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http://dx.doi.org/10.5352/JLS.2010.20.5.768

Nitrite Scavenging and Alcohol Metabolizing Activities of Hot Water Extract from Makgeoly and Its Angiotensin Converting Enzyme Inhibitory Effect  

Cho, Eun-Kyung (Department of Bio-Food Materials, College of Medical Life Science, Silla University)
Kim, Hee-Yeon (Department of Food and Nutrition, College of Medical Life Sciences, Silla University)
Byeon, Hyeon-Ji (Department of Food and Nutrition, College of Medical Life Sciences, Silla University)
Kim, Soo-Won (NzonB&F)
Choi, Young-Ju (Department of Food and Nutrition, College of Medical Life Sciences, Silla University)
Publication Information
Journal of Life Science / v.20, no.5, 2010 , pp. 768-774 More about this Journal
Abstract
In this study, we investigated the antioxidant activities, alcohol metabolizing activities, nitrite scavenging ability, angiotensin converting enzyme (ACE), and elastase inhibitory effects of hot water extract from Makgeoly (HWM). Antioxidant activities were measured by using 2,2.diphenyl.1.picryl.hydrazyl (DPPH) free radical scavenging activity and SOD (superoxide dismutase).like activity. The DPPH radical scavenging activity and SOD.like activity of HWM were remarkably increased in a dose.dependent manner and were 48.0% and 98.7% at 10 mg/ml, respectively. To determine the influence of HWM on alcohol metabolizing activity, the generating activities of reduced.nicotinamide adenine dinucleotide (NADH) by alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) were measured. The facilitating rates of ADH and ALDH activity by HWM were remarkably increased in a dose.dependent manner and were 70.2% and 64.1% at 10 mg/ml, respectively. The inhibitory activity against angiotensin converting enzyme (ACE) of HWM was increased in a dose.dependent manner and was 74.2% at 10 mg/ml. The nitrite scavenging ability of HWM showed the most remarkable effect at pH 1.2 and 2 mg/ml. These results indicated that HWM may have valuable biological properties owing to their antioxidant activities, ADH and ALDH activity, nitrite scavenging ability, and ACE inhibitory activity.
Keywords
Makgeoly; antioxidant activities; alcohol metabolizing activities; nitrite scavening activity; angiotensin converting enzyme;
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Times Cited By KSCI : 17  (Citation Analysis)
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1 Blois, M. S. 1958. Antioxidant determination by the use of a stable free radical. Nature 26, 1198-1200.
2 Choi, J. T., H. K. Joo, and S. K. Lee. 1995. The effect of Schizandrae fructus extract on alcohol fermentation and enzyme activities of Saccharomyces cerevisiae. Agric. Chem. Biotechnol. 38, 278-282.
3 Cushman, D. W. and H. S. Cheung. 1971. Spectrophotometric assay and properties of the angiotensin-converting enzyme of rabbit lung. Biochem. Pharmacol. 20, 1637-1648.   DOI
4 Shin, M. O., D. Y. Kang, M. H. Kim, and S. J. Bae. 2008. Effect of growth inhibition and quinone reductase activity stimulation of Makgeoly fractions in various cancer cells. J. Korean Soc. Food Sci. Nutr. 37, 288-293.   과학기술학회마을   DOI
5 Saito, Y., K. Wanezaki, A. Kawato, and S. Imayasu. 1994b. Structure and activity of angiotensine I converting enzyme inhibitory peptides from sake and sake lees. Biosci. Biotechnol. Biochem 58, 1767-1771.   DOI
6 Tottmar, S. O., H. Petterson, and K. H. Kiessling 1973. The subcellular distribution and properties of aldehyde dehydrogenase in rat liver. Biochem. J. 135. 577-581.
7 Yoo, T. J. 1981. Korean famous wine. pp. 96, Central New Book, Seoul, Korea.
8 Park, Y. B., T. G. Lee, O. K. Kim, J. R. Do, S. G. Yeo, Y. H. Park, and S. B. Kim. 1995. Characteristics of nitrite scavenger derived from seeds of Cassia tora L. Korean J. Food Sci. Technol. 27, 124-128.   과학기술학회마을
9 Racker, E. 1973. Alcohol dehydrogenase in rat liver. Biochem. J. 135, 577-581.
10 Saito, Y, K. Wanezaki, A. Kawato, and S. Imayasu. 1994a. Antihypertensive effects of peptide in sake and its by-products on spontaneously hypertensive rats. Biosci. Biotechnol. Biochem. 58, 812-816.   DOI
11 Moon, J. S., S. J. Kim, Y. M. Park, I. S. Hwang, E. H. Kim, J. W. Park, I. B. Park, S. W. Kim, S. G. Kang, Y. K. Park, and S. T. Jung. 2004. Activities of antioxidation and alcohol dehydrogenase inhibition of methanol extracts from some medicinal herbs. Korean J. Food Preserv. 11, 201-206.   과학기술학회마을
12 Lee, Y. S., E. Y. Joo, and N. W. Kim. 2005. Antioxidant activity of extracts from the Lespedeza bicolor. Korean J. Food Preserv. 12, 75-79.   과학기술학회마을
13 Nanji, A. A. and D. Zakim. 1996. Alcoholic liver disease. In Hepatology 3rd ed., Zakim D, Boyer T (eds.). Saunders, Philadelphia, 3, 891-936.
14 Lim, J. D., C. Y. Yu, M. J. Kim, S. J. Yun, S. J. Lee, N. Kim, and I. M. Chung. 2004. Comparison of SOD activity and phenolic compound contents in various Korean medicinal plant. Korean J. Med. Crop Sci. 12, 191-202.
15 Marklund, S. and G. Marklund. 1975. Involvement of superoxide aminoradical in the oxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur. J. Biochem. 47, 468-474.
16 Maruyama, S., K. Nakagomi, N. Tomizuka, and H. Suzuki. 1985. Angiotensin converting enzyme inhibitor derived from an enzymatic hydrolysate of casein. Agric. Biol. Chem. 49, 1405-1410.   DOI
17 Lee, H. S., K. H. Hong, C. H. Yoon, J. M. Kim, and S. M. Kim. 2009. Effect of Korean turbid rice wine (Takju) lees extract on blood glucose level in db/db mouse. Korean J. Food Culture 24, 219-223.   과학기술학회마을
18 Lee, J. S, T. S. Lee, S. O. Park, and B. S. Noh. 1996. Flavor components in mash of Takju prepared by different raw materials. Korean J. Food Sci. Technol. 28, 316-323.   과학기술학회마을
19 Lee, S. H. and J. S. Joo. 1985. Nutritional influence of Takju (Korean rice wine) on human body. J. Ko Rae Univ. 22, 17-32.
20 Kim, S. M. and W. K. Cho, 2006. Effect of Takju (Korean turbid rice wine) lees on the serum glucose levels in Streptozotocin-induced diabetic rats. Korean J. Food Culture 21, 638-643.
21 Lee, H. S., K. H. Hong, J. Y. Kim, D. H. Kim, C. H. Yoon, and S. M. Kim. 2009. Blood pressure lowering effect of Korean turbid rice wine (Takju) lees extracts in spontaneously Hypertensive Rat (SHR). Korean J. Food Culture 24, 338-343.   과학기술학회마을
22 Jin, J. S. Y. Kim, Q. Jin, H. J. Eom, and N. S. Han. 2008. Diversity analysis of lactic acid bacteria in Takju, Korean rice wine. J. Microbial. Biotechnol. 18, 1678-1682.   과학기술학회마을
23 Kim, M. H., Y. T. Chung, J. H. Lee, Y. S. Park., M. K. Shin, H. S. Kim, D. H. Kim, and H. Y. Lee. 2000. Hepatic detoxification activity and reduction of serum alcohol concentration of Hovenia dulcis THUNB from Korea and China. Korean J. Medicinal Crop Sci. 8, 225-233.   과학기술학회마을
24 Kim, N. M., J. W. Lee, J. H. Do, and J. W. Yang. 2003. Effects of the fermentation periods on the qualities and functionalities of the fermentation broth of wild vegetables. Kor. J. Food Sci. Technol. 35, 272-279.   과학기술학회마을
25 Kim, A. R., S. Y. Lee, K. B. W. R Kim, E. J. Song, J. H. Kim, M. J. Kim, K. W. Ji, and I. S. Ahn, and D. H. Ahn. 2008. Effect of Glycyrrhiza uralensis on shelf-life and quality of Takju. Korean J. Food Sci. Technol 40, 194-200.   과학기술학회마을
26 Kim, J. E., S. K. Jung, S. J. Lee, K. W. Lee, G. W. Kim, and H. J. Lee. 2008. Nuruk extract inhibits lipopolysaccharideinduced production of nitrite and interleukin-6 in RAW 264.7 cells through blocking activation of p38 mitogen- activated protein kinase. J. Microbial. Biotechnol. 18, 1423-1426.   과학기술학회마을
27 Hong, H. D., N. K. Kang, and S. S. Kim. 1998. Superoxide dismutase-like activity of apple juice mixed with some fruits and vegetable. Korean J. Food Sci. Technol. 30, 1484-1487.   과학기술학회마을
28 Hwang, J. Y, J. W. Ham, and S. H. Nam. 2004. Effect of Maesil (Prunus mume) juice on the alcohol metabolizing enzyme activities. Korean J. Food Sci. Technol. 36, 329-332.   과학기술학회마을
29 Jeong, J. W., K. J. Park, M. H. Kim, and D. S. Kim. 2006. Changes in quality of spray-dried and freeze-dried Takju powder during storage. Korean J. Food Sci. Technol. 38, 513-520.   과학기술학회마을
30 Edaily EFN, 2008.6.23. http://efn.edail.co.kr/BrandNews/pop_print.asp.
31 Gray, J. I. and L. R. Dugan Jr. 1975. Inhibition of N-nitrosamine formation in model food systems. J. Food Sci. 40, 981-984.   DOI