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http://dx.doi.org/10.5352/JLS.2010.20.6.825

A Study on the Prolactin Receptor 3 (PRLR3) Gene and the Retinol-binding Protein 4 (RBP4) Gene as Candidate Genes for Growth and Litter Size Traits of Berkshire in Korea  

Do, Chang-Hee (Department of Animal Biosystem Science, Chungnam National University)
Kim, Seon-Ku (Department of Animal Science, Pusan National University)
Kang, Han-Suk (Department of Animal Science, Pusan National University)
Shin, Teak-Soon (Department of Animal Science, Pusan National University)
Lee, Hong-Gu (Department of Animal Science, Pusan National University)
Cho, Seong-Keun (Department of Animal Science, Pusan National University)
Do, Kyung-Tak (Department of Animal Science, Pusan National University)
Song, Ji-Na (Department of Animal Science, Pusan National University)
Kim, Tae-Hun (Animal Genomics and Bioinformatics Division, National Livestock Research Institute, RDA)
Choi, Bong-Hwan (Animal Genomics and Bioinformatics Division, National Livestock Research Institute, RDA)
Sang, Byung-Chan (Department of Animal Biosystem Science, Chungnam National University)
Joo, Yeong-Kuk (Gyeongnam Livestock Veterinary Research Institute)
Park, Jun-Kyu (Gyeongnam Livestock Veterinary Research Institute)
Lee, Sung-Hoon (Gyeongnam Livestock Veterinary Research Institute)
Lee, Jeong-Ill (Gyeongnam Livestock Veterinary Research Institute)
Park, Jeong-Suk (Gyeongnam Livestock Veterinary Research Institute)
Sin, Young-Soo (Department of Animal Science, Shingu University)
Kim, Byung-Woo (Institute of Agriculture & Life Sciences, Gyeongsang University)
Cho, Byung-Wook (Department of Animal Science, Pusan National University)
Publication Information
Journal of Life Science / v.20, no.6, 2010 , pp. 825-830 More about this Journal
Abstract
Two diallelic markers at candidate gene loci, the prolactin receptor 3 (PRLR3) gene and the retinol-binding protein 4 (RBP4) gene were evaluated for their association with growth and litter size traits in Berkshire. Genetic evaluation was conducted for 5,919 pigs with pedigree information, which included 3,480 growth performance records and 775 litter size records of 224 sows. From the same herd, genotyping was carried out on 144 and 156 animals for PRLR3 and RBP4, respectively. After assigning a genotype to subjects in which both parents had a homozygous genotype, numbers of genotyped animals increased to 474 and 338, for the PRLR3 gene and RBP4 gene, respectively. The genotype effects of two markers were estimated with breeding values of the genotyped animals. The additive effects of total number of piglets born and number of piglets born alive in the PRLR3 locus were -0.28 and -0.13, respectively. The dominance effect of the RBP4 locus on average daily gain was -10.58 g. However, the polymorphism of the RBP4 locus in total number of piglets born and number of piglets born alive has shown -0.34 and -0.33 of the additive genetic effects. In view of the results, MAS (marker-assisted selection) favoring B alleles of RBP4 and PRLR3 loci could potentially accelerate the rate of the genetic improvement in the litter size traits.
Keywords
Berkshire; prolactin receptor 3 (PRLR3); retinol-binding protein 4 (RBP4); additive effect; marker-assisted selection;
Citations & Related Records
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1 Pope, W. F. 1994. Embryonic mortality in swine, pp. 53-57, In Zavy, M. T. and R. D. Geisert (eds.), Embryonic Mortality in Domestic Species. CRC Press, Boca Raton.
2 Brief, S. and B. P. Chew. 1985. Effects of vitamin A and ${\beta}$-carotene on reproductive performance in gilts. J. Anim. Sci. 60, 998-1004.
3 Do, C. H. 2007. Estimation of growth traits using growth curve in Gyungnam-heugdon (Berkshire). J. Anim. Sci. & Technol. (Kor.) 49, 195-202.   과학기술학회마을   DOI
4 Drogemuller, C., H. Hamann, and O. Distl. 2001. Candidate gene markers for litter size in different German pig lines. J. Anim. Sci. 79, 2565-2570.
5 Du, F., A. C. Clutter, and M. M. Lohuis. 2007. Characterizing Linkage Disequilibrium in Pig Populations Int. J. Biol. Sci. 3, 166-178.
6 Falconer, D. S. 1981. Introduction to Quantitative Genetics. pp. 18-20, Longman Scientific and Technical.
7 Fujii, J., K. Otus, F. Zorzto, S. ED Leon, V. K. Khanna, V. K., Weiler, P. J. O’Brien, and D. H. MacLennan. 1991. Identification of a mutation in porcine ryanodine receptor associated with malignant hyperthermia. Sci. 253, 448-451.   DOI
8 Gerbens, F., A. J. van Erp, F. L. Harders, F. J. Verburg, T. H. Meuwissen, J. H. Veerkamp, and M. F. te Pas. 1999. Effect of genetic variants of the heart fatty acid-binding protein gene on intramuscular fat and performance traits in pigs. J. Anim. Sci. 77, 846-852.
9 Harney, J. P., T. L. Ott, R. D. Geisert, and F. W. Bazer. 1993. Retinolbinding protein gene expression in cyclic and pregnant endometrium of pigs, sheep, and cattle. Biol. Reprod. 49, 1066-1073.   DOI
10 Rothschild, M. F. 1998. Identification of quantitative trait loci and interesting candidate genes in the pig: Progress and prospects. Proceeding of 6th World Congress on Genetic Application of the Livestock Production, Armidale, NSW, Australia. 26, 403-409.
11 Rothschild, M. F., L. Messer, A. Day, R. Wales, T. Short, O. Southwood, and G. Plastow. 2000. Investigation of the retinol-binding protein 4 (RBP4) gene as a candidate gene for increased litter size in pigs. Mamm. Genome 11, 75-77.   DOI
12 Santos-Guzman, J., T. Arnhold, H. Nau, C. Wagner, S. H. Fahr, G. E. Mao, M. A. Caudill, J. C. Wang, S. M. Henning, M. E. Swendseid, and M. D. Collins. 2003. Antagonism of hypervitaminosis; An induced anterior neural tube closure defects with a methyl-donor deficiency in murine wholeembryo culture. J. Nutr. 133, 3561-3570.
13 Short, T. H., M. F. Rothschild, O. I. Southwood, D. G. McLaren, A. de Vries, H van der Steen, G. R. Steen, G. R. Eckhardt, C. K. Tuggle, J. Helm, and D. A. Vaske. 2006. MTGSAM and MTDFREML. http://www.aipl.arsusda.gov/curtvt/.
14 Varona, L., D. Sorensen, and R. Thompson. 2007. Analysis of Litter Size and Average Litter Weight in Pigs Using a Recursive Model. Genetics 177, 1791-1799.   DOI
15 Vincent, A. L., G. Evans, T. H. Short, O. I. Southwood, G. S. Plastow, C. K. Tuggle, and M. F. Rothschild. 1998. The prolactin receptor gene is associated with increased litter size in pigs. Proceeding of 6th World Congress on Genetic Application of the Livestock Production, Armidale, NSW, Australia. 27, 15-18.
16 Zhu, M. and S. Zhao. 2007. Candidate Gene Identification Approach: Progress and Challenges. Int. J. Biol. Sci. 3, 420-427.
17 Mileham, J. and G. S. Plastow. 1997. Effect of the estrogen receptor locus on reproduction and production traits in four commercial pig lines. J. Anim. Sci. 75, 3138-3142.
18 Henderson, C. R. 1973. Sire evaluation and genetic trends. Proceeding of the Animal Breeding and Genetics Symposium in honor of Dr. Jay L. Lush. July 29, 1972, Virginia Polytechnic Institute and State University, Blacksburg, Virginia.
19 Isler, B. J., K. M. Ervin, M. F. Rothchild, and G. J. Evans. 2000. Association between the prolactine receptorgene and reproductive components in swine. Proceeding of the 27th International Conference on Animal Genetics, 27, pp. 67, Minneapolis, Etats-Unis.
20 Kim, K. S., N. Larsen, T. Short, G. Plastow, and M. F. Rothschild. 2000. A missense variant of the porcine melanocortin-4 receptor (MC4R) gene is associated with fatness, growth, and feed intake traits. Mann. Genome. 149, 1069-1080.