keywords
Polychlorinated dibenzo-p-dioxins (PCDDs); polychlorinated dibenzofurans (PCDFs); dioxin-like PCBs; TEQs; congener profiles; colostrum;
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