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http://dx.doi.org/10.5352/JLS.2010.20.4.618

The Relationship between the Urinary Arsenic and 8-Hydroxydeoxyguanosine Levels in Women of Abandoned Mine Area  

Choi, Young-Sook (Department of Preventive Medicine, Medical Research Institute & College of Medicine, Chungbuk National University)
Eom, Sang-Yong (Department of Preventive Medicine, Medical Research Institute & College of Medicine, Chungbuk National University)
Choi, Byoung-Sun (Department of Preventive Medicine, College of Medicine, Chungang University)
Park, Jung-Duk (Department of Preventive Medicine, College of Medicine, Chungang University)
Kim, Yong-Dae (Department of Preventive Medicine, Medical Research Institute & College of Medicine, Chungbuk National University)
Kim, Heon (Department of Preventive Medicine, Medical Research Institute & College of Medicine, Chungbuk National University)
Publication Information
Journal of Life Science / v.20, no.4, 2010 , pp. 618-622 More about this Journal
Abstract
This study examines the relationship between urinary arsenic concentration and urinary 8-hydroxydeoxyguanosine (8-OHdG) concentrations, an index of oxidative DNA damage, among women who live near abandoned metal mines. The sample consisted of 165 residents living near two abandoned metal mines located in Chungbuk Province. Demographic characteristics as well as environmental factors relevant to arsenic exposure were collected through interviews, and urinary arsenic concentrations and urinary 8-OHdG concentrations of the research subjects were measured. The collected data were subsequently analyzed using the statistics program SPSS 12.0. The geometric average of urinary arsenic concentrations among the research subjects was $5.65\;{\mu}g/g$ creatinine. In a correlation analysis between urinary arsenic and 8-OHdG concentrations, the correlation coefficient was significant (p<0.001) at 0.399. This study suggests that urinary 8-OHdG concentrations may be a DNA damage marker for chronic arsenic exposure in women.
Keywords
Arsenics; 8-hydroxydeoxyguanosine; oxidative stress; abandoned mine;
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